Calcium Signalling in Cancer

by G. V. Sherbet

Overview

Calcium signalling occupies a preeminent position in the signal transduction system of the cell by virtue of its participation in a wide range of physiological functions together with the biological events associated with genetic expression, cell proliferation and apoptosis, as well as cell differentiation and morphogenesis. It is an important feat

Product Details

ISBN-13:	9781040202272
Publisher:	CRC Press
Publication date:	11/29/2000
Sold by:	Barnes & Noble
Format:	eBook
Pages:	384
File size:	3 MB

Table of Contents

Preface. Abbreviations. Introduction. The Calcium Signalling Pathway. Calcium Binding Proteins and Their Natural Classification. Non-EF-Hand Calcium Binding Proteins. The EF-Hand Calcium Binding Proteins. The Calmodulin Family of Calcium Binding Proteins. The Structure of Contractile Proteins. The Structure and Biology of Calbindin. Calretinin: Its Role in Cell Differentiation and as a Potential Tumour Marker. Calcineurin in Cell Proliferation, Cell Adhesion, and Cell Spreading. Centrins (Caltractins) and Their Biological Functions. Reticulocalbin Family of EF-Hand Proteins. Calpains in Normal and Aberrant Cell Physiology. Caspases in Apoptosis, Cell Migration, Proliferation, and Neoplasia. Parvalbumins In Neuronal Development, Differentiation, and Proliferation. Osteonectin In Cell Function And Behavior. S100 Proteins: Their Biological Function And Role In Pathogenesis. Epilogue. References. Index.

Editorial Reviews

This treatise on the transduction signals induced by calcium considers how alterations in this calcium-dependent signal transduction pathway are related to a number of human diseases, especially neoplastic transformation. The text examines the various signalling pathways along with associated mechanisms. It also explores topics like mechanisms and significance of calcium homeostasis, calcium signalling pathways, and the transduction of the calcium signal (especially in proliferation, cell motility, cancer invasion, and metastasis. Annotation c. Book News, Inc., Portland, OR (booknews.com)

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