Bladder Disease: Research Concepts and Clinical Applications / Edition 1

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This volume is the proceedings of the International Bladder Symposium held November 4-7, 1999, in Washington D.C., sponsored by the National Bladder Foundation and the National Institute of Diabetes, Digestive, and Kidney Diseases. This volume will provide a forum for authoritative investigators who are actively involved in the various disciplines which define the leading edges of bladder research. The topics covered are divided into five sections: 1) Oncology and Cellular Biology, 2) New Frontiers and Therapies, 3) Inflammation and Infection, and 5) Muscle Matrix and Obstruction.

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Table of Contents

1 Recent Developments in the Treatment of Bladder Cancer 3
2 Interferon-[alpha] Response and Signal Transduction Pathway in Transitional Carcinoma Cell Lines 15
3 Molecular Cloning and Expression of Uroplakins in Transitional Cell Carcinoma 33
4 Application of a Novel Protein Chip Mass Spectrometry Technology for the Identification of Bladder Cancer-Associated Biomakers 47
5 The Photodynamic Diagnosis (PDD) for Early Detection of Carcinoma and Dysplasia of the Bladder 61
6 Prediction of Lymph Node Metastasis Based on P53 and nm23-H1 Expression in Muscle Invasive Grade III Transitional Cell Carcinoma of Bladder 67
7 Detection of HER-2/neuCEP 17 Mutations at Invasive Bladder Cancer 87
8 Ki67, P53, nm23, and DNA Cytometry in Bladder Cancer: Potential Markers for Detection of Recurrence? 99
9 Comparison of Cytology and Nuclear Matrix Protein 22 (NMP 22) for the Detection and Follow-Up of Bladder Cancer 111
10 The Effect of Contrast Material on Transitional Cell Carcinoma Viability 121
11 Flurodeoxyglucose Positron Emission Tomography Studies in the Diagnosis and Staging of Transitional Cell Carcinoma 129
12 Radiochemotherapy in Locally Invasive Non-Metastatic Carcinoma of the Bladder 143
13 Gene and Antisense Therapy of Bladder Cancer 155
14 Tumor Suppressor Genes of Bladder Cancer and Potential for Gene Therapy 185
15 Molecular Response of the Bladder to Obstruction
16 The Role of Lipids and Lipid Metabolites in Urinary Bladder Dysfunction Induced by Partial Outlet Obstruction 217
17 Intercellular Communication and Bladder Function
18 Ischemia as an Etiological Factor in Bladder Instability: Implications for Therapy 255
19 Effect of Chronic Ischemia on Bladder Structure and Function 271
20 Ultrastructural Diagnosis of Neuropathic Detrusor Overactivity: Validation of a Common Myogenic Mechanism 281
21 Serial Changes of Smooth Muscle Cell Phenotypes in Rat Urinary Bladder Following Partial Outflow Obstruction 293
22 Study of Detrusor Dysfunction Due to Outlet Obstruction: Link Between Analysis of Uroflows of Men with Benign Prostatic Hyperplasia and Animal Studies 297
23 Ultrasonic Measurement of Bladder Weight as a Novel Urodynamic Modality 311
24 Experimental Neurogenic Cystitis 319
25 Murine In Vitro Whole Bladder Physiology 337
26 Ca[superscript 2+] Sparks and K[subscript Ca] Channels: Novel Mechanisms to Relax Urinary Bladder Smooth Muscle 347
27 The Effect of Intravesical Capsaicin and Resiniferatoxin in Neurogenic Bladder Dysfunction 359
28 On the Physioanatomy of Micturition and Urinary Continence - New Concepts 381
29 Stress Urinary Incontinence: New Concept of Pathogenesis and Treatment by Pudendal Canal Decompression 415
30 Transcutaneous Electrovesicogram in Normal Volunteers and Patients with Interstitial Cystitis, Neurogenic Bladder, Benign Prostatic Hyperplasia, and after Cystectomy 441
31 Extracorporeal Electromagnetic Stimulation for Urinary Incontinence and Bladder Disease 453
32 Pubovaginal Sling Surgery without Using Abdominal Leak Point Pressure: An Outcomes Analysis 467
33 The Use of Synthetic Materials in Pubovaginal Sling 481
34 Surgical Implantation of the Synthetic Sling (The 6-Point Fixation Technique and Weight-Adjusted Spacing Nomogram): Technique and Results 493
35 Reconstructive Surgery in Neuropathic Bladder 509
36 The Role of the Simple Cystectomy in Urologic Surgery 535
37 Neurogenic Inflammation of the Bladder 551
38 Urine-Induced Apptosis in Cultured Bladder Urothelial Cells 585
39 Bacillus of Calmette and Guerin Modulates Nuclear Factor Kappa [beta] in Two Urothelial Carcinoma Cell Lines 599
40 Induction of Urothelial Cell Proliferation by Fibroblast Growth Factor-7 in RAGI-Deficient Mice 623
41 Development of a Recombinant FimCH Vaccine for Urinary Tract Infections 635
42 Intravesicular Pain Mapping 655
43 A Hypothesis for the Etiology of Interstitial Cystitis 683
44 Pentosanpolysulfate (Elmiron) is a Potent Inhibitor of Mast Cell Histamine Secretion 713
45 The Efficacy of Intravesicular Sterile Sodium Chondroitin Sulfate 0.2% in Potassium Tested Positive Patients with Interstitial Cystitis 731
46 Cystectomy Causes Immunosuppression in Bladder Cancer 741
47 Nocturia 751
48 The Fate of Urinary Bladder Smooth Muscle after Outlet Obstruction - A Role for the Sarcoplasmic Reticulum 773
49 Alteration of Collagen Three-Dimensional Architecture in Noncompliant Human Urinary Bladder 791
50 Modulation of Angiogenesis: Experimental Strategies and Potential Therapeutic Applications 803
51 Methods of Testing Urethral Resistance in the Female Rat 831
52 Virtual Reality Surgical Simulation for Lower Urinary Tract Endourologic Surgery 841
53 Autologous Muscle Transfer for Reconstruction of the Lower Urinary Tract 853
54 Effectiveness of Denuding the Intestinal Mucosa by Submucosal Injection in the Porcine Model 869
55 Urinary Diversion in the Management of Chronic Perineal Skin Ulceration in Spinal Cord Injured Patients Following Sphincterotomy 879
56 The Artificial Urinary Bladder 885
57 Comparison of the Breaking Strength of Polyglactin Mesh in Urine, Serum, and Cell Culture Media 895
58 Growth of Cultured Human Urothelial Cells Into Stratified Urothelial Sheet Suitable for Autografts 907
59 Future Perspectives in Bladder Reconstruction 921
Subject Index 941
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