Breast Cancer: Molecular Genetics, Pathogenesis, and Therapeutics / Edition 1

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Overview

A comprehensive state-of-the-art summary of breast cancer research and treatment by leading authorities. The book's many distinguished contributors illuminate the biology and genetics of breast cancer, including what is known about the hereditary breast cancer genes, BRCA1 and 2, the cutting-edge cytogenic approaches, and the biology of breast cancer metastasis. In addition, the authors describe current and future methods of breast cancer treatment in depth, and discuss environment and diet as risk factors for the disease. Breast Cancer: Molecular Genetics, Pathogenesis, and Therapeutics constitutes an excellent reference and resource for all those clinical and experimental oncologists, as well as genetic counselors nurses, who need to understand the latest developments in breast cancer biology, risk, and treatment.

The book contains predominantly black-and-white illustrations, with some color illustrations.

This book provides a comprehensive review of current breast cancer research and treatment. It provides a comprehensive background on the genetic changes associated with breast cancer and an up-to-date description of the genetics and biology of hereditary breast cancer genes, BRCA1 and 2. State-of-the-art cytogenetic approaches to breast cancer are also described as well as the biology of tumor progression. By obtaining an overall picture of the biology and genetics of breast cancer, as well as knowledge of the agents that contribute to increased breast cancer risk, scientists will broaden their knowledge of this disease, permitting them to focus on the critical questions that must be addressed in breast cancer research today.

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Editorial Reviews

Doody's Review Service
Reviewer: Jacqueline S. Jeruss, MD (Northwestern Memorial Hospital)
Description: This book provides a relatively detailed review of the current thinking regarding basic breast cancer research and its therapeutic applications.
Purpose: The purpose is to provide an overview of some of the most recent advances in the understanding of breast cancer genetics, pathogenesis, and therapeutics.
Audience: It is geared toward graduate students and scientists involved in breast cancer research, and physicians specializing in the care of breast cancer patients.
Features: Extensive information about a multitude of topics associated with breast cancer genetics and possible causative factors in breast cancer progression is provided. This book also includes both a generalized overview of breast cancer therapeutics as well as the most current thoughts on experimental treatment ideas. The chapter, "Hereditary Breast Cancer Genes," is extremely well covered, especially the discussion of BRCA 1 and BRCA 2 mutations in the Ashkenazi population. The chapter on psychological issues surrounding genetic testing is particularly strong because of its use of case examples. The discussion of surgical and chemotherapeutic approaches is thorough and cohesive, as is the chapter on drug resistance and the implications of the MDR gene.
Assessment: This book could have had less repetition, which is a direct result of its multiple contributors. Additionally, stronger introductory chapters would have provided better organization and flow of the book's content. On a whole, this is an excellent resource for researchers in the field. Texts such as Lynch's Genetics and Breast Cancer (Van Nostrand Reinhold,1980) and Lippman's Genes, Oncogenes, and Hormones: Advance in Cellular and Molecular Biology of Breast Cancer (Kluwer Academic Publishers, 1992) are key to providing background on breast cancer genetics and basic science. This book stands out in that it provides a comprehensive approach to the relevant advances in breast cancer research as they apply to therapeutics, an approach that has been missing in the recent literature.
Jacqueline S. Jeruss
This book provides a relatively detailed review of the current thinking regarding basic breast cancer research and its therapeutic applications. The purpose is to provide an overview of some of the most recent advances in the understanding of breast cancer genetics, pathogenesis, and therapeutics. It is geared toward graduate students and scientists involved in breast cancer research, and physicians specializing in the care of breast cancer patients. Extensive information about a multitude of topics associated with breast cancer genetics and possible causative factors in breast cancer progression is provided. This book also includes both a generalized overview of breast cancer therapeutics as well as the most current thoughts on experimental treatment ideas. The chapter, "Hereditary Breast Cancer Genes," is extremely well covered, especially the discussion of BRCA 1 and BRCA 2 mutations in the Ashkenazi population. The chapter on psychological issues surrounding genetic testing is particularly strong because of its use of case examples. The discussion of surgical and chemotherapeutic approaches is thorough and cohesive, as is the chapter on drug resistance and the implications of the MDR gene. This book could have had less repetition, which is a direct result of its multiple contributors. Additionally, stronger introductory chapters would have provided better organization and flow of the book's content. On a whole, this is an excellent resource for researchers in the field. Texts such as Lynch's Genetics and Breast Cancer (Van Nostrand Reinhold,1980) and Lippman's Genes, Oncogenes, and Hormones: Advance in Cellular and Molecular Biology ofBreast Cancer (Kluwer Academic Publishers, 1992) are key to providing background on breast cancer genetics and basic science. This book stands out in that it provides a comprehensive approach to the relevant advances in breast cancer research as they apply to therapeutics, an approach that has been missing in the recent literature.
Booknews
A broad reference for clinical or experimental oncologists, genetic counselors, nurses, and others who need detailed knowledge about breast cancer. Specialists working in the field analyze the molecular lesions associated with sporadic and hereditary breast cancer, detail the disease's progression and the mechanisms for invasion and metastasis, review the role of smoking and high-fat diets, discuss naturally occurring and synthetic compounds that mimic estrogen, and survey the psychosocial issues related to testing. They also present what is known so far about the heredity breast-cancer genes BRCA1 and 2 and cytogenic approaches. Annotation c. by Book News, Inc., Portland, Or.

3 Stars from Doody
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Product Details

  • ISBN-13: 9780896035607
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 1/28/1999
  • Series: Contemporary Cancer Research Series
  • Edition description: 1999
  • Edition number: 1
  • Pages: 582
  • Product dimensions: 7.36 (w) x 10.33 (h) x 1.33 (d)

Table of Contents

Preface
List of Contributors
I Etiology: Genetic Changes Associated with Breast Cancer
1 The Estrogen Receptor and Breast Cancer 1
2 Epidermal Growth Factor-Related Peptides and Their Cognate Receptors in Breast Cancer 31
3 The Role of Fibroblast Growth Factors in Breast Cancer Pathogenesis and Progression 59
4 Transforming Growth Factor-[beta] and Breast Cancer 95
5 The Insulin-Like Growth Factor Network and Breast Cancer 121
6 Molecular Alterations in Breast Cancer 143
7 Apoptosis and the Development of Breast Cancer 171
8 WNT Genes and Breast Cancer 181
9 Hereditary Breast Cancer Genes 199
10 Biological Functions of the BRCA1 and BRCA2 Proteins 225
11 Psychosocial Issues in BRCA1/2 Testing 247
II Biology of Tumor Progression: Breast Cancer Metastasis
12 Nm23, Breast Differentiation, and Cancer Metastasis 267
13 Role of Integrins in the Development and Malignancy of the Breast 285
14 Matrix Metalloproteinases in the Pathogenesis of Breast Cancer 305
15 The Urokinase Plasminogen Activation System in Breast Cancer 325
16 Angiogenesis in Breast Cancer: Role in Biology, Tumor Progression, and Prognosis 347
III Therapeutics and Diagnostics: Diagnosis
17 Cytogenetic Approaches to Breast Cancer 373
18 Current and Future Directions in Surgical and Chemotherapeutic Approaches to Breast Cancer Treatment 389
19 Breast Cancer Therapy Using Monoclonal Antibodies Against Epidermal Growth Factor Receptor and HER-2 419
20 Towards the Therapeutic Targeting of Matrix Metalloproteinases in Breast Cancer 437
21 MUC1 Mucin as a Tumor Antigen in Breast Cancer 453
22 Aromatase Inhibitors and the Role of Hormonal Therapy in Breast Cancer 469
23 Drug Resistance in Breast Cancer 481
24 Smoking as a Risk Factor for Breast Cancer 519
25 The Estrogenicity of Selected Nutrients, Phytochemicals, Pesticides, and Pollutants: Their Potential Roles in Breast Cancer 537
Index 569
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