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Doody ReviewsReviewer: Rebecca T. Horvat, PhD, D (ABMM) (University of Kansas Medical Center)
Description: Caliciviruses infect a large range of animals and can cause disease in most of these hosts. This book is an up-to-date review of the research topics that will help illustrate the disease process and potential preventive measures.
Purpose: It provides both basic information on the caliciviruses and the new experimental data that leads to a better understanding of the diseases associated with the virus. This information should lead to better treatment, prevention, and vaccination against this virus.
Audience: The target audience is both research and industrial scientists, and the book is appropriate for scientists interested in viral infections and vaccine research. The authors have provided important reviews of the current status of research in this area of virology.
Features: Each chapter starts with a review of the topic and a description of current research concerns and future perspectives. Caliciviruses contain a large number of viruses that have a positive sense RNA genome. They also infect a broad range of hosts in addition to humans. The most well-known virus in this group is the norovirus that has caused numerous outbreaks in humans but also can infect swine, bovine, ovine, murine, and feline species. The virus is shed in very high numbers in the stool of these animals and shedding often continues as long as four weeks after clinical symptoms resolve. Transmission can occur person to person or can be associated with contaminated food or water. In humans there is no apparent long term immunity, thus they may become infected repeatedly. All of these issues make it difficult to prevent disease in humans and animals. The studies presented in this book provide the scientific community with an understanding of the nature of these viruses and challenge them to determine preventative strategies.
Assessment: This is a very comprehensive review of the current status of calicivirus research. This information will eventually lead to methods that help control the spread of this virus.