Bioprocess Engineering Principles / Edition 2

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Overview

The emergence and refinement of techniques in molecular biology has changed our perceptions of medicine, agriculture, and environmental management. Scientific breakthroughs in gene expression, protein engineering, and cell fusion are being translated by a strengthening biotechnology industry into revolutionary new products and services. Many a student has been enticed by the promise of biotechnology and the excitement of being near the cutting edge of scientific advancement. However, graduates trained in molecular biology and cell manipulation soon realize that these techniques are only part of the picture. Reaping the full benefits of biotechnology requires manufacturing capability involving the large-scale processing of biological material. Increasingly, biotechnologists are being employed by companies to work in cooperation with chemical engineers to achieve pragmatic commercial goals. For many years, aspects of biochemistry and molecular genetics have been included in chemical engineering curricula, yet there has been little attempt until recently to teach aspects of engineering applicable to process design to biotechnologists.
This textbook is the first to present the principles of bioprocess engineering in a way that is accessible to biological scientists. Other texts on bioprocess engineering currently available assume that the reader already has engineering training. On the other hand, chemical engineering textbooks do not consider examples from bioprocessing, and are written almost exclusively with the petroleum and chemical industries in mind. This publication explains process analysis from an engineering point of view, but refers exclusively to the treatment of biological systems. Over 170 problems and worked examples encompass a wide range of applications, including recombinant plant and animal cell cultures, immobilized catalysts, as well as traditional fermentation systems.

Key Features
* First book to present the principles of bioprocess engineering in a way that is accessible to biological scientists
* Explains process analysis from an engineering point of view, but uses worked exam

Audience: Senior undergraduate students in applied biology taking final year options in bioprocessing/biotechnology and graduate students in biological sciences taking masters courses, or beginning research in engineering departments. This book should also be useful to undergraduates taking new, emerging courses bridging the gap between biology and engineering, such as BS/BSc in process biotechnology, biotechnology, and bioprocessing. In addition, undergraduates/graduates in chemical engineering taking courses in bioengineering will benefit from this text. Finally, industrial practitioners working in biotechnology, pharmaceutical companies, food industries, and those trained in molecular biology and cell manipulation, who need to acquire knowledge on the principles of large scale processing of biological material.

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Editorial Reviews

From the Publisher
From the Prepublication Reviews:
"In general the text is very well written, well organized and is of high quality in all respects.... The emphasis on physical explanations that accompany the equations is very helpful.... The coverage is very complete and comprehensive."
-DAVID DIBIASIO, WORCESTER POLYTECHNIC INSTITUTE, MASSACHUSETTS, USA
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Product Details

  • ISBN-13: 9780122208515
  • Publisher: Elsevier Science
  • Publication date: 6/13/2012
  • Edition description: New Edition
  • Edition number: 2
  • Pages: 928
  • Sales rank: 929,468
  • Product dimensions: 7.70 (w) x 9.30 (h) x 2.00 (d)

Table of Contents

Preface
Ch. 1 Bioprocess Development: An Interdisciplinary Challenge 3
Ch. 2 Introduction to Engineering Calculations 9
Ch. 3 Presentation and Analysis of Data 27
Ch. 4 Material Balances 51
Ch. 5 Energy Balances 86
Ch. 6 Unsteady-State Material and Energy Balances 110
Ch. 7 Fluid Flow and Mixing 129
Ch. 8 Heat Transfer 164
Ch. 9 Mass Transfer 190
Ch. 10 Unit Operations 218
Ch. 11 Homogeneous Reactions 257
Ch. 12 Heterogeneous Reactions 297
Ch. 13 Reactor Engineering 333
Appendices 393
Appendix A Conversion Factors 395
Appendix B Physical and Chemical Property Data 398
Appendix C Steam Tables 408
Appendix D Mathematical Rules 413
Appendix E List of Symbols 417
Index 417
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