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Caloric Restriction: A Key to Understanding and Modulating Aging

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Overview

For many years, it has been known that when rats and mice are given a reduced amount of food, their life span is increased and they remain healthy and vigorous at advanced ages.

What is the reason for this change in the usual pattern of aging? The evidence is overwhelming that the life extension results from a slowing of aging processes. And the factor responsible is the decrease in caloric intake. The obvious question: How does this factor work? A good question - and the reason that research on the anti-aging action of caloric restriction is today one of the most studied research areas in biological gerontology. For it is felt that if the biological mechanisms of the anti-aging action of caloric restriction can be uncovered, we would gain an understanding of the basic nature of aging processes, which would, in turn, yield possible interventions in human aging. This book aims to provide the growing number of researchers in this field (faculty, postdoctoral trainees, and graduate students) with a detailed knowledge of what is known about caloric restriction within the frame of gerontology, as well as insights on future of this field.

For many years, it has been known that when rats and mice are given a reduced amount of food, their life span is increased and they remain healthy and vigorous at advanced ages.

What is the reason for this change in the usual pattern of aging? The evidence is overwhelming that the life extension results from a slowing of aging processes. And the factor responsible is the decrease in caloric intake. The obvious question: How does this factor work? A good question - and the reason that research on the anti-aging action of caloric restriction is today one of the most studied research areas in biological gerontology. For it is felt that if the biological mechanisms of the anti-aging action of caloric restriction can be uncovered, we would gain an understanding of the basic nature of aging processes, which would, in turn, yield possible interventions in human aging. This book aims to provide the growing number of researchers in this field (faculty, postdoctoral trainees, and graduate students) with a detailed knowledge of what is known about caloric restriction within the frame of gerontology, as well as insights on future of this field

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Product Details

  • ISBN-13: 9780444511621
  • Publisher: Elsevier Science
  • Publication date: 12/20/2002
  • Series: Research Profiles in Aging Series
  • Pages: 192
  • Product dimensions: 0.50 (w) x 9.21 (h) x 6.14 (d)

Table of Contents

Preface
Ch. 1 Overview 1
Ch. 2 Mortality Characteristics 11
Ch. 3 Molecular and Cellular Biology 21
Ch. 4 Organismic Physiology 51
Ch. 5 Age-Associated Diseases 93
Ch. 6 Mechanisms of the Anti-Aging Action of Caloric Restriction 115
Ch. 7 Evolution of Anti-Aging Action of Caloric Restriction 157
Ch. 8 Caloric Restriction Mimetics 165
Index 179
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