Biotics and the Gut-Brain Axis in Neurological Disorders

by Neeraj Mishra (Editor), Sumel Ashique (Editor), Mithun Bhowmick (Editor)

Overview

This book reviews the pivotal role of prebiotics, probiotics, and postbiotics in modulating the gut-brain axis, offering insights into their potential therapeutic applications and impact on neurological health. The initial chapters provide a foundational overview of prebiotics and introduce readers to the concept of the gut-brain axis. It discusses bi-directional communication within the gut-brain axis and the impacts of gut dysbiosis on neurological health. Further chapters investigate the relationship between the gut-brain axis and autoimmune diseases and the role of probiotics in major neurodegenerative diseases such as Alzheimer's and Parkinson's, ALS and Huntington's disease, and conditions like MS, epilepsy, and seizures. It also examines the influence of prebiotics on mental health disorders such as anxiety and depression, and their impact on ischemic stroke via the gut-brain axis. The book further covers the role of probiotics in ROS and inflammation-mediated neurodegenerative diseases, and the correlation between gut microbiota, malnutrition, and neurological disorders. The book explores the signaling pathways within the gut-brain axis and their relationships with neurological disorders, the application of prebiotics as functional foods, and the therapeutic potential of postbiotics and psychobiotics. This book is intended for scientists and researchers in the fields of microbiology, neuroscience, and gastroenterology. 

Key Features

• Provides a thorough understanding of prebiotics, probiotics, and postbiotics, and their roles in the gut-brain axis.
• Explores bi-directional communication within the gut-brain axis and its impact on neurological health.
• Examines the relationship between the gut microbiota and various neurological disorders.
• Discusses the influence of prebiotics and probiotics on mental health disorders such as anxiety and depression.
• Investigates the connection between the gut-brain axis and autoimmune diseases.
• Covers advanced tools and bioinformatics approaches for studying gut microbiota and neurodegeneration.

Product Details

ISBN-13:	9781032882390
Publisher:	CRC Press
Publication date:	11/24/2025
Pages:	408
Product dimensions:	8.25(w) x 11.00(h) x (d)

About the Author

Neeraj Mishra has been serving as Professor and Head of the Department at the Amity Institute of Pharmacy, Amity University, Gwalior, since July 2019. With approximately twenty years of experience in teaching and research, Dr. Mishra has made significant contributions to the field. He has over 125 publications in both international and national journals, focusing on novel drug delivery systems, oral delivery of synbiotics, localized drug delivery, and targeted and controlled delivery of nanocarriers and microparticles for treating breast and colon cancer, as well as neurodegenerative disorders. He has authored more than 15 books and 25 book chapters and holds 3 international patents and 3 Indian patents. His achievements have been recognized with several awards, including the “Distinguished Professor Award” from DST-NSTMIS, SPAICS, Indore, in 2019, and the “Outstanding Scientist Award” at the 6th International Scientist Awards on Engineering, Science, and Medicine in 2020. He also received the “Distinguished Professor Award” from the Indian Pharmaceutical Association, MP State Branch, in 2021, and the “Best Academician Award” at the Indian Pharmacy Graduate Association, M.P. State International Conference in 2023.

 Sumel Ashique is an assistant professor at the Department of Pharmaceutical Technology, Bharat Technology, Uluberia-711316, West Bengal, India. With 5 years of teaching experience, he has made notable contributions to his field. He has published more than 100 papers in reputable international and national journals. His expertise includes drug delivery, nanotechnology, and targeted treatment strategies. He also serves as a reviewer for several prestigious international journals. He holds 5 granted patents from IP Australia, India and Canada and has contributed 20 book chapters, and has edited 18 books.

 Mithun Bhowmick is currently serving as Professor and Principal at the Bengal College of Pharmaceutical Sciences & Research in Durgapur, West Bengal. He has received numerous prestigious awards throughout his career. Dr. Bhowmick has actively participated in and presented research papers at various international and national conferences. He has published more than 50 research and review papers in esteemed national and international journals. His accomplishments include several patents from Australia, Germany, and India, as well as design patents and copyrights. Dr. Bhowmick is a reviewer for numerous pharmaceutical journals and is a lifetime member of several professional organizations, including the Association of Pharmaceutical Teachers of India (APTI), the Indian Pharmacy Graduate's Association (IPGA), and the Institute of Scholars (InSc.). He is also a registered fellow member of the Centre for Education Growth and Research (CEGR) in New Delhi.

Table of Contents

Prebiotics: General Overview, Characteristics, and Application in Health Benefits. 2. Introduction to the Gut-Brain Axis. 3. Introduction and overview of prebiotics, probiotics, and postbiotics. 4. Bi-directional Communication in the Gut-Brain Axis. 5. Gut-Dysbiosis and Its Impact on Neurological Health. 6. Connection between Gut Microbiota with Neurodegenerative Diseases. 7. Gut-Microbiota in Mental Health Disorders. 8. Gut Brain Axis and Autoimmune diseases: Correlation between both. 9. Signaling events from the Gut: Regulate brain function and its link to autoimmune disorders. 10. Role of Probiotics in Alzheimer's disease and Parkinson's disease. 11. Role of Probiotics in Amyotrophic lateral sclerosis (ALS) and Huntington's disease. 12. Role of Probiotics in MS, Epilepsy, and Seizures. 13. Role of Probiotics in Anxiety and Depression. 14. Role of Probiotics and Prebiotics in Ischemic Stroke in Connection with the Gut-Brain-Axis. 15. Role of probiotics: In ROS, inflammation mediated neurodegenerative diseases. 16. Correlation between Gut-Microbiome and Malnutrition and Other Factors in Neurological Disorders. 17. Tools and Bio-informatic Approaches to Study Gut Microbiota and Neurodegeneration. 18. Brain-gut Axis Focusing on High Throughput Technologies like Gene Sequencing, Brain Imaging and Metabolomics. 19. Signaling Pathways and Gut-Brain Axis: Relationship in Neurological Disorders. 20. Prebiotic as Functional Food in Neurological Disorder. 21. Postbiotics and Psychobiotics: Therapeutic Interventions in Neurodegenerative Diseases. 22. Gut-Microbiota Derived Bacterial Metabolites: Role in Neurological Disorders. 23. Therapeutic Applications of Prebiotics, Probiotics, and Postbiotics. 24. Nanocarriers encapsulated polyphenols, functional foods to modulate gut microbiota: In neurological disorders. 25. Probiotics as Nutraceuticals in Neurological Disorders. 26. Lifestyle and Environmental factors: Impact on Gut Microbiota and Neurological disorder. 27. Prebiotic, Probiotics and Postbiotics as a Complementary Therapy in the Management of Neurological Disorders: Clinical Trials and Case Studies. 28. Application of Artificial Intelligence in connection with Gut Microbiota to Detect Neurological Disorders. 29. Future Perspectives and Challenges of Probiotics, Prebiotic, and Postbiotics and Gut brain axis in Neurodegenerative disorders. 30. Regulatory concern of Prebiotics, Probiotics, Postbiotics and market growth in India.