Bone and Development / Edition 1

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More About This Textbook


This volume, the sixth in the series Topics in Bone Biology, presents the current knowledge of bone development, from growth to mineralization. Like previous volumes in this series, it embraces the important interaction between medical science and practice. Insights stemming from molecular and cellular events are applied to the clinical setting, providing a deeper understanding of bone development complications for the practicing clinician, whilst informing bone scientists of the advancements in their field and the wider applications of their research. Covering a diverse and current range of topics, including the genetic and epigenetic aspects of bone development, cell signaling in growth plate and bone development, evolution of bone proteins and the interrelationship between bone and other tissues, this volume provides a thorough look at bone development biology. The contributing authors to this volume are acknowledged authorities in their fields. In addition, the extensive lists of references point the reader to further information on any of the topics covered. Clinicians and researchers involved in child development and therapy will find this book a valuable addition to their libraries.

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Product Details

  • ISBN-13: 9781848828216
  • Publisher: Springer London
  • Publication date: 12/21/2009
  • Series: Topics in Bone Biology, #6
  • Edition description: 2010
  • Edition number: 1
  • Pages: 305
  • Product dimensions: 7.70 (w) x 10.30 (h) x 1.10 (d)

Table of Contents

Preface v

Contributors xiii

Abbreviations xix

1 Genetic and Epigenetic Aspects of Bone Development Rose D. O'Connor Mary C. Farach-Carson N. Carolyn Schanen 1

2 Tissue Interactions in Long Bone Development CĂ©line Colnot Tamara Alliston 25

3 The Epiphyseal Growth Plate H. Clarke Anderson Irving M. Shapiro 39

4 Hedgehog Signaling in Growth Plate and Bone Development Jean B. Regard Kingston K. Mak Joshua A. Gordon Yingzi Yang 65

5 Role of microRNA in Skeleton Development Ben Gradus Eran Hornstein 81

6 FGF/FGFR Signaling in Skeletal Dysplasias Pierre J. Marie 93

7 The Role of Hypoxia-Induced Factors Ernestina Schipani Richa Khatri 107

8 BMP Signaling in Skeletogenesis Kristine D. Estrada Karen M. Lyons 125

9 Wnt Signaling in Bone Development Peter V. N. Bodine 137

10 Development of the Craniofacial Complex Rena N. D'Souza L-Bruno Ruest Robert J. Hinton Kathy K. H. Svoboda 153

11 Dentin and Bone: Similar Collagenous Mineralized Tissues Mary J. MacDougall Amjad Javed 183

12 Evolution of Bone Proteins Eddie Wang Seung-Wuk Lee 201

13 Osteogenesis Imperfecta Paul Arundel Nicolas J. Bishop 215

14 Fibrodysplasia Ossificans Progressiva: Developmental Implications of a Novel Metamorphogene Frederick S. Kaplan Jay C. Groppe Petra Seemann Robert J. Pignolo Eileen M. Shore 233

15 Bone-Mineral Homeostasis and Associated Pathologies Meinrad Peterlik 251

16 Interrelationship Between Bone and Other Tissues: Brain-Bone Axis and Bone-Adipo Axis Shu Takeda 267

17 Mechanobiology of Bone Development and Computational Simulations Gongfa Chen Michael Schuetz Mark Pearcy 279

Subject Index 297

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