Overview

In this exciting 2 volume set, the approach and methodology of bio-inspired synthesis of complex natural products is laid out, backed by abundant practical examples from the authors' own work as well as from the published literature.

Volume 1 describes the biomimetic synthesis of alkaloids.

Volume 2 covers terpenes, polyketides, and ...

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Biomimetic Organic Synthesis

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Overview

In this exciting 2 volume set, the approach and methodology of bio-inspired synthesis of complex natural products is laid out, backed by abundant practical examples from the authors' own work as well as from the published literature.

Volume 1 describes the biomimetic synthesis of alkaloids.

Volume 2 covers terpenes, polyketides, and polyphenols.

A discussion of the current challenges and frontiers in biomimetic synthesis concludes this comprehensive handbook.

Key features:

  • Biomimetic Strategies have become an every-day tool not only for chemists but also for biologists. The synthetic applications are overwhelming, making this comprehensive 2 volume work a must-have for everyone working in the field.
  • Unifying both synthetic and biosynthetic aspects, this book covers everything from organocatalysis and natural product synthesis to synthetic biology and even green chemistry.
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Product Details

  • ISBN-13: 9783527634767
  • Publisher: Wiley, John & Sons, Incorporated
  • Publication date: 5/9/2011
  • Sold by: Barnes & Noble
  • Format: eBook
  • Edition number: 1
  • Pages: 900
  • File size: 73 MB
  • Note: This product may take a few minutes to download.

Meet the Author

Erwan Poupon obtained his PhD in Pharmacy under the supervision of Dr. Nicole Kunesch and Prof. Henri-Philippe Husson in 2000. He was subsequently a post-doctoral fellow at the University of California at San Diego - La Jolla with Prof. Emmanuel Theodorakis. He then joined the faculty at the Paris-Sud School of Pharmacy where he is now professor of pharmacognosy. His fields of interest relate to the chemistry of natural products, including biomimetic synthesis and chemical biology.

Bastien Nay followed pharmacy studies before completing his PhD under the guidance of Prof. Joseph Vercauteren at the School of Pharmacy of Bordeaux, France. Having obtained his academic degree in 2000, he joined Prof. Stephen Clark's group as a research associate in the Unviersity of Nottingham, UK, and the Dr. Poupat team at the Institut de Chimie des Substances Naturelles (CNRS), Gif-sur-Yvette, France. In 2003 he was appointed research scientist at the CNRS, working at the National Museum of Natural History in Paris, where he is now responsible for the natural product chemistry team. His research interests concern the thotal synthesis of natural products and associated methodologies.

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Table of Contents

VOLUME 1
PART I BIOMIMETIC TOTAL SYNTHESIS OF ALKALOIDS Biomimetic Synthesis of Ornithine/Arginine and Lysine-Derived Alkaloids: Selected Examples Biomimetic Synthesis of Alkaloids Derived from Tyrosine: The Case of FR-901483 and TAN-1251 Compounds Biomimetic Synthesis of Alkaloids Derived from Tryptophan: Indolemonoterpene Alkaloids Biomimetic Synthesis of Alkaloids Derived from Tryptophan: Dioxopiperazine Alkaloids Biomimetic Synthesis of Alkaloids with a Modified Indole Nucleus Biomimetic Synthesis of Manzamine Alkaloids Biomimetic Synthesis of Marine Pyrrole-2-Aminoimidazole and Guanidinium Alkaloids Biomimetic Syntheses of Alkaloids with a Non-Amino Acid Origin Biomimetic Synthesis of Azole- and Aryl-Peptide Alkaloids Biomimetic Synthesis of Indole-Oxidized and Complex Peptide Alkaloids VOLUME 2
PART II BIOMIMETIC SYNTHESIS OF TERPENOIDS AND POLYPRENYLATED NATURAL COMPOUNDS Biomimetic Rearrangements of Complex Terpenoids Polyprenylated Phloroglucinols and Xanthones PART III BIOMIMETIC SYNTHESIS OF POLYKETIDES Polyketide Assembly Mimics and Biomimetic Access to Aromatic Rings Biomimetic Synthesis of Non-Aromatic Polycyclic Polyketides Biomimetic Synthesis of Polyether Natural Products via Polyepoxide Opening Biomimetic Electrocyclization Reactions toward Polyketide-Derived Natural Products PART IV BIOMIMETIC SYNTHESIS OF POLYPHENOLS Biomimetic Synthesis and Related Reactions of Ellagitannins Biomimetic Synthesis of Lignans Synthetic Approaches to the Resveratrol-Based Family of Oligomeric Natural Products Sequential Reactions Initiated by Oxidative Dearomatization. Biomimicry or Artifact?
PART V FRONTIERS IN BIOMIMETIC CHEMISTRY: FROM BIOLOGICAL TO BIO-INSPIRED PROCESSES The Diels'Alderase Never Ending Story Bio-Inspired Transfer Hydrogenations Life's Single Chirality: Origin of Symmetry Breaking in Biomolecules PART VI CONCLUSION: FROM NATURAL FACTS TO CHEMICAL FICTIONS Artifacts and Natural Substances Formed Spontaneously

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