Blood Disorders in the Elderly

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The developed world has an increasingly aging population, with approximately 10% of the population aged over 65 years. As the incidence and prevalence of blood disorders increases with age, these conditions are a heavy burden on healthcare systems. Blood Disorders in the Elderly will provide hematologists, geriatricians and all clinicians involved in the care of patients with blood disorders with clear clinical advice on the diagnosis and management of these conditions. The introductory section reviews epidemiology of aging and anaemia and provides a comprehensive approach to the management of cancer in the aging patient. This is followed by a full discussion of hemopoiesis and changes it undergoes in aging. The remaining sections cover the diagnosis and management of all major disorders: anaemia, malignancy, coagulation and platelet disorders and hemophilia. A detailed chapter on antithrombotic therapies is also included.

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Editorial Reviews

From the Publisher
'This is a brilliant contribution to the field. The excellent organisation of the book is matched by superb editing that provides an even tone of voice often lacking in multi-authored books. … This book will be the lodestone that directs future research in the haematology of old age.' David O. Staats, University of Oklahoma Health Sciences Center

'Haematologic disorders, covering from mild to severe diseases are part of everyday practice in geriatric wards. For this reason this book could be welcome on the shelves of geriatricians dealing with internal medicine. … The subject of this book, if covered in detail, could fill an encyclopaedia. The authors managed to treat the…topics in a comprehensive manner, limiting thereby the volume of this treatise. The texts are written in an easily understandable style… The chapter headings…show clearly that the chosen topic is well covered, For these reasons this book is highly recommended for geriatric clinical practitioners.' Gerontology 2008

Doody's Review Service
Reviewer: David O. Staats, MD (University of Oklahoma Health Sciences Center)
Description: This multiauthored book reviews blood and blood disorders in old age. It melds aging with blood disorders in an exceptionally thorough way.
Purpose: The purpose is to review how knowledge of aging and blood disorders combines to give a comprehensive look at hematology in old age. The book fulfills its goals handsomely.
Audience: The audience is clinicians who treat and evaluate blood disorders in older persons as well as researchers who look at blood, immune function, tumors, and the mysterious world of mesenchymal tissues of which blood is archetypal. The editors have gathered an international group of authors, all of them experts in the field.
Features: The first of the book's five sections is on epidemiology and gives a precis of aging. The second part discusses hematopoiesis and contains some of the most interesting chapters in the book. The third part covers the anemia of aging. The fourth part explores hematologic malignancies in old age. The fifth part on disorders of hemostasis in old age includes excellent chapters on antithrombotic therapy and the hypercoagulability observed in old age. There are superb color plates in the middle of the book and the chapters have some of the best illustrations and diagrams I've seen.
Assessment: This is a brilliant contribution to the field. The excellent organization of the book is matched by superb editing that provides an even tone of voice often lacking in multiauthored books. The information in these chapters will beguile you. In fact, the bone and bone marrow are more alike than different, as discussed in a superb chapter on the microenvironment of the bone marrow. The chapter on hematopoiesis shows how difficult it is to measure kidney function with age and therefore to gauge deficits in erythropoietin elaboration. The chapter on hemostasis explains why aging is a hypercoagulable state. This book deserves wide and thoughtful readership. It will stimulate researchers to look at the effects of exercise on blood. If exercise is both trophic for the bone and antiapoptotic, shouldn't exercise also be trophic for the erythron? This book will be the lodestone that directs future research in the hematology of old age.
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Product Details

  • ISBN-13: 9780521875738
  • Publisher: Cambridge University Press
  • Publication date: 12/31/2007
  • Pages: 496
  • Product dimensions: 7.44 (w) x 9.69 (h) x 1.10 (d)

Meet the Author

Lodovico Balducci is the Division Chief of the Senior Adult Oncology Program at the H. Lee Moffitt Cancer Center and Research Institute, Tampa, and Professor of Oncology and Medicine.

William Ershler is Director of the Institute for Advanced Studies in Aging and Geriatric Medicine, Washington DC.

Giovanni de Gaetano is Director of the Research Laboratories at the Centre for High Technology Research and Education in Biomedical Sciences, Catholic University, Campobasso, Italy.

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Table of Contents

Introduction; Part I. Epidemiology: 1. Epidemiology of aging Lodovico Balducci and William B. Ershler; 2. Epidemiology of anemia: older adults Kushang V. Patel and Jack M. Guralnik; 3. Cancer in the older person: a comprehensive approach Oscar A. Cepeda, Julie K. Gammack and John E. Morley; 4. From fitness to frailty: toward a nosologic classification of the older aged person Lodovico Balducci and Claudia Beghe; Part II. Hemopoiesis: 5. Stem cell exhaustion and aging Gary Van Zant; 6. Hemopoietic micro-environment and age David N. Haylock and Susan K. Nilsson; 7. Replicative senescence, aging, and cancer Rita Effros; 8. Qualitative changes of hemopoiesis France Laurencet and Gilbert Zulian; 9. Aging and hemopoietic stress Lodovico Balducci and Cheryl Hardy; 10. Immunoglobulin response and aging Yuping Deng and Stefan Gravenstein; 11. Biological and clinical significance of monoclonal gammopathy Arati V. Rao and Harvey J. Cohen; Part III. Anemia of Aging: 12. Erythropoietin and aging Andrew S. Aartz; 13. Iron and aging E. Nemeth and Tomas Ganz; 14. Prevalence and mechanism of B12 deficiency Sally P. Stabler; 15. The consequences of anemia Luigi Ferrucci and Dan L. Longo; 16. The pathogenesis of late-life anemia Bindu Kanapuru and William B. Ershler; 17. Treatment of late-life anemia William B. Ershler; Part IV. Hematological Malignancies and Aging: 18. Cancer chemotherapy in the older person Lodovico Balducci; 19. Acute myeloid leukemia in the elderly Magda Elkabani and Jeffrey Lancet; 20. Acute lymphoblastic leukemia in elderly patients: diagnosis and therapy Salvatore Bruno, Femina Mazzella and Oscar Ballester; 21. Multiple myeloma Todd J. Alekshun and Melissa Alsina; 22. Non-Hodgkin lymphoma Nicole Jacobi and Bruce A. Peterson; 23. Unusual lymphomas in the elderly Youssef Gamal, Samuel Kerr and Thomas P. Loughran; 24. Chronic lymphocytic leukemia in the elderly Alexander S. D. Spiers; 25. Polycythemia vera and idiopathic myelofibrosis in the elderly Jerry L. Spivak; Part V. Disorders of Hemostasis in the Elderly: 26. Acquired hemophilia in the elderly F. Baudo and F. de Cataldo; 27. Blood coagulation and aging Jozef Vermylen and Marc F. Hoylaerts; 28. Platelet disorders in the elderly Laura Terranova, Giancarla Gerli and Marco Cattaneo; 29. Gene-environment interactions and vascular risk in the elderly Daniela Mari; 30. Antithrombotic therapy: guidelines for the elderly Chiara Cerletti, H. J. Schunemann and Giovanni de Gaetano.

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