Biopharmaceutical Drug Design and Development / Edition 2

Biopharmaceutical Drug Design and Development / Edition 2

by Susanna Wu-Pong
     
 

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ISBN-10: 1588297160

ISBN-13: 9781588297167

Pub. Date: 06/06/2008

Publisher: Springer-Verlag New York, LLC

*Comprehensive examination of the newest biopharmaceutical drugs *Detailed investigation of revolutionary inventions and techniques, including cloning and microarray technology *Review of the Human Genome Project Biopharmaceutical Drug Design and Development, Second Edition, updates the widely successful first edition, published in 1999. This new, expanded edition

Overview

*Comprehensive examination of the newest biopharmaceutical drugs *Detailed investigation of revolutionary inventions and techniques, including cloning and microarray technology *Review of the Human Genome Project Biopharmaceutical Drug Design and Development, Second Edition, updates the widely successful first edition, published in 1999. This new, expanded edition investigates the dozens of new biopharmaceutical drugs that have become available since the publication of the first edition. Among the drugs discussed are ones in the categories of monoclonal antibodies for in-vivo use, cytokines, growth factors, enzymes, immunomodulators, thrombolytics, and immonotherapies including vaccines. Additionally, the volume examines new and emerging technologies, such as bioinformatics, DNA microarrays, transgenics, therapeutic gene delivery, stem cells, nucleic acid-based therapeutics, and macromolecular drug delivery. Authors also study pharmacogenetics in the clinic and changes in biologic drug approval at the FDA. Biopharmaceutical Drug Design and Development, Second Edition, is a worthy sequel in the discussion on the dynamic, exciting field of biotechnology. Written for: Graduate students and post-docs, pharmacologists, molecular biologists, biochemists, biologists

Product Details

ISBN-13:
9781588297167
Publisher:
Springer-Verlag New York, LLC
Publication date:
06/06/2008
Edition description:
2nd ed. 2008
Pages:
375
Product dimensions:
5.98(w) x 9.02(h) x 0.04(d)

Table of Contents


Preface     v
Contributors     ix
Biotechnology: 2008 and Beyond   Susanna Wu-Pong     1
The Human Genome Project and Drug Development   Susanna Wu-Pong     15
The Use of Bioinformatics and Chemogenomics in Drug Discovery   Susanna Wu-Pong   Rita Shiang     31
DNA Microarrays in Drug Discovery and Development   Neelam Azad   Anand Krishnan V. Iyer   Yon Rojanasakul     47
Microarray Technology Using Proteins, Cells, and Tissues   Michael Samuels     67
Pharmacogenetic Issues in Biopharmaceutical Drug Development   Robert L. Haining     99
Development and Applications of Transgenics in Biotechnology and Medicine   Wagner Dos Santos   Helen L. Fillmore     121
Viral, Nonviral, and Physical Methods for Gene Delivery   Jingjiao Guan   Xiaogang Pan   L. James Lee   Robert J. Lee     141
Stem Cell Technology and Drug Development   Helen Fillmore   Susanna Wu-Pong     175
Small Nucleic Acid-Based Drug: Successes and Pitfalls   A. Yin Zhang   Susanna Wu-Pong     193
Therapeutic Strategies Targeting the Innate Antiviral Immune Response   Robert C. Tam   ZhiHong   Miriana Moran   Andrei Varnavski   Sung-Kwon Kim     223
Pharmacogenetics in the Clinic   Kai I. Cheang     253
Molecular Modeling: Considerations for the Design of Pharmaceuticals and Biopharmaceuticals   Philip D. Mosier   Glen E. Kellogg     267
Macromolecular Drug Delivery   Neelam Azad   Yon Rojanasakul     293
Changes in Biologic Drug Approval at FDA   Richard E. Lowenthal   Robert G. Bell     325
Follow-On Protein Products: The Age of Biogenerics?   Robert G. Bell     345
Index     367

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