The Business of Healthcare Innovation / Edition 2

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The Business of Healthcare Innovation is the first wide-ranging analysis of business trends in the manufacturing segment of the health care industry, focusing on the key but often neglected role of the "producers" in health systems. Professors of the Wharton School and industry executives provide a detailed overview of the pharmaceutical, biotechnology, genomics/proteomics, medical device and information technology sectors. This book will be essential reading for students and researchers in the field of health management, and of great interest to strategy scholars, industry practitioners, and management consultants.
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Editorial Reviews

From the Publisher
'Burns has produced an exceptional successor to [the first edition of The] Business of Healthcare Innovation with this new edition. The original made an important contribution to those of us who work and invest in the life sciences. The updated and expanded chapters on challenges and possibilities for the pharmaceutical and biotechnology industries, the new insights into the potential of digital health, and the overall theme of convergence of technologies into an innovative model of modern medicine, make [this] a timely and valuable volume.' G. Steven Burrill, CEO, Burrill and Company

'Innovation is the answer to the cost and quality challenges in health care today. Despite its importance, few scholars have offered a comprehensive assessment of innovation in medicine - what it is, how it arises in specific sectors, and what are the barriers to achieving transformation of health care. This ambitious work makes a substantial contribution to our understanding of this key concept in health care.' Kevin A. Schulman, Professor of Medicine and Gregory Mario and Jeremy Mario Professor of Business Administration, Duke University

'Every entrepreneur, no matter whether they be inexperienced or experienced, biotech or device, scientist or business person, needs to read [The] Business of Healthcare Innovation. It is not enough today to have a great idea; successful startups require knowledge of the past, present and future of the … industry if they want a real shot at making a difference.' Mark Levin, Partner and Co-Founder, Third Rock Ventures

'Since the first edition of The Business of Healthcare Innovation, the workings of the industry have become even more complex, intertwined, and tricky to navigate. The industry's evolution is effectively captured in this successor edition which includes important updates relevant to traditional and newer, 'maverick' innovators who will find the insights and frameworks described to be invaluable.' Peter A. Tollman, Senior Partner and Managing Director, The Boston Consulting Group

'For an industry that serves the needs of patients with innovative medicines, there are few scholarly books that analyze the underlying business of the life sciences. The Business of Healthcare Innovation addresses this important need with a thoughtful and engaging analysis of the pharmaceutical and biotechnology sectors. I particularly enjoyed the discussion on biotech, including discussions on the range of business models and on the symbiotic relationship of biotech companies with pharma. If you're interested in the 'business of science', this is really worth a read!' John Maraganore, CEO, Alnylam

'This book is the authoritative text on the medical device industry. The authors combine extensive research with intimate insights to distil a complex topic to its essential ingredients.' Dan Starks, Chairman and CEO, St Jude Medical

'Several significant efforts by government and the private sector are underway to transform health care. These efforts center on diverse performance-based reimbursement mechanisms that bind those who provide care with those who purchase care. As Burns astutely notes, these efforts appear to view those organizations that provide products and services to the industry as incidental to the transformation of care. This view is a mistake. Companies that deliver innovative advances in the life sciences, medical devices and health information technology can be and are significant contributors to our collective efforts to improve care. Vaccines, medical imaging, pacemakers and electronic health records are examples of these contributions. The Business of Healthcare Innovation does an exceptional job of describing the nature, challenges and contributions of the companies that produce these products and services. This understanding is essential …' John Glaser, CEO, Siemens Health Services

'This book does an excellent job of breaking down [a] complicated subject into its unique elements and analyzing each in a clear, direct style that illuminates the key issues facing this rapidly changing industry. The discussion of the sources of, and impediments to, device innovation are particularly welcome. I recommend this astute analysis to healthcare executives, policy-makers, investors, innovators and anyone else who wants to understand the critical importance and future direction of the medical device industry and medical device innovation.' Michael A. Mussallem, Chairman and CEO, Edwards Lifesciences Corporation

'Health care looms as the central issue for the swarm of baby boomers seeking the goal of wellness in this decade. This primer by Robert Burns and his colleagues nicely summarizes the challenges of developing new technologies that will be relevant and affordable. How will health care reform influence the health care industry to innovate and invest in new technologies? What will new regulatory approaches do to early stage investment in new therapies? How will the United States remain a net exporter of medical device and pharmaceuticals that is the envy of the rest of the world? Can uncommon profitability in the device sector be perpetuated? How are the processes of research and development, collaboration, mergers and acquisitions different in the pharmaceutical, biotechnology and medical device industries? The answers can be found in this articulate and well referenced text.' Stephen Oesterle, Senior Vice-President, Medtronic

'Lawton Burns provides an excellent overview of the competitive dynamics of the medical technology sector which has had increasingly [significant] effects on health service costs and outcomes. Understanding the dynamics of this sector is important for all future health care leaders and this comprehensive and accessible book provides first-rate coverage of the subject.' Regina Herzlinger, Harvard Business School

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Product Details

  • ISBN-13: 9781107607774
  • Publisher: Cambridge University Press
  • Publication date: 7/26/2012
  • Edition description: New Edition
  • Edition number: 2
  • Pages: 600
  • Sales rank: 955,742
  • Product dimensions: 6.80 (w) x 9.60 (h) x 1.20 (d)

Meet the Author

Lawton Robert Burns, Ph.D., MBA is the James Joo-Jin Kim Professor, Professor and Chair of Health Care Management and Director of the Center for Health Management and Economics at the Wharton School, University of Pennsylvania.
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Read an Excerpt

Cambridge University Press
0521838983 - The Business of Healthcare Innovation - Edited by Lawton R. Burns


The business of healthcare innovation in the Wharton School curriculum

Lawton R. Burns

Innovation and the value chain in healthcare
The technological imperative in healthcare
The innovation challenge
Why study the producers of healthcare products?
Convergence of technologies across sectors
Impact of technology sectors on local and national economies
Similarities and differences across producer sectors
Overview of the volume and of chapter content

Innovation and the value chain in healthcare

All first-year MBA students at the Wharton School who major in healthcare systems take a required course during their first semester. The course, Healthcare Management 841, analyzes the entire value chain in healthcare (see figure 1.1). The structure of this chain is straightforward: there are three key sets of actors and two sets of intermediaries between them. The three key sets of actors are the individuals and institutions that purchase healthcare, provide healthcare services, and produce healthcare products (purchasers, providers, and producers). Two sets of intermediaries separate these key actors: those firms who finance healthcare (offer insurance to the purchasers and handle reimbursement to the providers) and those who distribute products (from the producers to the providers).

The logic of this chain is a bit more interesting. All of the money that gets pumped into the healthcare system starts on the far left side of figure 1.1 and flows to all of the boxes to the right. Conversely, much of the innovation in healthcare starts on the far right side and flows to the adjacent boxes on the left. The two flows collide in the middle, in the provider side of the industry, that is, doctors and hospitals who then

Image not available in HTML version

Figure 1.1 The US healthcare value chain.

Source: Lawton R. Burns, The Health Care Value Chain (San Francisco, CA: Jossey-Bass, 2002).

have to determine how much of the innovation from the right side they can afford to utilize in patient treatment given the limited supply of funds received from the left side. This is the point at which much of the spending on healthcare and the consumption of healthcare products takes place.

In a prior book, the Wharton faculty examined the flow of money, products, and information between producers, providers, and their intermediaries (wholesalers, distributors, group purchasing organizations).1 The current book examines the producers of the innovative products in the healthcare industry - the major sectors of innovation within the manufacturing side of the industry - on a global basis. These sectors include:

  • Pharmaceutical sector
  • Biotechnology sector
  • Genomics and proteomics sector
  • Medical device sector
  • Information technology sector

The book aims to educate the reader about the structure of each of these industry sectors, the competitive dynamics among firms in these sectors, and the push for technological innovation that distinguishes them from other sectors of healthcare. The book also highlights the growing convergence among these sectors, as innovations in one sector are utilized by another. Chapters contained in this volume are written by faculty, executives, and analysts from these sectors who teach in the Wharton School as part of Healthcare Management 841.

The technological imperative in healthcare

The five industry sectors listed above are responsible for supplying a majority of the innovative products utilized by physicians and hospitals and which are increasingly demanded by consumers. This supply and demand logic has exerted both positive and negative effects.

On the one hand, technology is commonly cited as being the major driver of rising healthcare expenditures worldwide. Scholars have characterized this trend as the "technological imperative" - that is, innovative treatments and equipment are demanded by patients and their (physician) agents on the grounds of quality, and are reimbursed by payers and their fiscal intermediaries. Indeed, empirical evidence from the United States documents that the cost of new technology, and the intensity with which it is used, consistently accounts for anywhere from 20 percent to 40 percent of the rise in health expenditures over the past forty years (see figure 1.2).

Particularly disturbing to many, given these costs, is evidence that high levels of spending on technology, particularly in the US, do not translate into added value and better outcomes on a host of other measures.2 The problem here may be twofold: the overutilization of technology in the US (which increases spending without added benefit) and market-based competition among provider organizations to have the latest equipment (which increases

Image not available in HTML version

Figure 1.2 Technology and intensity of service as share of annual percentage increase in US personal health expenditures, 1961-1998.

Source: Center for Medicare and Medicaid Services (CMS).

the diffusion and utilization of expensive technology at the expense of older, less expensive alternatives).3

Governmental efforts in the US to contain spending on medical technology (e.g., certificate of need laws enacted in the 1970s, the Prospective Payment System enacted in 1983, the threat of presidential-led health reforms in 1978/79 and 1993/94) exerted only short-term effects, followed by a resumption in spending. Governmental restrictions on access to this technology have been a favored method of controlling healthcare costs in other countries.

On the other hand, there is growing public recognition, based on recent scholarly evidence, that such products contribute to increases in longevity and mobility, reductions in disease and pain, improvements in worker productivity, and improvements in quality of life - especially for patients with particular conditions.4 Another recent report argues that increased health spending is "worth it": over the past twenty years, each additional dollar spent on healthcare services in the US produced health gains valued at $2.40-$3.00 (e.g., in terms of increased life expectancy, reduced disability, improved overall health).5 Based on this recognition, there continues to be public pressure for more healthcare spending and access to new technology worldwide.

This book does not seek to attack or defend the technological imperative in healthcare. It takes the position that technology does not increase costs by itself, but rather must be viewed as part of the health systems in which they are used. What is critical are the payment structures and incentives established within a given healthcare system that promote or retard the use of technologies for given patients (and their diffusion to other patients). The book also takes the position that analyses of increased spending on technology must be combined with an analysis of the benefits achieved by using these technological resources.6 Finally, the book takes it as a given that technological innovation will continue to drive the dynamics of the healthcare industry into the future, as it did during the past century.7 The book seeks to analyze the push for innovation through the lenses of the companies that produce it.

The innovation challenge

All of the healthcare sectors studied here are considered "high-technology."8 Like other high-tech industries, innovation is the key driver of competitive advantage and commercial success. Analysts at the Boston Consulting Group (BCG) report that research and development (R&D) investments can account for up to one-third of a medical technology firm's stock price, and are correlated with the firm's gross margins four to five years down the road.9 At the same time, innovation is also the continuing challenge facing firms in these sectors. The high price-to-revenue multiples for many of these firms suggest that financial markets expect these firms to grow revenues and sustain gross margins above and beyond other investment sectors, all of which necessitate continued innovation.10

Successful innovation hinges on many factors, including serendipity of discovery, wise paths taken in the past, wise investment decisions in the present, and access to new technologies via mergers and acquisitions (M&As) and strategic alliances. These factors manifest themselves in terms of favorable market structures, the possession of key resources and capabilities, and fruitful ties with other organizations upstream and downstream in the value chain. However, successful innovation also rests largely on the process skills or the art of management practiced inside of a firm.

This book examines the source of technological innovation in the health-care industry. Specifically, for the firms in each of the innovative sectors listed above we ask the following set of questions:

  • What products do these companies make and what is so innovative about them?
  • What are the different business models of innovation pursued by firms in this sector, and how do they finance them?
  • What are the strategies pursued by firms in this sector?
  • What are the key success factors for innovative firms in this sector?
  • How have firms in these sectors, and the sectors themselves, grown over time?
  • What impact have these firms had on the organization and delivery of healthcare?
  • What are the important competitive and regulatory forces shaping these sectors?

To answer these questions, the book adopts multiple, related perspectives: industrial organization, the resource-based view of the firm, value chain analysis, and organizational innovation and change. These perspectives help to focus on the many determinants of successful innovation. They are outlined below.

Industrial organization perspective

Industrial organization (IO) is a branch of economics that examines the number of competitors in a market (or industry), the size and distribution of these firms and their respective market shares, the degree of concentration (i.e., how many firms account for the majority of the market share), and the strategies pursued to broaden the horizontal and vertical boundaries of the firm (e.g., horizontal consolidation, vertical integration into input and output markets). In the last two decades, the IO perspective has been popularized in Michael Porter's "Five Forces" framework, which analyzes five sets of factors that shape an industry's competitiveness and the ability of firm within it to earn above average profits.11 These forces include: degree of internal rivalry among incumbent firms; threat of entry by new firms; degree of substitution by new products/technologies; bargaining power of suppliers (input side); and bargaining power of buyers (output side). Viewed in this perspective, a firm's competitive advantage derives from the structure of the industry in which it finds itself, as well as its position: for example, small number of large-sized firms, presence of scale economies that serve as an entry barrier, competitive input and output markets, and so on.

The IO perspective is used here to assess the corporate strategies of firms in these sectors. Thus, the chapters discuss the use of M&As to build scale, access new technology and products, and erect barriers to entry; the pursuit of economies of scale and scope to achieve efficiencies; the degree of vertical integration into upstream and downstream markets; and the pursuit of product and market diversification in order to expand.

Resource-based view

The resource-based view (RBV) of the firm suggests that competitive advantage in an industry lies not only in a firm's position within a favorable industry context (i.e., among the five forces above). Advantage also derives from the distinctive capabilities a firm possesses. Capabilities are based on assets and resources that firms harness and coordinate in productive ways. Capabilities become distinctive, strategic, and valuable when a firm can coordinate these resources to provide superior returns in ways that other firms cannot duplicate.12

The RBV perspective is used here to discuss the distinctive abilities of different life sciences firms to create new products. Thus, the next two chapters examine the differential capabilities of large pharmaceutical firms versus smaller biotechnology firms in developing small and large molecules, respectively. The perspective is also used here to analyze the strategic alliances that develop among different life sciences firms to broaden their total set of capabilities. Finally, the RBV perspective is utilized in order to describe the types of integrative processes and learning mechanisms needed to help mergers and acquisitions succeed.

Value chain perspective

The value chain perspective analyzes the entire sequence from raw materials (input) markets to final customer (output) markets.13 The sequence is labeled a "value chain" because each link in the chain adds value to its inputs. Each link also seeks to maximize its contribution to the total product's value added, thereby capturing as much profit as it can. This may involve focusing on only those links that add the greatest value (and let other firms focus on links that add less value), or encompassing as many links as possible in order to maximize the total profit captured (and leave as little as possible for other firms to divide up).

The value chain perspective is used here to assess the business models of firms in these sectors. Thus, the chapters discuss the key steps in the value chain in that sector (e.g., research and development, manufacturing, sales and marketing), how much value is generated within each of those steps, trends in the scope of these activities that firms elect to focus on (e.g., broad versus narrow range of steps), and the use of the strategies above to broaden a firm's business model.

This perspective is also used to assess the trading relationships between adjacent firms in the value chain of healthcare (e.g., producers who supply drugs and devices to providers, payers who reimburse providers for these supplies). A value chain view suggests that firms can develop strategic advantage as they develop long-term, collaborative alliances with adjacent firms that benefit both sides and address problems of information exchange between trading partners.14

Organizational innovation perspective

The organizational innovation perspective draws on management theory and research in order to examine some of the key managerial practices and organizational conditions needed to sustain strategic change. The findings from this literature are so diverse as to warrant a separate volume to summarize them.15 Nevertheless, ingredients for successful innovation include:

  • the need to balance divergent and convergent thinking
  • the need to balance top-down strategic initiatives with bottom-up experimentation
  • the need to balance a focus on short-term efficiency and shareholder value maximization with long-term exploration
  • the ability to source new ideas from anywhere inside and outside the firm
  • the need for integrative structures to coordinate the contributions of multiple disciplines (silos) within a firm
  • the benefits of organizational slack (e.g., dedicated resources for innovation, latitude for long-term thinking and commitment to projects)
  • a focus on the process of change and not just the structure of change
  • the need to conduct integrative programs of change that recognize the importance of articulating changes in one part of the firm with changes in other, related parts of the firm

Some common themes emerge from this list: balance, sourcing of ideas, integration, latitude and slack, and process.

In partial validation of this list, Boston Consulting Group consultants have identified their own list of "process" skills based on recent field research and have labeled them "high science." These skills include: R&D governance (e.g., using milestones as learning exercises, analytical tools, and decision-making criteria), the use of measurement systems that balance short-term and long-term perspectives and integrate the efforts of the entire R&D team, and the use of incentives that keep innovators motivated.16

The organizational innovation perspective is used here to highlight the different managerial skills required in the development of a start-up firm in the biotechnology sector and in the coordination of the internal and external activities of a large pharmaceutical firm. It is also used to explain why M&As within the pharmaceutical sector often fail to achieve their intended results. The perspective is helpful in understanding why new technology often fails to be widely adopted by the intended end user (e.g., the physician) by virtue of neglecting how it disrupts the work routines of professionals.

Why study the producers of healthcare products?

Ignored in traditional curricula of health administration

The producers of innovative products in the healthcare industry are virtually ignored in most graduate-level courses in health administration taught in schools of business and public health. A quick perusal of the most popular introductory texts reveals few, if any, chapters dedicated to the product sectors of the industry.17 The handful of texts that do include some discussion typically offer a cursory examination of the pharmaceutical sector (e.g., the role of the Food and Drug Administration, the price and value of drugs), but few discuss industry dynamics and company business models.

Similarly, there are few graduate programs in health administration that include dedicated courses on these industry sectors. The Wharton School is one of a very small number of business schools that include courses on pharmaceuticals and devices (at both undergraduate and graduate levels), as well as dedicated lectures on each of the product sectors in the introductory MBA-level course.

The failure to understand these sectors can foster a limited and narrow view of the overall industry on the part of academic researchers and executives of health provider organizations. Graduate curriculums of health administration devote considerable attention to the purchaser and provider sectors of the industry, along with the fiscal intermediaries that separate them (see figure 1.1). This is understandable, given that (a) healthcare policy focuses heavily on governmental regulation and reimbursement of health services, and (b) the bulk of academic research is conducted on these sectors of the healthcare industry. With a handful of exceptions, most researchers have not considered the implications of developments in the "producer" side of the industry for the purchaser and provider sectors. Consequently, the majority of graduates of health administration programs receive little formal training on the healthcare industry sectors that manufacture the products utilized by providers and consumed by patients.

Failure to fully appreciate the technological imperative

Why might this be of concern? As an illustration, one cannot fully understand the technological imperative in the US healthcare system unless one understands the relationship that vendors of new products have with individual physicians. The failure to understand this relationship can undermine efforts by health provider organizations to control their own costs. Executives of provider organizations may not fully appreciate that their physicians often develop closer alliances and attachments to the manufacturing firms than to their own organizations. These attachments have as much to do with the innovative features of the products made as with the intense sales and marketing support that goes with them. Indeed, vendors and physicians have developed a two-way exchange of mutual benefits that executives and purchasers may have trouble modifying. For their part, vendors offer clinicians access to the latest technology, information about the product, assistance and training in its use, involvement in clinical trials, training of the clinician's residents and nursing team, donations and honoraria, and opportunities for "naming" rights on new equipment. For their part, clinicians offer to vendors thought leadership, avenues for influencing colleagues to use the product, feedback on the product to assist with next generation product development, leaders for clinical trials, and access to patients.

Payer and provider difficulties in controlling the diffusion of technology

Countries such as the United States lack centralized allocation of capital by the government, and are witnessing the dismantling of regulation surrounding the allocation of capital (e.g., the gradual demise of "Certificate of Need," or CON programs in the fifty states). Moreover, a recent two-year review of competition and regulation by the Federal Trade Commission in the US calls for the abolition of CON laws.18 Given this state of affairs, providers will become even more responsible for controlling the diffusion of new technology.

However, based on the preceding section, purchasers and providers will thus likely face difficulties in controlling the diffusion of new technology. Moreover, provider organizations may face unforeseen difficulties in developing "integrated delivery networks" (IDNs) to partner with their physicians, and launching "value analysis committees" with their clinicians to control the selection, prices, and utilization of high-cost supplies. In both instances, the physicians' loyalty lies elsewhere.

Lack of provider focus on upstream supply costs

To aggravate this problem, many provider organizations have concerned themselves primarily with the "downstream" portions of the value chain - that is,

© Cambridge University Press

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Table of Contents

1 The business of healthcare innovation in the Wharton School curriculum 1
2 The pharmaceutical sector 27
3 The biotechnology sector - therapeutics 103
4 Biotechnology business and revenue models : the dynamic of technological evolution and capital market ingenuity 190
5 Mergers, acquisitions, and the advantages of scale in the pharmaceutical sector 223
6 The medical device sector 271
7 The healthcare information technology sector 322
8 Healthcare innovation across sectors : convergences and divergences 348
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  • Anonymous

    Posted September 18, 2005

    The Business of Healthcare Innovation - Highly Recommended

    The market dynamics, business models, and corporate strategies of pharma, biotech, genomics, medical device development, and health care information technology are converging. And you better get ready. Written by business gurus at the Wharton School and health industry executives, The Business of Healthcare Innovation provides an invaluable analysis of key business trends in the manufacturing side of health care. Editor Lawton R. Burns, Ph.D. and contributors focus on the producer side of health care and demonstrate how manufacturers serve as the principal drivers of health care innovation. Specifically, The Business of Healthcare Innovation: 1. Provides an insightful, detailed overview of the most influential players - namely, the pharmaceutical, biotechnology, genomics/proteomics, medical device, and information technology sectors. 2. Describes and assesses the market structures, business models, and corporate strategies of each of these six sectors. 3. Shows how the six sectors are converging, drawing increasingly on the trends, tools, and solutions of each other. A compelling, business-savvy look at the manufacturing side of health care, The Business of Healthcare Innovation is highly recommended for executives, policy makers, investors, and consultants to business and government decision makers.

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