Bound Carbohydrates in Natureby Leonard Warren, Warren Leonard
Pub. Date: 03/28/2008
Publisher: Cambridge University Press
Based on a series of six lectures delivered at the University of Siena and reflecting the author's career in biochemical research, this text considers the role that bound carbohydrates play in nature, the properties of membrane glycoproteins and the metabolism of sugars and sialic acids.
Table of Contents1. Introduction, history, microheterogeneity of bound carbohydrates; function of bound carbohydrates; inducible changes in bound carbohydrates; programmed changes in bound carbohydrates; a possible role for bound carbohydrates; 2. Sialic acids; distribution of sialic acids in nature; the metabolism of hexamines and sialic acids; metabolic control of hexosamines and sialic acids; asparagine N-glycosylation; processing of lysomal enzymes; biosynthesis of O-linked oligosaccarides; modification of sialic acids; sialidases; genetic metabolic disorders involving sialic acids, glycosidases, bound carbohydrates in malignancy; 3. Multidrug resistance, properties of P-glycoprotein; lysomes and multidrug resistance; kinetics of influx and efflux of drugs, modulation of multidrug resistance; the role of lipids in the accumulation of drugs by MDR cells; P-170 and membrane lipids; Overview.
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