Bioseparations Science and Engineering / Edition 1

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Overview

Designed for undergraduates, graduate students, and industry practitioners, Bioseparations Science and Engineering fills a critical need in the field. Current, comprehensive, and concise, it covers bioseparations unit operations in greater depth than other texts on this topic. In each of the chapters, the authors use a consistent method of explaining unit operations, starting with a qualitative description noting the significance and general application of the unit operation. They then illustrate the scientific foundation of the operation, develop the required mathematical theory, and finally, describe the applications of the theory in engineering practice, with an emphasis on design and scaleup. Unique to this text is a chapter dedicated to bioseparations process design and economics. In which a process simulator, SuperPro Designer, is used to analyze and evaluate the production of three important biological products. Other unique features include basic information about bioproducts and engineering analysis and a chapter with bioseparations laboratory exercises. Bioseparations Science and Engineering is ideal for students and professionals alike.
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Editorial Reviews

From the Publisher

"I'm glad I found this book! Unlike many other books of similar titles, this is one that I can really understand. Not too heavy dosage of biological terms. Provides good linkage between the biological science and engineering applications. Good for students who have chamical engineering backgrounds and want to venture into bioseparations. The additional chapter on plant design and economics is also very beneficial."
--reader review from amazon.com

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Product Details

  • ISBN-13: 9780195123401
  • Publisher: Oxford University Press
  • Publication date: 10/31/2002
  • Series: Topics in Chemical Engineering Series
  • Edition description: New Edition
  • Edition number: 1
  • Pages: 432
  • Sales rank: 790,464
  • Product dimensions: 9.40 (w) x 7.30 (h) x 1.10 (d)

Meet the Author

Roger G. Harrison is Professor in the College of Engineering at the University of Oklahoma.
Scott R. Rudge is Technical Leader at RMC Pharmaceutical Solutions, Inc.
Paul W. Todd is Chief Scientist at Techshot, Inc.
Demetri P. Petrides is President of Intelligen, Inc.

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Table of Contents

Preface
Ch. 1 Introduction to Bioproducts and Bioseparations 1
Broad Classification of Bioproducts 3
Small Biomolecules 4
Macromolecules: Proteins 14
Macromolecules: Nucleic Acids and Oligonucleotides 27
Macromolecules: Polysaccharides 29
Particulate Products 31
Introduction to Bioseparations: Engineering Analysis 31
The Route to Market 37
Ch. 2 Analytical Methods 43
Specifications 44
Assay Attributes 45
Analysis of Biological Activity 49
Analysis of Purity 52
Microbiology Assays 75
Ch. 3 Cell Lysis and Flocculation 83
Some Elements of Cell Structure 84
Cell Lysis 86
Flocculation 92
Ch. 4 Filtration 104
Filtration Principles 105
Filter Media and Equipment 117
Membrane Fouling 124
Scaleup and Design of Filtration Systems 126
Ch. 5 Sedimentation 142
Sedimentation Principles 143
Methods and Coefficients 146
Production Centrifuges: Comparison and Engineering Analysis 149
Ultracentrifugation 156
Flocculation and Sedimentation 157
Sedimentation at Low Accelerations 158
Centrifugal Elutriation 162
Ch. 6 Extraction 169
Extraction Principles 170
Scaleup and Design of Extractors 181
Ch. 7 Liquid Chromatography and Adsorption 191
Adsorption Equilibrium 193
Adsorption Column Dynamics 195
Chromatography Column Dynamics 203
Adsorbent Types 215
Particle Size and Pressure Drop in Fixed Beds 220
Equipment 221
Scaleup 224
Ch. 8 Precipitation 243
Protein Solubility 244
Precipitate Formation Phenomena 249
Particle Size Distribution in a Continuous Flow Stirred Tank Reactor 258
Methods of Precipitation 261
Design of Precipitation Systems 264
Ch. 9 Crystallization 272
Crystallization Principles 273
Batch Crystallizers 277
Process Crystallization of Proteins 281
Crystallizer Scaleup and Design 282
Ch. 10 Drying 290
Drying Principles 291
Dryer Description and Operation 303
Scaleup and Design of Drying Systems 308
Ch. 11 Bioprocess Design 319
Delinitions and Background 320
Synthesis of Bioseparation Processes 322
Process Analysis 329
Process Economics 334
Illustrative Examples 343
Ch. 12 Laboratory Exercises in Bioseparations 373
Flocculant Screening 373
Crossflow Filtration 376
Centrifugation of Flocculated and Unflocculated Particulates 377
Aqueous Two-Phase Extraction 381
Chromatography Scaleup 386
App.: Table of Units and Constants 392
Index 395
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