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Bipolar Disorders: Basic Mechanisms and Therapeutic Implications

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Responding to the explosion of research on the pathophysiology and management of bipolar disorder, this completely revised Second Edition spans basic mechanisms, neuroimaging, viral etiology, neurofactors, current treatment implications, and modern theories of the neurobiology of bipolar disorder to stand as the most authoritative reference on this debilitating condition. Written and edited by internationally lauded experts in the field, this source covers an expansive array of topics including genetic and causal...

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Overview

Responding to the explosion of research on the pathophysiology and management of bipolar disorder, this completely revised Second Edition spans basic mechanisms, neuroimaging, viral etiology, neurofactors, current treatment implications, and modern theories of the neurobiology of bipolar disorder to stand as the most authoritative reference on this debilitating condition. Written and edited by internationally lauded experts in the field, this source covers an expansive array of topics including genetic and causal factors, neuroendocrinology, neurotransmitters and signal transduction pathways, neuroimaging and neurorecognition, and prospects for new treatment development.

The book contains black-and-white illustrations.

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Editorial Reviews

Doody's Review Service
Reviewer: Michael Joel Schrift, D.O., M.A.(University of Illinois at Chicago College of Medicine)
Description: This is an excellent, comprehensive, and up-to-date book on the biological aspects of bipolar disorder. Written and edited by internationally well-known leading clinician-researchers in the field, it is an outstanding contribution to psychiatry.
Purpose: The purpose, according to the editors, is to provide a comprehensive book focused specifically on the biological underpinnings of bipolar mood disorder. The editors have gathered outstanding contributions from leading researchers in the various fields of biological psychiatry.
Audience: The intended audience is psychiatrists, researchers, and trainees in psychiatry as well as graduate and postgraduate students in neuroscience.
Features: There are 580 pages, divided into 26 chapters. Topics covered include classification in bipolar disorder, secondary mania, genetic and causal factors, cyclic end oscillatory behaviors in bipolar disorder, and chapters on catecholamines, serotonin, and GABA in bipolar disorder. Other interesting topics include postmortem studies, brain imaging, viral theories, sensitization and kindling, and a summarizing chapter on the pathophysiology of bipolar disorder. Each chapter is well referenced and the index is quite useful.
Assessment: This is an outstanding book on the latest findings and theories of the neurobiology of bipolar disorder; I highly recommend it to anyone involved in this field.
David J. Kupfer
introduces new approaches to understanding the pathophysiology of bipolar disorder.
Polymer News
...contain[s] a good amount of useful information and a number of well-written papers on current subjects of interest in this field and is worthy of review by those involved in the filed.
Michael J. Schrift
This is an excellent, comprehensive, and up-to-date book on the biological aspects of bipolar disorder. Written and edited by internationally well-known leading clinician-researchers in the field, it is an outstanding contribution to psychiatry. The purpose, according to the editors, is to provide a comprehensive book focused specifically on the biological underpinnings of bipolar mood disorder. The editors have gathered outstanding contributions from leading researchers in the various fields of biological psychiatry. The intended audience is psychiatrists, researchers, and trainees in psychiatry as well as graduate and postgraduate students in neuroscience. There are 580 pages, divided into 26 chapters. Topics covered include classification in bipolar disorder, secondary mania, genetic and causal factors, cyclic end oscillatory behaviors in bipolar disorder, and chapters on catecholamines, serotonin, and GABA in bipolar disorder. Other interesting topics include postmortem studies, brain imaging, viral theories, sensitization and kindling, and a summarizing chapter on the pathophysiology of bipolar disorder. Each chapter is well referenced and the index is quite useful. This is an outstanding book on the latest findings and theories of the neurobiology of bipolar disorder; I highly recommend it to anyone involved in this field.
Booknews
Soares and Gershon (both in psychiatry, U. of Pittsburgh School of Medicine) present 26 chapters which explore recent research related to the neurobiology and therapeutics of manic depression. Among other topics, chapters are included on genetics, neuroimaging, investigations of signal transduction abnormalities, potential interactions between biology and psychosocial factors, and childhood- onset and late-life bipolar disorder. Annotation c. Book News, Inc., Portland, OR (booknews.com)

4 Stars! from Doody
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Product Details

  • ISBN-13: 9780824703608
  • Publisher: Taylor & Francis
  • Publication date: 1/28/2000
  • Series: Medical Psychiatry Series
  • Edition description: New Edition
  • Edition number: 1
  • Pages: 600
  • Product dimensions: 6.25 (w) x 9.25 (h) x 1.25 (d)

Table of Contents

The Classification of Bipolar Disorders - Implications for Clinical Research. Prospects for the Development of Animal Models for the Study of Bipolar Disorder. Abnormalities in Catecholamines and the Pathophysiology of Bipolar Disorder. Cholinergic Dysfunction in Mood Disorders. Serotonergic Dysfunction in Mood Disorders. Cell Membrane and Signal Transduction Pathways - Implications for the Pathophysiology of Bipolar Disorders. Post-Mortem Studies in Bipolar Disorder. Neuroendocrinology Abnormalities in Bipolar Disorder. Brain Imaging Abnormalities in Bipolar Disorder. Sleep and Biological Rhythms Abnormalities in the Pathophysiology of Bipolar Disorders. The Hypothesis of a Viral Etiology in Bipolar Disorders. Eegs and Erps in Bipolar Disorders. Genetic Factors in the Etiology of Bipolar Disorder. Neurocognitive Findings in Bipolar Disorder. Biology Versus Environment: The Role of Stressors in the Pathophysiology of Bipolar Disorder. The Kindling/Sensitization Model and the Pathophysiology of Bipolar Disorder. Biological Factors in Different Bipolar Disorder Sub-Types. Biological Factors in Bipolar Disorder in Childhood and Adolescence. Biological Factors in Bipolar Disorder in Late Life. Perspectives for New Pharmacological Interventions. Physical Health and Metabolic Dysfunction in Bipolar Disorder.Towards a Pathophysiology of Bipolar Disorder

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