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Doody's Review ServiceReviewer: Ramsis Farid Ghaly, MD, FACS (Ghaly Neurosurgical Associates)
Description: The book presents the newest updates and the major turning points in the management of central nervous system tumors, both common and rare. As a textbook and reference in brain oncology, it remains an authority in the area, with updates of the significant contributions to the further understanding of the timely diagnosis and treatment of brain tumors. Chapters touch on a wide variety of topics, advances, basic principles of CNS tumors in general, and specific tumors including gliomas, neuronal and neuronal precursor tumors, pituitary tumors, skull base tumors, cerebral lymphoma, tumor-like malformations, and metastatic brain tumors. This new edition involves new authors and includes new chapters on such topics as molecular neuropathology, the role of cancer stem cells, new models of brain tumors, and changes in tumor classification.
Purpose: The purpose is to provide a timely reference and encyclopedic approach to the diagnosis and treatment of CNS tumors.
Audience: All adult and pediatric neurosurgeons, neurologists, neuroradiologists, geneticists, epidemiologists, family practitioners, and primary care physicians are among the intended audience. Both editors are internationally known neurosurgeons.
Features: The book is divided into two sections covering basic principles and specific brain tumors. The first section presents a historical perspective before covering stem cell and progenitor cell lineages as targets for neoplastic transformation in the central nervous system, the classification and pathogenesis of brain tumors, the epidemiology of brain tumors, neurogenetics and the molecular biology of human brain tumors, biological therapy for malignant gliomas, gene therapy for human brain tumors, immunology of brain tumors and implications for immunotherapy, histopathology, advanced imaging, neuro-ophthalmology, epilepsy associated with brain tumors, anesthesia and intensive care management of these patients, surgical principles in the management of brain tumors, the role of radiosurgery and radiotherapy, clinical trials and chemotherapy, mouse models for brain tumor therapy, and management of brain tumors in the pediatric patient. The first of the 10 parts in the second section covers management of recurrent gliomas and meningiomas, low-grade astrocytomas, glioblastomas and malignant astrocytomas, oligodendroglioma, brainstem tumors, intracranial ependymomas, choroid plexus tumors and uncommon glial tumors. Part 2 is devoted to neuronal and neuronal precursor tumors, medulloblastoma, and primitive neuroectodermal tumors, while part 3 covers nerve sheath tumors, acoustic neurinoma (vestibular schwannoma), other schwannomas of cranial nerves, and brain tumors associated with neurofibromatosis. Part 4 covers meningeal tumors, meningiomas, meningeal hemangiopericytomas, and meningeal sarcomas. Part 5 describes pineal region tumors, pineal cell, and germ cell tumors, while part 6 covers nonfunctional pituitary tumors and diagnostic considerations and surgical results for hyperfunctioning pituitary adenomas. Part 7 covers skull base tumors, chordomas and chondrosarcomas of the skull base, glomus jugulare tumors, carcinoma of the paranasal sinuses and esthesioneuroblastoma. Part 8 covers cerebral lymphoma and primary central nervous system lymphoma. Part 9 covers tumor-like malformations, craniopharyngiomas, dermoid, epidermoid, and neurenteric cysts, and colloid cysts. Finally, part 10 covers metastatic brain tumors.
Assessment: This area has been exploding with new innovation and understanding, especially in tumor biology and etiology and treatment strategies. This edition highlights the updates in the diagnosis and management of brain tumors, using excellent illustrations and clear and coherent descriptions. For each tumor, the book provides an introduction and discusses the epidemiology, clinical presentation, imaging features, anatomy and pathology (macroscopic appearance, histopathological diagnosis and grading, microscopic appearance, histological grading), differential diagnosis, treatment (general principles, surgery, radiotherapy, chemotherapy), prognosis, concluding with key points and well-recognized updated references.