Blistering Skin Diseases

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More About This Textbook


This book aims to provide the definitive guide to the diagnosis and treatment of various blistering skin diseases. It offers the reader a succinct clinical description for quick recognition of different types of blistering diseasess and their relative urgency. It also provides information on the clinical features of blistering skin diseases, differentrial diagnoses, laboratory findings, and therapeutic strategy. This book will be useful for dermatologists in training and in practice, physicians workin gin emergency departments, and in medical microbiology, immunology, and infectious disease.

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Product Details

  • ISBN-13: 9781555815202
  • Publisher: ASM Press
  • Publication date: 3/30/2009
  • Pages: 160
  • Product dimensions: 7.50 (w) x 10.50 (h) x 0.60 (d)

Table of Contents

Preface 5

Chapter 1 Overview of Blistering Skin Diseases

Mechanisms of Blister formation 7

Classification of diseases 8

Strategies for diagnosing diseases 10

Chapter 2 Diagnostic Methods

Methods of skin biopsy 14

Biopsy for routine histopathology 14

Biopsy for direct immunofluorescence microscopy 14

Biopsy for transmission electron microscopy 15

Biopsy for immunotransmission electron microscopy 15

Biopsy for immunomapping 15

Histopathology 15

Immunofluorescence microscopy 17

Direct immunofluorescence 17

Indirect immunofluorescence 18

Immunomapping 19

Immunoblotting 20

Immunoprecipitation 21

Elisa 21

Transmission electron microscopy 22

Regular transmission electron microscopy 22

Immunotransmission electron microscopy 22

Genetic mutation analysis 23

Chapter 3 Autoimmune Diseases

Intraepidermal Diseases 26

Pemphigus vulgaris 26

Pemphigus vegetans 30

Pemphigus foliaceus 33

Pemphigus erythematosus 36

Pemphigus herpetiformis 38

IgA-mediated pemphigus 40

Paraneoplastic pemphigus 43

Sub-epidermal diseases 46

Bullous pemphigoid 46

Lichen planus pemphigoides 49

Pemphigoid vegetans 50

Pemphigoid nodularis 52

Pemphigoid gestationis (herpes gestationis) 54

Mucous membrane Pemphigoid 56

Linear IgA Bullous dermatosis 60

Chronic bullous dermatosis of childhood 62

Epidermolysis bullosa acquisita 65

Bullous systemic lupus erythematosus 68

Chapter 4 Heritable Diseases

Intraepidermal diseases 82

Familial benign pemphigus (Hailey-Hailey disease) 82

Incontinentia pigmenti 84

Suprabasal intraepidermal diseases (simplex form epidermolysis bullosa) 87

Lamina lucida subepidermal diseases (junctional form epidermolysisbullosa) 91

Sublamina densa subepidermal diseases (dystrophic form epidermolysis bullosa) 95

Recessive epidermolysis bullosa dystrophica 95

Dominant epidermolysis bullosa dystrophica 99

Chapter 5 Inflammation-Mediated Diseases

Dermatities herpetiformis 106

Erythema multiforme/Stevens-Johnson syndrome/toxic epidermal necrolysis 109

Vesicular palmoplantar eczema (dyshidrosis) 114

Allergic contact dermatitis 115

Subcorneal pustular dermatosis (Sneddon-Wilkinson disease) 117

Bullous eruption to insect bites 119

Erythema toxicum neonatorum 120

Chapter 6 Metabolic Diseases

Porphyria cutanea tarda 125

Bullosis diabeticorum 128

Chapter 7 Infection-Mediated Diseases

Bullous impetigo/Staphylococcal scalded-skin syndrome 130

Herpes simplex 133

Herpes zoster (shingles) 136

Hand-foot-mouth disease 139

Bullous congenital syphilis 140

Bullous dermatophyte infections 142

Chapter 8 Palmar Plantar Pustular Dermatoses

Infantile acropustulosis 146

Palmoplantar pustulosis 147

Chapter 9 Partially Characterized Blistering Dermatoses

Anti-p105 pemphigoid 150

Anti-p200 pemphigoid 152

Glossary of abbreviations 156

Index 158

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