Biotargets of Cancer in Current Clinical Practice

Overview

Biotargets of Cancer in Current Clinical Practice presents an updated and reasoned review of the current status of knowledge concerning the major cancer types with a special focus on the current biomarkers, genes involved and the potential future targets of innovative therapies. The volume includes for each major cancer type, a comprehensive although concise discussion of epidemiology, affirmed and innovative biomarkers for diagnosis, and descriptions of the relevant genes for prognosis and (individualized) ...

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Hardcover (2012)
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Overview

Biotargets of Cancer in Current Clinical Practice presents an updated and reasoned review of the current status of knowledge concerning the major cancer types with a special focus on the current biomarkers, genes involved and the potential future targets of innovative therapies. The volume includes for each major cancer type, a comprehensive although concise discussion of epidemiology, affirmed and innovative biomarkers for diagnosis, and descriptions of the relevant genes for prognosis and (individualized) therapy through biotarget-specific new molecular treatments, with the latest information on the validation status of each novel biomarker. Individual chapters are dedicated to the major cancer types, plus a special chapter on metastasis. The present debate on patentability of genetic information applied to diagnostics and therapeutics of cancer is also discussed.

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Editorial Reviews

From The Critics
Reviewer: Natalie M Webster, MD(University of Kansas Medical Center)
Description: In this book on clinically significant biotargets in cancer research, every organ system is thoroughly represented with adequate overviews and precise details of the biotargets. It presents pertinent clinicopathologic background for each cancer type, including an introduction, incidence and mortality, and clinical presentation, in addition to the well-synthesized biomolecular research that is occurring in the realm of biotargets and targeted therapies.
Purpose: "This purpose is to provide an update on biotargets of cancer to those involved in the care of oncology patients, ranging from medical students to oncologists and pathologists. This book includes, for each organ system and cancer type, a thorough yet concise discussion of epidemiology, biomarkers for diagnosis, description of genes relevant to prognosis, and therapy through biotarget-specific new molecules. These are important objectives, as personalized medicine comes to the forefront of patient care, and this book consistently meets them. "
Audience: According to the editor, the book is intended specifically for clinicians in the field, including medical students, residents, pathologists, and oncologists.
Features: "This book discusses each major cancer type and includes a comprehensive yet concise discussion of epidemiological factors, biomarkers for diagnosis, descriptions of relevant genes used to determine prognosis, and potential for individualized therapies. The best feature of this book is the way it focuses on each major cancer type and discusses all of these aspects in a thorough yet concise manner. It is also helpful to have a concise discussion regarding the biotargets of each individual tumor and how that is translated into clinical practice, including individualized therapies. The book lacks color art, but the diagrams and illustrations are well done and easy to read. "
Assessment: This is a well-written book that attempts to provide a wide spectrum of current scientific information about the clinical management of oncologic patients based on molecular aspects. It would be easy to get carried away and create a book that is exhaustive and difficult to read, as many authors do. However, this book achieves its objectives while remaining easy to read.
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Product Details

  • ISBN-13: 9781617796142
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 4/5/2012
  • Series: Current Clinical Pathology Series
  • Edition description: 2012
  • Edition number: 1
  • Pages: 579
  • Product dimensions: 7.10 (w) x 10.10 (h) x 1.40 (d)

Meet the Author

Mauro Bologna, MD University of L’Aquila, L’Aquila, Italy

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Table of Contents

Ch. 1- Central Nervous System Tumors
Paolo Aloisi
Francesco Martella
Davide Cerone
Giampiero Porzio

Ch. 2- Head and Neck Tumors
Keith D. Hunter
Robert Bolt Ch. 3- Thyroid Cancer
Laura D. Locati
Angela Greco
Maria Grazia Borrello
Maria Luisa Carcangiu
Paolo Bossi
Roberta Granata
Lisa Licitra Ch. 4- Targeted Therapies for Non-Small Cell Lung Cancer
Giulio Metro
Lucio Crinò
Ch. 5- Non-Hodgkin Lymphomas
Roberta Zappasodi
Massimo Di Nicola Ch. 6- Leukemias
Lia Ginaldi
Massimo De Martinis Ch. 7- Breast Cancer
Nadia Rucci
Luca Ventura
Anna Teti Ch. 8- Esophago-Gastric Cancer
Alex M. Reece-Smith
Simon L. Parsons
Sue A. Watson Ch. 9- Colorectal Cancer
David Church
Rachel Midgley
David Kerr Ch. 10- Hepaellular Carcinoma
Yasunori Minami
Masatoshi Kudo Ch. 11- Biomarkers for Prognosis and Molecularly Targeted Therapy in Renal Cell Carcinoma
Laura S. Schmidt Ch. 12- Bladder Cancer
Andrea Tubaro
Daniele Santini
Cosimo De Nunzio
Alice Zoccoli
Michele Iuliano Ch. 13- Biomarkers in Prostate cancer
Mauro Bologna
Carlo Vicentini Ch. 14- Ovarian Cancer
JessicaWangui Oribabor
Allison Ambrosio
Cesar M. Castro
Michael J. Birrer Ch. 15- Uterine Cancer: The Influence of Genetics and Environment on Cell Cycling Pathways in Cancer
Annekathryn Goodman
Leslie S. Bradford
Leslie A. Garrett

Ch. 16- Biotargets in Sarcomas: The Past, Present and a Look into the Future
Vivek Subbiah
Razelle Kurzrock Ch. 17- Melanoma and other skin cancers
Kim H.T. Paraiso
Jobin K. John
Keiran S.M. Smalley Ch. 18- Molecular pathology of cancer metastasis: suggestions for future therapy
Adriano Angelucci
Edoardo Alesse Ch. 19- Current and future developments in cancer therapy research: miRNAs as new promising targets or tools
Marilena V. Iorio
Patrizia Casalini
Claudia Piovan
Luca Braccioli
Elda Tagliabue

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