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Bound Carbohydrates in Nature

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Overview

Based on a series of six lectures delivered at the University of Siena and reflecting the author's career in biochemical research, this text considers the role that bound carbohydrates play in nature, the properties of membrane glycoproteins and the metabolism of sugars and sialic acids.
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Product Details

  • ISBN-13: 9780521442312
  • Publisher: Cambridge University Press
  • Publication date: 4/28/2012
  • Series: Lezioni Lincee Series
  • Pages: 126
  • Product dimensions: 5.43 (w) x 8.50 (h) x 0.43 (d)

Table of Contents

Preface
1 The carbohydrates of glycoproteins 1
History 3
Microheterogeneity of bound carbohydrates 6
Function of bound carbohydrates 8
Inducible changes in bound carbohydrates 13
Programmed changes in bound carbohydrates 17
A possible role for bound carbohydrates 19
2 Derivatives of neuraminic acid 23
Sialic acids 23
Distribution of sialic acids in nature 25
The state of sialic acids in nature 27
The metabolism of hexosamines and sialic acids 28
Metabolic control of hexosamines and sialic acids 37
Asparagine N-glycosylation 41
Processing of lysosomal enzymes 49
Biosynthesis of O-linked oligosaccharides 50
Modification of sialic acids 52
Sialidases (neuraminidases) 53
Genetic metabolic disorders involving sialic acids 57
Glycosidases 58
Bound carbohydrates in malignancy 61
3 Multidrug resistance 71
Properties of P-glycoprotein 72
Lysosomes and multidrug resistance 75
Kinetics of influx and efflux of drugs 79
Modulation of multidrug resistance 84
The role of lipids in the accumulation of drugs by MDR cells 86
P-170 and membrane lipids 93
References 102
Index 110
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