Calcium in Drug Actions / Edition 1

by Peter F. Baker

Overview

The Editorial Board and the Publishers of the Handbook of Experimental Pharmacology wish to express their profound grief at the untimely death of Professor Peter Baker. Aware of his international recognition as an expert on the ubiquitous role of calcium in physiological processes and their pharma­ cological control, the Board was gratified when Professor Baker accepted its invitation to edit a new Handbook volume on "Calcium in Drug Actions". He went about this task with his usual energy and effectiveness so that, in the few months before his unexpected death, Professor Baker had mustered his distinguished contributors, got them to provide their manuscripts, and seen almost the entire material into the press. This achievement is all the more remarkable when one bears in mind the extraordinary number of his other commitments during the same time; they are mentioned in Sir Alan Hodgkin's preface to this volume. With so many other professional and personal responsibilities upon him, the Board of the Handbook wishes to record its grateful appreciation for the admirable way in which Professor Baker took on and carried out the additional work of bringing this fine book into existence; and the Board wishes it to be dedicated to the memory of Professor Peter Frederick Baker. The Editorial Board: G. V. R. BORN, P. CUATRECASAS, H. HERKEN, A.

Product Details

ISBN-13:	9783642718083
Publisher:	Springer Berlin Heidelberg
Publication date:	12/13/2011
Series:	Handbook of Experimental Pharmacology , #83
Edition description:	Softcover reprint of the original 1st ed. 1988
Pages:	567
Product dimensions:	6.69(w) x 9.53(h) x 0.05(d)

Table of Contents

1 The Multiple Physiological Roles of Calcium: Possible Sites for Pharmacological Intervention.- References.- Calcium Receptors and Calcium Metabolism.- 2 Chemical Factors Determining the Affinity of a Receptor for Calcium.- 3 Troponin C and Calmodulin as Calcium Receptors: Mode of Action and Sensitivity to Drugs.- 4 Ligand-Binding Sites on Calmodulin.- 5 Calcium Channels as Drug Receptors.- 6 The Chemistry of Calcium Channel Agonists and Antagonists.- 7 The Apamin-Sensitive Ca2+-Dependent K+ Channel: Molecular Properties, Differentiation, Involvement in Muscle Disease, and Endogenous Ligands in Mammalian Brain.- 8 Drug Effects on Plasma Membrane Calcium Transport.- 9 Development of Inhibitors of Sodium, Calcium Exchange.- 10 The Effect of Ruthenium Red and Other Agents on Mihondrial Calcium Metabolism.- 11 Pharmacology of Calcium Uptake and Release from the Sarcoplasmic Reticulum: Sensitivity to Methylxanthines and Ryanodine.- 12 Effect of Lithium in Stimulus-Response Coupling.- 13 Phorbol Esters and Protein Kinase C.- Calcium and Physiological Function.- 14 Drugs Acting on Calcium Channels.- 15 Calcium and Synaptic Function.- 16 Some New Questions Concerning the Role of Ca2 + in Exocytosis.- 17 Exo-Endocytosis: Mechanisms of Drug and Toxin Action.- 18 Pharmacology of Calcium Metabolism in Smooth Muscle.- 19 Drugs Affecting Cardiac Calcium Metabolism.- 20 Hormonal Control of Extracellular Calcium.- 21 Bisphosphonates: A New Class of Drugs in Diseases of Bone and Calcium Metabolism.- 22 Calcium and Hypertension.- Drugs and Toxicological Agents that Either Mimic Calcium or Elements of Intracellular Calcium Metabolism.- 23 Calcium Chelators and Calcium Ionophores.- 24 Lead-Calcium Interactions and Lead Toxicity.- 25 Alkaline Earths, Transition Metals, and Lanthanides.