The Brain Immune Axis and Substance Abuse

Overview

'Very interesting book for researchers and practitioner's in the fields of neuroscience, immunology, and substance abuse....presents new and unpublished data...reflects the need for further study into the brain immune axis.' -Doody's Journal

The book contains black-and-white illustrations.

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Paperback (Softcover reprint of the original 1st ed. 1995)
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Overview

'Very interesting book for researchers and practitioner's in the fields of neuroscience, immunology, and substance abuse....presents new and unpublished data...reflects the need for further study into the brain immune axis.' -Doody's Journal

The book contains black-and-white illustrations.

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Editorial Reviews

Lori R. Solaro
This book compiles 31 lectures presented during the second annual symposium on the Brain Immune Axis and Substance Abuse held in June of 1994. The purpose is to inspire interest in the study of the effect of drugs of abuse on the brain immune axis by presenting new data on molecular and cellular immunomodulation of drugs of abuse (particularly opiates and cannabanoids), by describing consequences of immunomodulation on the pathogenesis of diseases, and by addressing effects of the immune system on the nervous system. This is a relatively recent field of research that deserves further investigation. Targeted especially for neuroscientists, this book will be interesting for immunologists, pharmacologists, microbiologists, and healthcare professionals caring for individuals with addictive and infectious disorders. The authors of the articles are credible researchers. The book includes numerous graphs, tables, and figures to illustrate research results. Chapter references are extensive and current. This is a very interesting book for researchers and practitioners in the fields of neuroscience, immunology, and substance abuse. It presents new and unpublished data from investigations into a recent area of research, the effects of substance abuse (particularly abuse of opiates and cannabanoids) on immunity, and the effects of immunomodulation by drugs of abuse of the nervous system. Also addressed using animal models are the interactions between drug exposure, immune dysfunction and infectious disease. This book reflects the need for further study into the brain immune axis.
From The Critics
Reviewer: Lori R. Solaro, MD (Rush University Medical Center)
Description: This book compiles 31 lectures presented during the second annual symposium on the Brain Immune Axis and Substance Abuse held in June of 1994.
Purpose: The purpose is to inspire interest in the study of the effect of drugs of abuse on the brain immune axis by presenting new data on molecular and cellular immunomodulation of drugs of abuse (particularly opiates and cannabanoids) , by describing consequences of immunomodulation on the pathogenesis of diseases, and by addressing effects of the immune system on the nervous system. This is a relatively recent field of research that deserves further investigation.
Audience: Targeted especially for neuroscientists, this book will be interesting for immunologists, pharmacologists, microbiologists, and healthcare professionals caring for individuals with addictive and infectious disorders. The authors of the articles are credible researchers.
Features: The book includes numerous graphs, tables, and figures to illustrate research results. Chapter references are extensive and current.
Assessment: This is a very interesting book for researchers and practitioners in the fields of neuroscience, immunology, and substance abuse. It presents new and unpublished data from investigations into a recent area of research, the effects of substance abuse (particularly abuse of opiates and cannabanoids) on immunity, and the effects of immunomodulation by drugs of abuse of the nervous system. Also addressed using animal models are the interactions between drug exposure, immune dysfunction and infectious disease. This book reflects the need for further study into the brain immune axis.
Booknews
Proceedings from the second annual symposium on the above- titled topic held in June 1994 in Palm Beach, Florida Papers address the direct effects of drugs of abuse on various components of the immune system, as well as those mediated indirectly by the central nervous system and the neuroendocrine system. Some topics covered in the volume's 31 papers include the cellular basis for opioid-induced immunosuppression; marijuana, receptors and immunomodulation; and HIV-1 heterogeneity and cytokines. Annotation c. Book News, Inc., Portland, OR (booknews.com)

4 Stars! from Doody
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Product Details

  • ISBN-13: 9781461358015
  • Publisher: Springer US
  • Publication date: 4/30/2013
  • Series: Advances in Experimental Medicine and Biology Series , #373
  • Edition description: Softcover reprint of the original 1st ed. 1995
  • Edition number: 1
  • Pages: 245
  • Product dimensions: 6.69 (w) x 9.61 (h) x 0.55 (d)

Table of Contents

1. Introduction: The Brain-Immune Axis: Role of Opiates and Other Substances of Abuse, the Hypothalmic-Pituitary-Adrenal Axis and Behavior.- 2. Detection of—-Opioid Receptor mRNA in Immature T Cells.- 3. Identification of Opioid Receptors in the Immune System Using a Novel Combination of Selective Opioid Ligands and Indirect Phycoerythrin Immunofluorescence.- 4. Kappa Opioid Receptors on Three Related Thymoma Cell Lines: Differences in Receptor-Effector Coupling.- 5. Delta Opioid Agonists Inhibit Proliferation of Highly Purified Murine CD4+ and CD8+ T-Cells.- 6. Mitogenic Activation of Human T Lymphocytes Induces a High Affinity Morphine Binding Site.- 7. Morphine-Induced Suppression of Thymocyte Proliferation Is Mediated by Inhibition of I1-2 Synthesis.- 8. Active—-Endorphin Metabolites Generated by T-Cell Ectopeptidases.- 9. The Cellular Basis for Opioid-Induced Immunosuppression.- 10. Endogenous Opioid Peptides Suppress Cytokine-Mediated Upregulation of HIV-1 Expression in the Chronically Infected Promonocyte Clone U1.- 11. Relevance of Opioid Bimodality to Tolerance/Dependence Formation: From Transmitter Release to Second Messenger Formation.- 12. Agonist Induced Constitutive Receptor Activation As a Novel Regulatory Mechanism:— Receptor Regulation.- 13. Expression of Cannabinoid Receptor mRNA in Murine and Human Leukocytes.- 14. Cannabinoid Stimulation of Arachidonate Metabolism in Human Peripheral Blood Mononuclear Leukocytes.- 15. Marijuana, Receptors and Immunomodulation.- 16. Mouse Strain Differences in in vivo and in vitro Immunosuppressive Effects of Opioids.- 17. The Clastogenicity of Morphine Sulfate in vivo.- 18. Cellular Mechanisms Involved in Morphine-Mediated Suppression of CTL Activity.- 19. Evidence for the Involvement of Macrophage-Derived Nitric Oxide in the Immunomodulatory Effect of Morphine and Aversive Pavlovian Conditioning.- 20. Mechanisms Whereby Macrophage-Derived Nitric Oxide Is Involved in the Immunomodulatory Effects of Morphine.- 21. Effects of Central Administration of Morphine on Immune Status in Lewis and Wistar Rats.- 22. Morphine Alteration of Histamine Release in vivo.- 23. Effect of Chronic Morphine Treatment on Immune Responses to Keyhole Limpet Hemocyanin in Swine.- 24. SIV Mutations Detected in Morphine-Treated Macaca mulatta Following SIVmac239 Infection.- 25. Adjuvant Effects on Morphine-Induced Suppression of Immune Responses to MN rgp120/HIV-1 in Mice.- 26. Possible Mechanisms of Immunotoxicity Following in vivo Exposure to the Inhalant, Isobutyl Nitrite.- 27. Role of Immune Processes in Peripheral Opioid Analgesia.- 28. Chronic Treatment with Morphine and Ethanol, but Not Cocaine, Attenuates I1-1? Activation of FOS Expression in the Rat Hypothalamic Paraventricular Nucleus.- 29. Effects of r-Hu-Interferon-?2A in the Brain.- 30. Quantification of Macrophage-Derived Substance P Receptor mRNA Using Competitive Polymerase Chain Reaction.- 31. HIV-1 Heterogeneity and Cytokines: Neuropathogenesis.

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