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Doody's Review ServiceReviewer: Jon Webb, MD (University of Kentucky College of Medicine)
Description: This eighth edition of a classic textbook in nephrology provides a comprehensive review of the pathogenesis, pathophysiology, and clinical decisions regarding the kidney.
Purpose: The goal is to provide a reference on the physiology of the kidney with a focus on the development of pathology and subsequent clinical management. In its attempt to focus on modern literature, the book is shorter than previous versions. This edition stresses the importance of incorporating new information. First, 40 percent of the contributors are new to this edition and, second, the authors were encouraged to focus on literature published after 1990. Lastly, an e-dition is incorporated, providing electronic access to chapters, tables, and relevant journal articles.
Audience: This is an excellent tool for nephrologists, both clinical and research oriented. The masterful organization and colorful display will also attract medical students, internists, pediatricians, and urologists, providing an easily accessible resource for specific topics on kidney disease.
Features: This edition is newly organized in 12 sections that cover normal renal function (nine chapters on embryology, anatomy, and physiology of tubule functions); integrated control of body fluid volume and composition (seven chapters on molecules that influence renal function followed by a review of electrolyte disorders); epidemiology and risk factors in kidney disease (a new section of five chapters focusing on aging, gender, and other factors that affect renal disease risk); pathogenesis of renal disease (seven chapters describe the diagnostic assessment of kidney disease and include an extensive imaging library); disorders of kidney function (authors with expertise in their respective areas contribute 10 chapters on known major clinical entities); genetic basis of kidney disease (three chapters with an emphasis on cystic diseases and tubule transport disorders); hypertension and the kidney (five chapters on both primary and secondary hypertension, with a breadth of information on antihypertensive drugs and diuretics); the consequences of renal failure (new research findings are a highlight of these six chapters on the systemic ramifications of the uremic state); conservative and pharmacological management of kidney disease (five chapters review the use of common medications in chronic kidney disease and update precautionary measures necessary in advanced disease); invasive therapy of renal failure (five chapters address treatment modalities including hemodialysis, peritoneal dialysis, and plasmapheresis and provide an overview of critical care nephrology); renal transplantation (three chapters review the basic immunology of transplantation and provide a comprehensive discussion of the process of donating and receiving a kidney); frontiers in nephrology (the second new section presents five chapters on the exciting possibilities of the future of managing kidney disease, including xenotransplantation and stem cell utilization). Fourteen new chapters have been added to this edition, including interventional nephrology and endocrine aspects of kidney disease, but the total number of chapters has increased by only four. The dynamic visual improvements provide much enhanced organization over previous editions. In addition, the book features more than 550 color high-quality photographs, an abundance of figures, tables, and algorithms, all accessible thru the electronic e-dition; an image library for presentations; and the constantly evolving electronic version to keep readers informed of the latest trends in management of kidney disease.
Assessment: This is an impressive update from the previous edition, providing a new colorful presentation with a focus on the constantly evolving trends in kidney disease. The sections are well organized, and the chapters are presented in a logical manner. The figures, tables, and images enhance the discussion of each topic. I particularly enjoyed the focus on upcoming trends and potential therapeutic options in the new section on frontiers in nephrology. This remains the gold standard in nephrology textbooks, and I highly recommend it to anyone searching for a resource on kidney disease.