Bound Carbohydrates in Nature

Bound Carbohydrates in Nature

by Leonard Warren, Warren Leonard
     
 

ISBN-10: 0521447437

ISBN-13: 9780521447430

Pub. Date: 03/28/2008

Publisher: Cambridge University Press

Based on a series of six lectures delivered at the University of Siena and reflecting the author's career in biochemical research, this text considers the role that bound carbohydrates play in nature, the properties of membrane glycoproteins and the metabolism of sugars and sialic acids.  See more details below

Overview

Based on a series of six lectures delivered at the University of Siena and reflecting the author's career in biochemical research, this text considers the role that bound carbohydrates play in nature, the properties of membrane glycoproteins and the metabolism of sugars and sialic acids.

Product Details

ISBN-13:
9780521447430
Publisher:
Cambridge University Press
Publication date:
03/28/2008
Series:
Lezioni Lincee Series
Edition description:
New Edition
Pages:
128
Product dimensions:
5.43(w) x 8.50(h) x 0.31(d)

Table of Contents

Preface
1The carbohydrates of glycoproteins1
History3
Microheterogeneity of bound carbohydrates6
Function of bound carbohydrates8
Inducible changes in bound carbohydrates13
Programmed changes in bound carbohydrates17
A possible role for bound carbohydrates19
2Derivatives of neuraminic acid23
Sialic acids23
Distribution of sialic acids in nature25
The state of sialic acids in nature27
The metabolism of hexosamines and sialic acids28
Metabolic control of hexosamines and sialic acids37
Asparagine N-glycosylation41
Processing of lysosomal enzymes49
Biosynthesis of O-linked oligosaccharides50
Modification of sialic acids52
Sialidases (neuraminidases)53
Genetic metabolic disorders involving sialic acids57
Glycosidases58
Bound carbohydrates in malignancy61
3Multidrug resistance71
Properties of P-glycoprotein72
Lysosomes and multidrug resistance75
Kinetics of influx and efflux of drugs79
Modulation of multidrug resistance84
The role of lipids in the accumulation of drugs by MDR cells86
P-170 and membrane lipids93
References102
Index110

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