Bone and Osteoarthritis / Edition 1

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Bone and Osteoarthritis places emphasis on the molecular and cellular events that lead to osteoarthritis, stressing the role of subchondral bone, which distinguishes this from other books on the disease. A novel aspect is the attention given to the possible epigenetic basis, together with a discussion of the genetics predisposing to osteoarthritis. Detailed analyses are given of the role of the synovium, of the molecular mechanisms that lead to degradation of the cartilage matrix, of the hypertrophy of the cartilage cell, of the anabolic and catabolic roles of cytokines, may lead to novel approaches to clinical treatment, utilizing anabolic mediators or molecules that target steps in the disease process. Also discussed are animal models and how mechano-responsiveness is compromised by mechanical injury. Orthopedics and rheumatology have become close conceptually, as advances in bone and joint biology have enabled bench and translational scientists, as well as practitioners, to approach clinical problems comprehensively. Because bone plays a role in initiating osteoarthritis, therapeutic approaches focusing on bone tissue are included in the discussion of novel treatments. The general topic of osteoarthritis is therefore a timely subject for a series on bone biology.

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Product Details

  • ISBN-13: 9781846285134
  • Publisher: Springer London
  • Publication date: 11/28/2007
  • Series: Topics in Bone Biology Series, #4
  • Edition description: 2007
  • Edition number: 1
  • Pages: 218
  • Product dimensions: 7.10 (w) x 10.00 (h) x 0.70 (d)

Meet the Author

Series Editors of Topics in Bone Biology are: Professors Felix Bronner, PhD - University of Connecticut Health Center, Farmington, CT, USA, and Dr Mary C. Farach-Carson, PhD - the Department of Biology, University of Delaware, Newark, DE, USA. In this fourth volume, the Series Editors are joined by a co-editor with special expertise in the volume topic, Dr Richard F. Loeser, MD, the Robert S. Katz, MD - Joan and Paul Rubschlager Presidential Professor of Osteoarthritis Research in the Department of Internal Medicine, Section of Rheumatology with a conjoint appointment in the Department of Biochemistry, Rush University, Chicago, IL, USA.

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Table of Contents

Preface     v
Contributors     xi
The Pathogenesis of Osteoarthritis   Helmtrud I. Roach   Simon Tilley     1
The Role of Bone in the Development of Osteoarthritis   Daniel Lajeunesse   Pascal Reboul     19
Cytokines, Growth Factors, and Bone-Derived Factors in Cartilage   Mary B. Goldring     41
The Synovium and Its Role in Osteoarthritis   Arjen B. Blom   Wim B. van den Berg     65
Cartilage Matrix Destruction   Dick Heinegard     81
Anabolic Mediators of Cartilage Healing   Naoshi Fukui   Linda J. Sandell     97
Chondrocyte Hypertrophy and Apoptosis at the Cartilage-Bone Interface   Irving M. Shapiro   Christopher S. Adams   Vickram Srinivas   Theresa A. Freeman     109
Genetic and Epigenetic Aspects of Osteoarthritis   Kay E. Chapman   Helmtrud I. Roach     131
Animal Models   Alison M. Bendele     149
Biomechanical Aspects: Joint Injury and Osteoarthritis   Diana H. Chai   Anna L. Stevens   Alan J. Grodzinsky     165
Novel Osteoarthritis Therapeutics   Clifton O. Bingham, III     181
Index     199
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