Brain Tumors: An Encyclopedic Approach, Expert Consult - Online and Print / Edition 3

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Meet the increasing need for effective brain tumor management with the highly anticipated revision of Brain Tumors by Drs. Andrew H. Kaye and Edward R. Laws. Over the past decade, enormous advances have been made in both the diagnosis and the surgical and radiotherapeutic management of brain tumors. This new edition guides you through the latest developments in the field, including hot topics like malignant gliomas, functional brain mapping, neurogenetics and the molecular biology of brain tumors, and biologic and gene therapy. You’ll also have easy access to the complete contents online, with links to PubMed and a downloadable image library, at

• Benefit from the knowledge and experience of Drs. Andrew H. Kaye and Edward R. Laws, globally recognized experts in the field of neurosurgery, as well as many other world authorities.

• Access the complete searchable contents online at, with links to PubMed and a downloadable image library.
• Stay up to date with the latest developments in the field, including management of

malignant gliomas; functional brain mapping; neurogenetics and the molecular biology of brain tumors; biologic and gene therapies; and much more.

Apply the expert’s best practices with their key points .

The expert guidance of Drs. Kaye and Laws allows you to effectively deal with the increasing incidence of brain tumors, from diagnosis to surgical and radiotherapeutic management.

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Editorial Reviews

Doody's Review Service
Reviewer: Ramsis Farid Ghaly, MD, FACS (Ghaly Neurosurgical Associates)
Description: The book presents the newest updates and the major turning points in the management of central nervous system tumors, both common and rare. As a textbook and reference in brain oncology, it remains an authority in the area, with updates of the significant contributions to the further understanding of the timely diagnosis and treatment of brain tumors. Chapters touch on a wide variety of topics, advances, basic principles of CNS tumors in general, and specific tumors including gliomas, neuronal and neuronal precursor tumors, pituitary tumors, skull base tumors, cerebral lymphoma, tumor-like malformations, and metastatic brain tumors. This new edition involves new authors and includes new chapters on such topics as molecular neuropathology, the role of cancer stem cells, new models of brain tumors, and changes in tumor classification.
Purpose: The purpose is to provide a timely reference and encyclopedic approach to the diagnosis and treatment of CNS tumors.
Audience: All adult and pediatric neurosurgeons, neurologists, neuroradiologists, geneticists, epidemiologists, family practitioners, and primary care physicians are among the intended audience. Both editors are internationally known neurosurgeons.
Features: The book is divided into two sections covering basic principles and specific brain tumors. The first section presents a historical perspective before covering stem cell and progenitor cell lineages as targets for neoplastic transformation in the central nervous system, the classification and pathogenesis of brain tumors, the epidemiology of brain tumors, neurogenetics and the molecular biology of human brain tumors, biological therapy for malignant gliomas, gene therapy for human brain tumors, immunology of brain tumors and implications for immunotherapy, histopathology, advanced imaging, neuro-ophthalmology, epilepsy associated with brain tumors, anesthesia and intensive care management of these patients, surgical principles in the management of brain tumors, the role of radiosurgery and radiotherapy, clinical trials and chemotherapy, mouse models for brain tumor therapy, and management of brain tumors in the pediatric patient. The first of the 10 parts in the second section covers management of recurrent gliomas and meningiomas, low-grade astrocytomas, glioblastomas and malignant astrocytomas, oligodendroglioma, brainstem tumors, intracranial ependymomas, choroid plexus tumors and uncommon glial tumors. Part 2 is devoted to neuronal and neuronal precursor tumors, medulloblastoma, and primitive neuroectodermal tumors, while part 3 covers nerve sheath tumors, acoustic neurinoma (vestibular schwannoma), other schwannomas of cranial nerves, and brain tumors associated with neurofibromatosis. Part 4 covers meningeal tumors, meningiomas, meningeal hemangiopericytomas, and meningeal sarcomas. Part 5 describes pineal region tumors, pineal cell, and germ cell tumors, while part 6 covers nonfunctional pituitary tumors and diagnostic considerations and surgical results for hyperfunctioning pituitary adenomas. Part 7 covers skull base tumors, chordomas and chondrosarcomas of the skull base, glomus jugulare tumors, carcinoma of the paranasal sinuses and esthesioneuroblastoma. Part 8 covers cerebral lymphoma and primary central nervous system lymphoma. Part 9 covers tumor-like malformations, craniopharyngiomas, dermoid, epidermoid, and neurenteric cysts, and colloid cysts. Finally, part 10 covers metastatic brain tumors.
Assessment: This area has been exploding with new innovation and understanding, especially in tumor biology and etiology and treatment strategies. This edition highlights the updates in the diagnosis and management of brain tumors, using excellent illustrations and clear and coherent descriptions. For each tumor, the book provides an introduction and discusses the epidemiology, clinical presentation, imaging features, anatomy and pathology (macroscopic appearance, histopathological diagnosis and grading, microscopic appearance, histological grading), differential diagnosis, treatment (general principles, surgery, radiotherapy, chemotherapy), prognosis, concluding with key points and well-recognized updated references.
From the Publisher
"The book will be indispensable for anyone involved in the study of brain tumors, especially for neuropathologists, neurologists, neurosurgeons, endocrinologists, and radiologists. The editors have gathered well-known experts to author each of the 63 chapters, providing the reader with a comprehensive selection of important issues on all aspects of brain tumors and ensuring that this book will become a classic source of multidisciplinary information….The book is particularly useful as a first source of integrated information for the everyday practice of neuro-oncology." - New England Journal of Medicine, review of the previous edition

"The previous edition was not only updated, but many new chapters along with new authors have been included, all reflecting the continuous change in concepts, technologies, and outcomes in highly recommended not only to neurosurgeons, neurologists, neuroscientists but also to all engaged in neurooncology as a standard reference work about all aspects of brain tumors."

European Journal of Neurology 2012

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Product Details

  • ISBN-13: 9780443069673
  • Publisher: Elsevier Health Sciences
  • Publication date: 12/20/2011
  • Edition number: 3
  • Pages: 1088
  • Sales rank: 1,424,771
  • Product dimensions: 8.90 (w) x 11.10 (h) x 1.70 (d)

Table of Contents

1 Historical perspective 1

2 Stem cells and progenitor cell lineages in the central nervous system 6

3 Classification and pathogenesis of brain tumors 36

4 Epidemiology of brain tumors 59

5 Neurogenetics and the molecular biology of human brain tumors 83

6 Biologic therapy for malignant glioma 102

7 Gene therapy for human brain tumors 114

8 Immunology of brain tumors and implications for immunotherapy 125

9 Histopathology of brain tumors 138

10 Advanced imaging of brain tumors 188

11 Neuro-ophthalmology of brain tumors 214

12 Epilepsy associated with brain tumors 237

13 Anesthesia and intensive care management of patients with brain tumors 249

14 Surgical principles in the management of brain tumors 282

15 Radiosurgery and radiotherapy for brain tumors 296

16 Clinical trials and chemotherapy 306

17 Mouse models for brain tumor therapy 316

18 Management of brain tumors in the pediatric patient 329

19 Management of recurrent gliomas and meningiomas 347

20 Low-grade astrocytomas 372

21 Glioblastoma and malignant astrocytoma 384

22 Oligodendroglioma 408

23 Brainstem tumors 424

24 Intracranial ependymomas 435

25 Choroid plexus tumors 450

26 Uncommon glial tumors 462

27 Medulloblastoma and primitive neuroectodermal tumors 503

28 Acoustic neurinoma (vestibular schwannoma) 518

29 Other schwannomas of cranial nerves 570

30 Brain tumors associated with neurofibromatosis 588

31 Meningiomas 600

32 Meningeal hemangiopericytomas 630

33 Meningeal sarcomas 638

34 Pineal cell and germ cell tumors 646

35 Non-functional pituitary tumors 672

36 Diagnostic considerations and surgical results for hyperfunctioning pituitary adenomas 692

37 Chordomas and chondrosarcomas of the skull base 723

38 Glomus jugulare tumors 743

39 Carcinoma of the paranasal sinuses 750

40 Esthesioneuroblastoma: management and outcome 767

41 Primary central nervous system lymphoma 779

42 Craniopharyngiomas 807

43 Dermoid, epidermoid, and neurenteric cysts 831

44 Colloid cysts 849

45 Metastatic brain tumors 864

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