Biopharmaceutical Drug Design and Development / Edition 2

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Overview

Biopharmaceutical Drug Design and Development, Second Edition, updates the widely successful first edition, published in 1999. This new, expanded edition investigates the dozens of new biopharmaceutical drugs that have become available since the publication of the first edition. Among the drugs discussed are ones in the categories of monoclonal antibodies for in-vivo use, cytokines, growth factors, enzymes, immunomodulators, thrombolytics, and immunotherapies, including vaccines. Additionally, the volume examines new and emerging technologies, such as bioinformatics, DNA microarrays, transgenics, therapeutic gene delivery, stem cells, nucleic acid-based therapeutics, and macromolecular drug delivery. Authors also study pharmacogenetics in the clinic and changes in biologic drug approval at the FDA. Biopharmaceutical Drug Design and Development, Second Edition, is a worthy sequel in the discussion on the dynamic, exciting field of biotechnology.

The book contains black-and-white illustrations.

This is a unique comprehensive survey and review of the status of the rapidly increasing array of biopharmaceuticals derived from the molecular biology approaches now so widely available. Designed as an introduction for the novice, or even the professional already acquainted with molecular therapeutics, who wishes to become familiar with both the basics and range of biopharmaceutical initiatives now underway, this informative book illuminates and explains macromolecular and biological drug design, as well as the development, delivery, clinical trials, and government regulation of the new therapeutics. Its eminently practical approach takes the reader from basic biotechnology, through drug conception and design, to state-of-the-art clinical application of both investigational and currently approved biologicals. This book will help medicinal chemists, molecular modelers, pharmacologists, pharmaceutical scientists, and clinical scientists involved in pharmaceutical biotechnology and how best to develop the new therapeutic agents that lie so close ahead.

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Editorial Reviews

Booknews
This practical introduction takes readers from basic biotechnology through drug conception and design and clinical application. Following an overview of the biotechnology industry, basic elements of molecular biology, and tools for molecular analysis, chapters cover: treatment options; viral vectors for gene therapy; nonviral gene delivery; oligonucleotides and ribozymes; design and engineering of proteins as therapeutic agents; challenges and issues in the development of formulations of protein pharmaceuticals; protein drug delivery and manufacturing; antibodies; immunotherapy; product development and new drug approval; and therapeutic use of recombinant proteins. Annotation c. Book News, Inc., Portland, OR (booknews.com)
From the Publisher
From the reviews of the second edition:

"The book comprises 16 chapters written by 24 authors from academic and industrial laboratories in the U.S. The book is suitable for a wide audience of industrial and academic pharmaceutical scientists interested in a broad introduction to biopharmaceutical technology within the context of drug design and development. … Overall, the book is well written with an excellent nine-page index. The chapters are generally well illustrated. … it would be a valuable addition to industrial and academic libraries." (Aliasger K. Salem, Journal of Medicinal Chemistry, Vol. 51 (19), 2008)

"This book is an update of the first edition of Biopharmaceutical Drug Development … . this book is dedicated to quite detailed discussion of the impact the various ‘omic’ technologies have had on drug discovery and design. … Overall, this is quite a useful reference book for toxicologists working in the biopharmaceutical sector, particularly if they are still getting to grips with the various ‘omics’ technologies and areas such stem cell therapy and gene silencing." (Peter Ryle, British Toxicological Society Newsletter, June-August, 2009)

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Product Details

  • ISBN-13: 9781588297167
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 6/6/2008
  • Edition description: 2nd ed. 2008
  • Edition number: 2
  • Pages: 375
  • Product dimensions: 6.32 (w) x 9.08 (h) x 1.05 (d)

Table of Contents

Foreword
Preface
Contributors
Ch. 1 An Overview of Biotechnology 1
Ch. 2 Basic Elements of Molecular Biology 21
Ch. 3 Tools for Molecular Analysis 37
Ch. 4 Treatment Options 51
Ch. 5 Viral Vectors for Gene Therapy 69
Ch. 6 Nonviral Gene Delivery 107
Ch. 7 Oligonucleotides and Ribozymes 143
Ch. 8 Design and Engineering of Proteins as Therapeutic Agents 187
Ch. 9 Challenges and Issues in the Development of Formulations of Protein Pharmaceuticals 205
Ch. 10 Protein Drug Delivery 239
Ch. 11 Protein Drug Manufacturing 275
Ch. 12 Antibodies 329
Ch. 13 Immunotherapy 349
Ch. 14 Product Development and New Drug Approval 375
Ch. 15 Therapeutic Use of Recombinant Proteins 393
Index 429
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