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The book contains black-and-white illustrations.
This is a unique comprehensive survey and review of the status of the rapidly increasing array of biopharmaceuticals derived from the molecular biology approaches now so widely available. Designed as an introduction for the novice, or even the professional already acquainted with molecular therapeutics, who wishes to become familiar with both the basics and range of biopharmaceutical initiatives now underway, this informative book illuminates and explains macromolecular and biological drug design, as well as the development, delivery, clinical trials, and government regulation of the new therapeutics. Its eminently practical approach takes the reader from basic biotechnology, through drug conception and design, to state-of-the-art clinical application of both investigational and currently approved biologicals. This book will help medicinal chemists, molecular modelers, pharmacologists, pharmaceutical scientists, and clinical scientists involved in pharmaceutical biotechnology and how best to develop the new therapeutic agents that lie so close ahead.
|Ch. 1||An Overview of Biotechnology||1|
|Ch. 2||Basic Elements of Molecular Biology||21|
|Ch. 3||Tools for Molecular Analysis||37|
|Ch. 4||Treatment Options||51|
|Ch. 5||Viral Vectors for Gene Therapy||69|
|Ch. 6||Nonviral Gene Delivery||107|
|Ch. 7||Oligonucleotides and Ribozymes||143|
|Ch. 8||Design and Engineering of Proteins as Therapeutic Agents||187|
|Ch. 9||Challenges and Issues in the Development of Formulations of Protein Pharmaceuticals||205|
|Ch. 10||Protein Drug Delivery||239|
|Ch. 11||Protein Drug Manufacturing||275|
|Ch. 14||Product Development and New Drug Approval||375|
|Ch. 15||Therapeutic Use of Recombinant Proteins||393|