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Doody's Review ServiceReviewer: Christiane Querfeld, MD (Northwestern University Feinberg School of Medicine)
Description: This is an excellent comprehensive compendium of presentations and discussions by internationally recognized experts from the symposium on Cancer and Inflammation, held at the Novartis Foundation in London in November 2002.
Purpose: Recent data have documented the concept that inflammation is a crucial component of carcinogenesis. This book provides an update of the current state of knowledge on host response mechanisms such as signaling molecules of the innate immune system, such as chemokines and their receptors contributing to tumor invasion, migration, and metastasis as well as tumor inhibition, and outlines possible targets for inhibition of these processes.
Audience: For scientists working in the research-cancer area it provides a stimulating, useful, and comprehensive outline in this area. For others unfamiliar with this subject area, it provides an extremely good overview of current understanding of the molecular basis of inflammation-associated neoplasia and of potential targets for drugs.
Features: The book starts with an epidemiological outline of chronic inflammation and cancer. A second topic covers the role of inflammatory cytokines, chemokines and their chemokine ligand/receptor system and discusses their potential role in tumorgenesis and progression as well as in tumor angiogenesis. The following topic covers immunologically activated cells such as dendritic cells, macrophages, and regulatory T-cells involved in antitumor response and tumor growth and progression with therapeutic implications leading to antitumor immunity. Finally, anticytokine therapies including anti-TNF á established in autoimmune disorders are discussed as potential new treatment modalities.
Assessment: This book of 15 reviews followed by discussion sections is highly informative, very up-to-date, and demonstrates the complex biochemical events that may result in carcinogenesis.