Calcium-Sensing Receptor / Edition 1by Naibedya Chattopadhyay
Pub. Date: 12/31/2002
Publisher: Springer US
Chattopadhyay and Brown (both of the endocrine-hypertension division of a Harvard Medical School hospital) present an overview of current knowledge of the human calcium-sensing receptor's (CaR) biochemistry, physiology, and pathophysiology for both those who have been working in the field of extracellular ionized calcium concentration and those who are new to the field. Twelve contributions explore the roles of the CaR in regulating the function of tissues in kidney, bone, and intestine; explore diseases that may arise from CaR malfunction; and discuss possibilities that CaR plays regulatory roles in the central nervous system and skin. Annotation (c)2003 Book News, Inc., Portland, OR
Table of ContentsContributors. Preface; N. Chattopadhyay, E.M. Brown. 1. An overview of extracellular calcium homeostasis and the roles of the CaR in the parathyroid and C-cells; A. Mithal, E.M. Brown. 2. Structure-function relationship of the extracellular calcium-sensing receptor; Mei Bai. 3. Calcium receptor-mediated signaling; K.D. Rodland. 4. Extracellular Ca2+- sensing receptor and kidney function; D. Riccardi, S.C. Hebert. 5. Calcium- sensing receptor in bone; T. Yamaguchi. 6. Functions in the calcium-sensing receptor in the gastrointestinal system; R.J. MacLeod. 7. The calcium-sensing receptor (CaR) and human disease; C.H. Kos, M.R. Pollak. 8. Compounds acting on the parathyroid calcium receptor as novel therapies for hyperparathyroidism or osteoporosis; E.F. Nemeth, J. Fox. 9. Alternative agonists and modulators: evidence that the calcium sensing receptor is a multi-modal sensor; S.J. Quinn, A.D. Conigrave. 10. Expression and functions of calcium-sensing receptor in the central nervous system; Chianping Ye, et al. 11. The role of the calcium receptor in calcium regulated keratinocyte differentiation; Chia-Ling Tu, et al. Calcium sensing receptor and neoplastic transformation; E. Kállay, et al.
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