Biomarkers of Disease: An Evidence-Based Approach

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This new publication takes a critical, evidence-based look at the efficacy of new diagnostic tests which are increasingly being used to evaluate organ damage and dysfunction. The use of biomarkers is growing, with a steady stream of new products being brought out by the pharmaceutical industry. However, in many cases the evidence which supports the use of these new methods as opposed to traditional biochemical tests has not yet been demonstrated, and it is intended that this volume will help clarify the strengths and weaknesses of using these biomarkers across a wide range of applications and in the various organs of the body. This approach will provide an invaluable overview of the diverse applications of biomarkers in medicine.

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Editorial Reviews

Doody's Review Service
Reviewer: Valerie L. Ng, PhD MD(Alameda County Medical Center/Highland Hospital)
Description: This book summarizes the current state of knowledge in the rapidly evolving field of biomarkers and their use in clinical medicine.
Purpose: The purpose is to survey and summarize research findings in the use of biomarkers in health and disease. This book is very timely, given the rapid progress and change in this field.
Audience: This book would appeal to a broad audience — i.e., anyone with an interest in this field such as the lay public, researchers, allied health professionals, and physicians (in training as well as those in practice).
Features: This 48-chapter book covers an amazing array of biomarkers and their usefulness in determining appropriate functioning of many different organ systems. The book starts with a concise, yet well-developed section on the principles of evidence-based medicine (EBM), the industry perspective (and rationale for assay development), relevant statistics, and decision analysis. It is clear that mastery of these topics is essential to understanding their application to the review and analysis of biomarker research studies in subsequent chapters. I particularly enjoyed this first section as it set a great foundation for the remainder of the book. Subsequent sections critically analyze published studies assessing the role of biomarkers in normal function versus disease states of the kidneys, bone, liver, gastrointestinal tract, cardiovascular and neurological system. Finally, there are two sections discussing the role of biomarkers in toxicology and transplantation. Despite the multitude of expert authors, the writing style is remarkably consistent between sections/chapters, with a clear and concise message delivered in each chapter. I also appreciate that the basic premise of laboratory medicine - using clinical utility to drive use of laboratory testing - permeates every chapter. This book appears deceptively small (494 pages, but only about one inch thick), but contains an amazing wealth of information.
Assessment: This is a great book for anyone wanting to get up to speed in this rapidly developing area. I know I will refer to it frequently in the near future as I field requests for biomarker testing, and will keep it readily accessible on my bookshelf!
From the Publisher
"Covers an amazing array of biomarkers and their usefulness in determining appropriate functioning of many different organ systems ... Despite the multitude of expert authors, the writing style is remarkably consistent ... This is a great book for anyone wanting to get up to speed in this rapidly developing area. I know I will refer it frequently in the near future as I field requests for biomarker testing, and will keep it readily accessible on my bookshelf!" Doody's Notes

4 Stars! from Doody
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Product Details

  • ISBN-13: 9780521088602
  • Publisher: Cambridge University Press
  • Publication date: 10/30/2008
  • Edition description: Reprint
  • Pages: 520
  • Product dimensions: 6.60 (w) x 9.50 (h) x 1.20 (d)

Table of Contents

List of contributors
Pt. 1 Assessing and utilizing the diagnostic or prognostic power of biomarkers
1 Evidence-based medicine: evaluation of biomarkers 3
2 Development of biomarkers: the industrial perspective 16
3 Statistical approaches to rational biomarker selection 24
4 Using intelligent systems in clinical decision support 32
Pt. 2 Biomarkers of kidney disease and dysfunction
5 Biomarkers in renal disease 45
6 The genetics of renal disease 56
7 Early markers of nephrotoxicity for environmental and occupational monitoring 66
8 The early detection of renal impairment in diabetes mellitus. The case for microalbuminuria and other biomarkers 76
Pt. 3 Biomarkers of bone disease and dysfunction
9 Bone turnover markers in clinical practice 99
10 Biomarkers of bone formation 115
11 Biochemical markers of bone resorption 122
12 The clinical application of biomarkers in osteoporosis 133
13 Sources of preanalytical variability in the measurement of biochemical markers of bone turnover 140
14 Genetic approaches to the study of complex diseases: osteoporosis 159
Pt. 4 Biomarkers of liver disease and dysfunction
15 Biomarkers of hepatic disease 167
16 The immunogenetics of metabolic liver disease 177
17 Toxicogenetic markers of liver dysfunction 190
18 Prognosis and management of patients with acute liver failure 199
19 Biomarkers in artificial and bioartificial liver support 211
20 Prognostic markers in liver disease 221
21 Apoptosis: biomarkers and the key role of mitochondria 228
22 Liver regeneration: mechanisms and markers 239
23 Determinants of responses to viruses and self in liver disease 244
24 IL-6-type cytokines and signalling in inflammation 256
Pt. 5 Biomarkers of gastrointestinal disease and dysfunction
25 Biomarkers in gastrointestinal disease 265
26 Tumour markers in gastrointestinal disease 272
27 Markers of malabsorption: coeliac disease 281
Pt. 6 Biomarkers in toxicology
28 Genomics and biomarkers in toxicology 291
29 Protein profiling and proteomic databases 299
30 Biomarkers for evaluating the safety of genetically modified foods 313
Pt. 7 Biomarkers of cardiovascular disease and dysfunction
31 The impact of biochemical tests on patient management 325
32 Cardiac natriuretic peptides in risk assessment of patients with acute myocardial infarction or congestive heart failure 334
33 Serum markers of inflammation and cardiovascular risk 345
34 The clinical significance of markers of coagulation in acute coronary syndromes 355
35 Endothelin: what does it tell us about myocardial and endothelial dysfunction? 365
36 Homocysteine: a reversible risk factor for coronary heart disease 374
37 Matrix metalloproteinases and their tissue inhibitors 379
Pt. 8 Biomarkers of neurological disease and dysfunction
38 Biomarkers of neurodegenerative disorders 391
39 Traumatic brain injury: assessment by biochemical serum markers 398
40 An overview of S-100[beta] as a clinically useful biomarker of brain tissue damage 406
Pt. 9 Biomarkers in transplantation
41 Monitoring heart and lung transplant patients 415
42 Monitoring liver transplant recipients 423
43 Chronic allograft damage index as a surrogate marker for chronic allograft rejection 433
44 Advances in pharmacodynamic biomarkers for monitoring the response to immunosuppressive drug therapy 442
45 The use of biomarkers for monitoring the response to immunosuppressive drug therapy 451
46 Post-transplantation bone disease 461
47 Molecular diagnosis of cytomegalovirus disease 467
48 Diagnosis and monitoring of inflammatory events in transplant recipients 474
Index 483
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