Bipolar Disorder: Clinical and Neurobiological Foundations / Edition 1

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Bipolar disorder is the most complex psychiatric disorder with different types of mood episodes, subtypes, varied course, and significant co-morbidity. Not surprisingly, this complexity poses unique challenges to clinicians for optimal management of those with bipolar disorder.

There has been an explosion of research into the causes and treatment of this condition over the past two decades. It is a daunting task for a practising clinician to make sense of this research and to remain up to date with progress in the understanding of the neurobiology and treatment of bipolar disorder. This book synthesizes and translates the vast array of research knowledge into information that is clinically relevant and meaningful for a clinician.

The book provides a comprehensive, yet focused, reference work on bipolar disorder for both trainees and practising psychiatrists. The two editors are leaders in the field who have published extensively on bipolar disorder. They have assembled a team of experts from around the world: in many instances, chapters are co-authored by people from different continents, bringing a truly international perspective to this important topic. The book covers the basic science of the pathology underlying bipolar disorder but addresses the clinical aspects of the disease throughout.

The book comprises four sections:

  • Descriptive Aspects—issues ranging from how the concept of bipolar disorder has evolved over the years to new information about neurocognitive impairment, creativity and economic productivity, and to discussion of the deliberations of the DSM-V committee on changes in diagnostic categories and criteria.
  • Biology—the contribution of genes to this disorder, changes in circadian rhythms, what we know about brain changes and the role of oxidative stress.
  • Biological Treatment and Psychosocial Treatment— all the latest information about pharmacological and psychological treatments and the optimal management of this condition.

If you want to provide state-of-the-art care to your bipolar patients, be sure to consult this authoritative reference.

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Editorial Reviews

From the Publisher
"...The textbook is also an ideal starting point for trainees and young investigators just beginning to explore these subjects. Biopolar Disorder: Clinical and Neurobiological Foundations, then, is a useful addition to the library of most clinicians and academic psychiatrists" (Journal of Clinical Psychiatry, 2011)

"The book is a valuable guide to every psychiatrist. It contains a rich and wide range of information about bipolar disorder, step by step from criteria and definitions through biological changes to medical and psychotherapeutic treatment. The reader gets an overview over the newest findings which are presented in a very accessible way. It is definitely a book necessary for each modern psychiatrist!" (Acta Psychiatrica Scandinavica, 2011)

"Contributors to 38 chapters offer international perspectives on the disorder's clinical and neurobiological foundations as defined by the American Psychiatric Association's Diagnostic and Statistical Manual of Mental Disorders and the International Classification of Diseases." (SciTech Book News, December 2010)

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Product Details

  • ISBN-13: 9780470721988
  • Publisher: Wiley
  • Publication date: 11/30/2010
  • Edition number: 1
  • Pages: 522
  • Product dimensions: 8.70 (w) x 11.20 (h) x 1.30 (d)

Meet the Author

Dr. Yatham leads a Canadian consortium on bipolar disorder, testing new treatments for bipolar disorder using pragmatic and controlled trials with substantial funding from the Canadian Institutes of Health Research. He co-led the development of the Canadian guidelines for treatment of bipolar disorder in 1997; revised the guidelines for 2005 which were published with International Commentaries in Bipolar Disorders Journal. Dr Yatham is Chair of the bipolar group of the Canadian Network for Mood and Anxiety Treatments ; actively involved at a national and international level in continuing medical education and public education on diagnosis and treatment of bipolar disorder for psychiatrists, family physicians, and the general public. Currently the President for the International Society for Bipolar Disorders and on the editorial boards of a number of journals including Bipolar Disorders, Brain Pharmacology, Human Psychopharmacology, Quarterly Journal of Mental Health. He has published over 140 papers in peer-reviewed international journals and presented his research work at numerous international conferences. He was a recipient of the Michael Smith Foundation Senior Scholar Award (2001).

Professor Maj is President of the World Psychiatric Association; President of the Italian Psychiatric Association (since 2000); President of the Italian Society of Biological Psychiatry (since 1990); Association of European Psychiatrists Secretary-General (2001-2002) and President (2003-4); Editor of World Psychiatry and member of the Editorial Board of several scientific journals.

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Table of Contents

1, From Mania to Bipolar Disorder, David Healy

2, Clinical Features and Subtypes of Bipolar Disorder, Fred Goodwin and DZ Lieberman

3, The Long term Course and Outcome of Bipolar I and Bipolar II Disorder, Lewis Judd and Pamela J. Schettler

4, Comorbidity in Bipolar Disorder: A Focus on Addiction and Anxiety Disorders, Mark Frye and Guilio, Perugi

5, DSM-V Perspectives on Classification of Bipolar Disorder, Jan Fawcett

6, Update on the Epidemiology of Bipolar Disorder, Kathleen Merikangas and Tracy L. Peters

7, Suicide and Bipolar Disorder, Zoltan Rihmer and Jan Fawcett

8, Neurocognition in Bipolar Disorder, Ivan Torres and Gin Malhi

9, The Genius-Insanity Debate: Focus on Bipolarity, Temperament, Creativity and Leadership, Hagop Akiskal and Kareen K. Akiskal

10, Economics of Bipolar Disorder, Paul E., McCrone, R. Sabes-Figuera and D. Razzouk

11, An introduction to the neurobiology of bipolar illness onset, recurrence and progression, Robert Post and Marcia Kauer-Sant’Anna

12, Genetics of Bipolar Disorder, Wade Berrettini and Falk Lohoff

13, Structural Brain Imaging in Bipolar Disorder, Jair Soares and Paolo Brambilla

14, Functional Magnetic Resonance Imaging, Diffusion Tensor Imaging, and Magnetic Resonance Spectroscopy in Bipolar Disorder, Perry Renshaw and Inkyoon, Lyoo

15, Functional Brain Imaging Studies in Bipolar Disorder: Focus on Cerebral Metabolism and Blood Flow, John Brooks, Terry Ketter and Po W. Wang

16, Neurotransmitter Systems in Bipolar Disorder, John H. Krystal, Zubin Bhagwagar and Marina Nakic

17, Molecular Biology of Bipolar Disorder, Trevor Young, Ana Andreazza and Jun Feng Wang

18, Mitochondrial Dysfunction and Oxidative Stress, Michael Berk, Tadafumi Kato and Flavio Kapczinski

19, Neuroendocrinology of Bipolar Illness, Timothy Dinan and Michael Bauer

20, Circadian Rhythms and Sleep in Bipolar Disorder, Greg, Murray and Allison Harvey

21, Treatment Adherence in Bipolar Disorder, Jan Scott

22, Acute Mania, Paul E. Keck Jnr, Susan L., McElroy and   John M., Hawkins

23, Pharmacological Treatment of Bipolar Depression, Allan Young and Charles Nemeroff

24, Maintenance Treatment, Allan Swann

25, Rapid Cycling Bipolar Disorder: Phenomenology and Treatment, Joe Goldberg and Michael Berk

26, Management of Bipolar II Disorder, Gordon Parker and Terry Ketter

27, Management of Comorbidity in Bipolar Disorder, Ihsan Salloum, Tiffany Cooke and Luca Pani

28, Bipolar disorder and safety monitoring for clinicians in 2009: A review of the evidence and the implications, Mauricio Tohen and Chris,Bushe

29, Somatic Treatments for Bipolar Disorder, Mark George NB THIS CHAPTER DUE ON 30TH NOV

30, Novel Therapeutic Strategies for Bipolar Disorder, Carlos Zarate, Husseini Manji and Rodrigo Machado-Vieira

31, Psychoeducation as a core element of psychological approaches for Bipolar Disorder, Francesc Colom and Lesley Berk

32, Cognitive-Behavioural Therapy for Bipolar Disorder, Sagar Parikh and Jan Scott

33, Interpersonal and Social RhythmTherapy for Bipolar Disorder, Ellen Frank, Holly Swartz, Laura Zajac and David Kupfer

34, Family therapy approaches to Bipolar Disorder, David J. Miklowitz

35, Collaborative Care for Bipolar Disorder, Amy M., Kilbourne, Mark S.Bauer and David E.Goodrich

36, Bipolar Disorder in Women, Meir Steiner, Benecio N. Frey, Claudio N. Soares and Karen A. Macritchie

37, Phenomenology and Treatment of Bipolar I Disorder in Children: A Critical Review, Gabrielle Carson

38, Bipolar Disorder in the Elderly, Martha Sajatovic and Lars Vedel Kessing

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