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Bipolar Disorders: Basic Mechanisms and Therapeutic Implications
     

Bipolar Disorders: Basic Mechanisms and Therapeutic Implications

by Gershon Samuel (Editor), Jair C. Soares (Editor)
 

Over the past two decades, driven by the enormous public health importance of bipolar disorder, research initiatives have begun to elucidate the pathophysiology of this prevalent and debilitating condition. These research initiatives have led to breakthroughs in our understanding of causation, and now promise to foster the development of novel treatments. This new

Overview

Over the past two decades, driven by the enormous public health importance of bipolar disorder, research initiatives have begun to elucidate the pathophysiology of this prevalent and debilitating condition. These research initiatives have led to breakthroughs in our understanding of causation, and now promise to foster the development of novel treatments. This new edition presents contributions from the leaders at the forefront of these areas of research, and includes chapters on the groundbreaking advances in the fields of genetics, neuroimaging, neuropsychopharmacology, oxidative stress and neuronal resilience, inflammatory mechanisms, psychosocial factors, childhood onset and late-life bipolar disorder, and many other important areas. Throughout, the therapeutic implications and potential of this new understanding are emphasized. This will be essential reading for those interested in the neurobiology of mental illness, and will be of interest to mental health practitioners more generally.

Editorial Reviews

Doody's Review Service
Reviewer: Michael Joel Schrift, DO, MA (Northwestern University Feinberg School of Medicine)
Description: This is an excellent, comprehensive, and up-to-date book on the biological aspects of bipolar disorder. Written and edited by internationally well-known leading clinician-researchers in the field, it is an outstanding contribution to psychiatry.
Purpose: The purpose, according to the editors, is to provide a comprehensive book focused specifically on the biological underpinnings of bipolar mood disorder. The editors have gathered outstanding contributions from leading researchers in the various fields of biological psychiatry.
Audience: The intended audience is psychiatrists, researchers, and trainees in psychiatry as well as graduate and postgraduate students in neuroscience.
Features: There are 580 pages, divided into 26 chapters. Topics covered include classification in bipolar disorder, secondary mania, genetic and causal factors, cyclic end oscillatory behaviors in bipolar disorder, and chapters on catecholamines, serotonin, and GABA in bipolar disorder. Other interesting topics include postmortem studies, brain imaging, viral theories, sensitization and kindling, and a summarizing chapter on the pathophysiology of bipolar disorder. Each chapter is well referenced and the index is quite useful.
Assessment: This is an outstanding book on the latest findings and theories of the neurobiology of bipolar disorder; I highly recommend it to anyone involved in this field.
4 Stars! from Doody
David J. Kupfer
introduces new approaches to understanding the pathophysiology of bipolar disorder.
Polymer News
...contain[s] a good amount of useful information and a number of well-written papers on current subjects of interest in this field and is worthy of review by those involved in the filed.
Michael J. Schrift
This is an excellent, comprehensive, and up-to-date book on the biological aspects of bipolar disorder. Written and edited by internationally well-known leading clinician-researchers in the field, it is an outstanding contribution to psychiatry. The purpose, according to the editors, is to provide a comprehensive book focused specifically on the biological underpinnings of bipolar mood disorder. The editors have gathered outstanding contributions from leading researchers in the various fields of biological psychiatry. The intended audience is psychiatrists, researchers, and trainees in psychiatry as well as graduate and postgraduate students in neuroscience. There are 580 pages, divided into 26 chapters. Topics covered include classification in bipolar disorder, secondary mania, genetic and causal factors, cyclic end oscillatory behaviors in bipolar disorder, and chapters on catecholamines, serotonin, and GABA in bipolar disorder. Other interesting topics include postmortem studies, brain imaging, viral theories, sensitization and kindling, and a summarizing chapter on the pathophysiology of bipolar disorder. Each chapter is well referenced and the index is quite useful. This is an outstanding book on the latest findings and theories of the neurobiology of bipolar disorder; I highly recommend it to anyone involved in this field.
Booknews
Soares and Gershon (both in psychiatry, U. of Pittsburgh School of Medicine) present 26 chapters which explore recent research related to the neurobiology and therapeutics of manic depression. Among other topics, chapters are included on genetics, neuroimaging, investigations of signal transduction abnormalities, potential interactions between biology and psychosocial factors, and childhood- onset and late-life bipolar disorder. Annotation c. Book News, Inc., Portland, OR (booknews.com)

Product Details

ISBN-13:
9780824703608
Publisher:
Taylor & Francis
Publication date:
01/28/2000
Series:
Medical Psychiatry Series
Edition description:
New Edition
Pages:
600
Product dimensions:
6.25(w) x 9.25(h) x 1.25(d)

Related Subjects

What People are Saying About This

David J. Kupfer
From the Foreword...
...fills a huge gap and provides a template for research in bipolar [disorders]. The state-of- the-art reviews and prospects for future research are written by a distinguished group of experts in their field....
...provides the most comprehensive reference of the biological aspects of bipolar disorders and implications for intervention.
...introduces new approaches to understanding the pathophysiology of bipolar disorder.
—(David J. Kupfer, M.D. Thomas Detre Professor and Chair Department of Psychiatry Director of Research Western Psychiatric Institute and Clinic University of Pittsburgh School of Medicine Pennsylvania)

Meet the Author

Jair C. Soares is Professor and Chairman of the Department of Psychiatry and Behavioral Sciences at the University of Texas Health Science Center in Houston. He is also Director of the UT Center of Excellence on Mood Disorders. Between 1998 and 2002, he co-edited the journal Bipolar Disorders: An International Journal of Psychiatry and Neurosciences and he is currently the joint Editor-in-Chief of the Journal of Affective Disorders. He has published more than 200 peer-reviewed manuscripts, and has also edited three textbooks: Brain Imaging Investigations on Affective Disorders, Bipolar Disorders: Basic Mechanisms and Therapeutic Implications, and Handbook of Medical Psychiatry.

Allan H. Young holds the Chair of Mood Disorders at King's College London where he is also Director of the Centre for Affective Disorders within the Department of Psychological Medicine in the Institute of Psychiatry. He has published over 300 peer-reviewed publications and a number of books about psychopharmacology and affective disorders, including Bipolar Disorders: Basic Mechanisms and Therapeutic Implications and Practical Management of Bipolar Disorder. He is currently President of the International Society for Affective Disorders and Chair of the Psychopharmacology Special Committee of the Royal College of Psychiatrists.

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