Biomaterials Science:: An Introduction to Materials in Medicine

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More About This Textbook

Overview

This book introduces a subject that has profound impact on human health and considerable economic importance. The issues addressed include the biology, medical applications, markets, regulation, and ethical issues involved in biomaterials science. This spectrum of issues reflects the interdisciplinary nature of the field.

Key Features
* Provides a strong, cohesive compilation unlike any other currently on the market
* Covers the entire spectrum of biomaterials and their use in medicine
* Contributions of leaders in the biomaterials field

Audience: Researchers, scientists, and students in the fields of biomaterials, chemistry, physics, engineering, biology, medicine, veterinary medicine, orthopedics, dentistry, including scientists in biotechnology and industry. In addition, attorneys involved in biomaterials litigation, materials scientists, and medical personnel will find much of interest in this book. This area is well-funded by NIH.

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Product Details

  • ISBN-13: 9780125824613
  • Publisher: Elsevier Science & Technology Books
  • Publication date: 5/28/1997
  • Edition description: Older Edition
  • Pages: 484
  • Product dimensions: 8.59 (w) x 11.02 (h) x 0.95 (d)

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Endorsed by the Society for Biomaterials
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Table of Contents

Contributors
Preface
Biomaterials Science: An Interdisciplinary Endeavor 1
Ch. 1 Properties of Materials
1.1 Introduction 11
1.2 Bulk Properties of Materials 11
1.3 Surface Properties of Materials 21
Ch. 2 Classes of Materials Used in Medicine
2.1 Introduction 37
2.2 Metals 37
2.3 Polymers 50
2.4 Hydrogels 60
2.5 Bioresorbable and Bioerodible Materials 64
2.6 Ceramics, Glasses, and Glass-Ceramics 73
2.7 Natural Materials 84
2.8 Composites 94
2.9 Thin Films, Grafts, and Coatings 105
2.10 Fabrics 118
2.11 Biologically Functional Materials 124
Ch. 3 Some Background Concepts
3.1 Introduction 133
3.2 Proteins: Structure, Properties, and Adsorption to Surfaces 133
3.3 Cells: Their Surfaces and Interactions with Materials 141
3.4 Tissues 147
Ch. 4 Host Reactions to Biomaterials and Their Evaluation
4.1 Introduction 165
4.2 Inflammation, Wound Healing, and the Foreign Body Response 165
4.3 Immunology and the Complement System 173
4.4 Systemic Toxicity and Hypersensitivity 188
4.5 Blood Coagulation and Blood-Materials Interactions 193
4.6 Tumorigenesis and Biomaterials 200
4.7 Implant-Associated Infection 205
Ch. 5 Testing Biomaterials
5.1 Introduction 215
5.2 In Vitro Assessment of Tissue Compatibility 215
5.3 In Vivo Assessment of Tissue Compatibility 220
5.4 Testing of Blood-Materials Interactions 228
5.5 Animal Models 238
Ch. 6 Degradation of Materials in the Biological Environment
6.1 Introduction 243
6.2 Chemical and Biochemical Degradation of Polymers 243
6.3 Degradative Effects of the Biological Environment on Metals and Ceramics 260
6.4 Mechanical Breakdown in the Biological Environment 267
6.5 Pathologic Calcification of Biomaterials 272
Ch. 7 Application of Materials in Medicine and Dentistry
7.1 Introduction 283
7.2 Cardiovascular Applications 283
7.3 Nonthrombogenic Treatments and Strategies 297
7.4 Dental Implants 308
7.5 Adhesives and Sealants 319
7.6 Ophthalmologic Applications 328
7.7 Orthopedic Applications 335
7.8 Drug Delivery Systems 346
7.9 Sutures 356
7.10 Burn Dressings 360
7.11 Bioelectrodes 371
7.12 Biomedical Sensors and Biosensors 375
Ch. 8 Artificial Organs
8.1 Introduction 389
8.2 Implantable Pneumatic Artificial Hearts 389
8.3 Extracorporeal Artificial Organs 400
Ch. 9 Implants and Devices
9.1 Introduction 415
9.2 Sterilization of Implants 415
9.3 Cardiovascular Implantation 420
9.4 Dental Implantation 426
9.5 Ophthalmic Implantation 435
9.6 Implant and Device Failure 443
9.7 Correlations of Material Surface Properties with Biological Responses 445
9.8 Implant Retrieval and Evaluation 451
Ch. 10 New Products and Standards
10.1 Introduction 457
10.2 Voluntary Consensus Standards 457
10.3 Product Development and Regulation 461
Ch. 11 Perspectives and Possibilities in Biomaterials Science 465
Appendix Properties of Biological Fluids 469
Index 473
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