BioNMR in Drug Research / Edition 1

Hardcover (Print)
Buy New
Buy New from BN.com
$225.71
Used and New from Other Sellers
Used and New from Other Sellers
from $46.88
Usually ships in 1-2 business days
(Save 80%)
Other sellers (Hardcover)
  • All (8) from $46.88   
  • New (5) from $194.15   
  • Used (3) from $46.88   

Overview

The vast progress made in the investigation of biomolecules using NMR has only recently been rewarded with the Nobel Prize for Kurt Wüthrich. Edited by a former coworker of Wüthrich, this book presents the theoretical background on NMR of biomolecules, plus the use of NMR techniques in determining the structures of proteins and nucleic acids.
BioNMR spectroscopy offers a universal tool for examining the binding of an active substance to its target protein. Its use thereby benefits the rational development of drugs. This interaction can now be investigated in a hitherto unparalleled precision and displayed in 3D - an important prerequisite for the targeted development of new active substances. The latest methods for characterizing substance-receptor complexes are demonstrated backed by many case studies from pharmaceutical research. Thus it comes as no surprise that a large number of the authors are working for leading pharmaceutical companies.
With its successful mixture of basic information and application strategies, coupled with many real-life examples, this is an invaluable guide for both NMR spectroscopists and pharmaceutical researchers.
Read More Show Less

Editorial Reviews

From the Publisher
"The editor has managed to recruit a team of well-recognized experts as authors for this book, thereby ensuring a high standard of reliable and objective reporting. The book is not only of interest to specialists in pharmaceutical research and development, but will certainly also be a valuable resource for everyone concerned with the latest methods of NMR spectroscopy and their application to biomolecules"
(Angewandte Chemie Int. Ed.)

"The book presents a good overview of state-of-the-art NMR techniques in drug discovery. [...] It is suggested reading for people involved in pharmaceutical research as well as academic researchers with an interest in drug discovery."
(ChemBioChem)

"...certainly a valuable resource for everyone concerned with the latest methods of NMR spectroscopy and their applications..." Angewandte Chemie Int. Edition

Read More Show Less

Product Details

Meet the Author

  • The tragic events of September 11 had an immediate impact on travel. Yet each week more Americans are returning to the roads and skies. With 305 titles, Frommer's covers the world, so no matter where travelers decide to go, or how they decide to get there, we'll have the guide for them.
  • In economically challenged times, Frommer's will outsell Fodor's because we recommend more moderately priced hotels and restaurants, and unlike Fodor's, we give exact prices.
Read More Show Less

Table of Contents

BASIC TECHNIQUES
Modern Methods for Expression of Proteins in Isotopically Enriched Form
Structure Calculation Using Automated Techniques
Achieving Better Sensitivity, Less Noise and Less Artifacts in NMR Spectra

NMR OF BIOMOLECULES
NMR Strategies for Protein Assignment
NMR of Membrane-Associated Peptides and Proteins
NMR of Nucleic Acids

MODERN SPECTROSCOPIC TECHNIQUES
Methods for the Measurement of Angle Restraints from Scalar and Dipolar Couplings as well as from Cross Correlated Relaxation: Application to Biomolecules
Orientational Restraints
Scalar Coupling Across Hydrogen Bonds
TROSY:Transverse Relaxation-Optimized Spectroscopy
MAS Solid-State NMR of Isotopically Enriched Biological Samples
Determination of Protein Dynamics Using 15N Relaxation Measurements

TOOLS FOR INVESTIGATION OF DRUG-RECEPTOR COMPLEXES AND FOR LIGAND SCREENING
The Determination of Equilibrium Dissociation Constants of Protein-Ligand Complexes by NMR
Experiments in NMR-based Screening
The Use of Spin-Labels in NMR-supported Lead Finding and Optimization
NMR of Weakly Binding Ligands
Isotope Filter and Editing Techniques

STRATEGIES FOR DRUG DEVELOPMENT USING NMR
Strategies for NMR Screening and Library Design
Strategies for Hit Finding Using NMR
Strategies for Drug Discovery Using NMR
NMR-based Drug Design: Approaches for Very Large Proteins

Read More Show Less

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star

(0)

4 Star

(0)

3 Star

(0)

2 Star

(0)

1 Star

(0)

Your Rating:

Your Name: Create a Pen Name or

Barnes & Noble.com Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & Noble.com that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & Noble.com does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at BN.com or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation

Reminder:

  • - By submitting a review, you grant to Barnes & Noble.com and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Noble.com Terms of Use.
  • - Barnes & Noble.com reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & Noble.com also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on BN.com. It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

 
Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)