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Bone and Cancer / Edition 1

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Bone and Cancer is the fifth volume in the series Topics in Bone Biology, edited by Felix Bronner and Mary C. Farach-Carson. This title features current knowledge on mechanisms of metastasis, the role of the bone microenvironment in cancer progression, how inflammatory cytokines function in metastasis and osteolysis, and the role of osteoblasts, thus bringing to the clinician and researcher cellular and molecular findings that affect the search for drugs and lead to translational studies.

Each chapter contains an extensive bibliography that permits readers to learn more about specific aspects of the chapter topic. Tables, diagrams and figures illustrate and clarify cellular events that lead to development and progression of cancer in bone. Insights based on cellular and molecular events clarify the clinical picture and may lead to translational research and focused therapy. The chapters, authored by authorities from throughout the world, emphasize how current knowledge can lead to better treatement.

Other titles in this series:-

Bone Formation

Bone Resorption

Engineering of Functional Skeletal Tissues

Bone and Osteoarthritis

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Editorial Reviews

Doody's Review Service
Reviewer: Mark R Hutchinson, MD (University of Illinois at Chicago College of Medicine)
Description: A volume in the Topics in Bone Biology series, this book covers the basic science and translational and clinical aspects of bone cancer and bone tumors.
Purpose: The authors proudly note in the preface that this volume is the outcome of a collaboration of clinicians from several specialties and scientists of diverse orientation and illustrates the importance of a multispecialty, multidisciplinary approach to bone cancer. The ultimate goal is to bring the current knowledge together in one book while recognizing that the future direction of treatment for bone cancer lies in a multidisciplinary approach. These are worthy objectives and essential to the future of cancer treatment.
Audience: The target audience is clearly an elite group of clinicians and scientists who are focused on understanding future innovations in the treatment of bone related cancers. Residents in training will find the book deeply scientific and an intense read of the basic science and concepts of bone cancer. It is probably more in depth than the average orthopedic surgeon would need for a cursory review of bone cancer, but it would be a great addition to the lab that is studying bone cancers or for the clinician who is actively treating patients with bone cancer.
Features: The 16 chapters focus on unique aspects of bone cancer ranging from genetics, detection, and mechanism of metastasis to molecular imaging and assessment of what is going on in the microenvironment of bone cancer. Each chapter is accompanied by an extensive and valuable list of references that readers can delve into more deeply if they wish to study a topic in more depth.
Assessment: This excellent book brings together basic science and key clinical issues with some of the best experts of the field of bone cancers. It will be a welcome read for specialists in the field. As great as it is in its targeted focus on a complicated subject, the average orthopedist will find in deeper scientifically than is necessary for a general orthopedic practice. It clearly is targeted at specialists or scientists in the field.
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Product Details

  • ISBN-13: 9781848820180
  • Publisher: Springer London
  • Publication date: 8/6/2009
  • Series: Topics in Bone Biology Series , #5
  • Edition description: 2009
  • Edition number: 1
  • Pages: 246
  • Product dimensions: 7.00 (w) x 10.00 (h) x 0.60 (d)

Meet the Author

Series Editors of Topics in Bone Biology are: Professors Felix Bronner, PhD - University of Connecticut Health Center, Farmington, CT, USA, and Dr Mary C. Farach-Carson, PhD - the Department of Biology, University of Delaware, Newark, DE, USA

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Table of Contents

Blood–Bone Axis and Bone Marrow Microenvironment.- Genetics of Osteosarcoma.- Multiple Myeloma and Other Hematological Malignancies of Bone.- Mechanism of Metastasis to Bone: The Role of Bone Marrow Endothelium.- Lysophosphatidic Acid: Role in Bone and Bone Cancer.- Role of Bone Microenvironment/Metastatic Niche in Cancer Progression.- Detection and Characterization of Disseminated Tumor Cells present in Bone Marrow of Cancer Patients.- Molecular Imaging of Cancer Cells Growing in Bone.- Inflammatory Cytokines and Their Role in Bone Metastasis and Osteolysis.- Prostate Cancer Bone Colonization: Osteomimicry in the Bone Niche.- Bone Pain Associated with Cancer Metastasis.- Small Animal Models for the Study of Cancer in Bone.- Hormonal therapies in Breast and Prostate Cancer: Effects on Bone and the Role of Bisphosphonates.- Therapeutic Approaches to Metastatic Bone Cancer II: Targeted and Non-targeted Systemic Agents.- The Role of Allogeneic Bone Marrow Transplant in Cancer Treatment.- The Role of Radiosurgery in the Treatment of Bone Localized Cancers.

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