Caliciviruses: Molecular and Cellular Virology

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Overview

Caliciviruses are positive-sense, single stranded RNA viruses containing four recognized genera: Norovirus, Sapovirus, Lagovirus, and Vesivirus. They are ubiquitous in the environment and are a major cause of disease in humans as well as many animals. Examples include Norwalk virus - a norovirus, thought to be responsible for roughly 90% of epidemic, non-bacterial outbreaks of gastroenteritis in humans around the world. The lack of a suitable cell culture system for human caliciviruses has limited studies in previous decades, however the recent application of modern genomic technologies has revolutionized the field, leading to an explosion in calicivirus publications. In this book, a panel of experts distil the most important up-to-date research findings in their respective calicivirus field of study, producing timely and comprehensive reviews. Each chapter gives the reader a brief introduction to the topic, followed by a descriptive discussion of the past and present research areas. Topics include: norovirus epidemiology
• calicivirus contamination of the environment
• genome organization and recombination, proteolytic cleavage, and viral proteins
• viral protein structures
• virus-host interactions
• calicivirus reverse genetics and replicon systems
• feline calicivirus
• swine calicivirus
• murine norovirus pathogenesis and immunity
• murine norovirus translation, replication, and reverse genetics
• and lagoviruses. This book will be essential reading for all virologists working on caliciviruses and related viruses and is recommended for all virology, immunology, and molecular biology laboratories.
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Editorial Reviews

Doody Reviews
Reviewer: Rebecca T. Horvat, PhD, D (ABMM) (University of Kansas Medical Center)
Description: Caliciviruses infect a large range of animals and can cause disease in most of these hosts. This book is an up-to-date review of the research topics that will help illustrate the disease process and potential preventive measures.
Purpose: It provides both basic information on the caliciviruses and the new experimental data that leads to a better understanding of the diseases associated with the virus. This information should lead to better treatment, prevention, and vaccination against this virus.
Audience: The target audience is both research and industrial scientists, and the book is appropriate for scientists interested in viral infections and vaccine research. The authors have provided important reviews of the current status of research in this area of virology.
Features: Each chapter starts with a review of the topic and a description of current research concerns and future perspectives. Caliciviruses contain a large number of viruses that have a positive sense RNA genome. They also infect a broad range of hosts in addition to humans. The most well-known virus in this group is the norovirus that has caused numerous outbreaks in humans but also can infect swine, bovine, ovine, murine, and feline species. The virus is shed in very high numbers in the stool of these animals and shedding often continues as long as four weeks after clinical symptoms resolve. Transmission can occur person to person or can be associated with contaminated food or water. In humans there is no apparent long term immunity, thus they may become infected repeatedly. All of these issues make it difficult to prevent disease in humans and animals. The studies presented in this book provide the scientific community with an understanding of the nature of these viruses and challenge them to determine preventative strategies.
Assessment: This is a very comprehensive review of the current status of calicivirus research. This information will eventually lead to methods that help control the spread of this virus.
Doody's Review Service
Reviewer: Rebecca T. Horvat, PhD, D (ABMM)(University of Kansas Medical Center)
Description: Caliciviruses infect a large range of animals and can cause disease in most of these hosts. This book is an up-to-date review of the research topics that will help illustrate the disease process and potential preventive measures.
Purpose: It provides both basic information on the caliciviruses and the new experimental data that leads to a better understanding of the diseases associated with the virus. This information should lead to better treatment, prevention, and vaccination against this virus.
Audience: The target audience is both research and industrial scientists, and the book is appropriate for scientists interested in viral infections and vaccine research. The authors have provided important reviews of the current status of research in this area of virology.
Features: Each chapter starts with a review of the topic and a description of current research concerns and future perspectives. Caliciviruses contain a large number of viruses that have a positive sense RNA genome. They also infect a broad range of hosts in addition to humans. The most well-known virus in this group is the norovirus that has caused numerous outbreaks in humans but also can infect swine, bovine, ovine, murine, and feline species. The virus is shed in very high numbers in the stool of these animals and shedding often continues as long as four weeks after clinical symptoms resolve. Transmission can occur person to person or can be associated with contaminated food or water. In humans there is no apparent long term immunity, thus they may become infected repeatedly. All of these issues make it difficult to prevent disease in humans and animals. The studies presented in this book provide the scientific community with an understanding of the nature of these viruses and challenge them to determine preventative strategies.
Assessment: This is a very comprehensive review of the current status of calicivirus research. This information will eventually lead to methods that help control the spread of this virus.
Read More Show Less

Product Details

  • ISBN-13: 9781904455639
  • Publisher: Caister Academic Press
  • Publication date: 6/1/2010
  • Pages: 256
  • Product dimensions: 7.10 (w) x 10.10 (h) x 0.60 (d)

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