Cancer as a Metabolic Disease: On the Origin, Management, and Prevention of Cancer

by Thomas Seyfried

Overview

The book addresses controversies related to the origins of cancer and provides solutions to cancer management and prevention. It expands upon Otto Warburg's well-known theory that all cancer is a disease of energy metabolism.  However, Warburg did not link his theory to the "hallmarks of cancer" and thus his theory was discredited.  This book aims to provide evidence, through case studies, that cancer is primarily a metabolic disease requring metabolic solutions for its management and prevention.  Support for this position is derived from critical assessment of current cancer theories.  Brain cancer case studies are presented as a proof of principle for metabolic solutions to disease management, but similarities are drawn to other types of cancer, including breast and colon, due to the same cellular mutations that they demonstrate.

Product Details

ISBN-13:	9781118310304
Publisher:	Wiley
Publication date:	05/18/2012
Sold by:	JOHN WILEY & SONS
Format:	eBook
Pages:	448
File size:	31 MB
Note:	This product may take a few minutes to download.

About the Author

THOMAS N. SEYFRIED, PhD, has taught and conducted research in the fields of neurogenetics, neurochemistry, and cancer for more than twenty-five years at Yale University and Boston College. He has published more than 150 scientific articles and book chapters and is on the editorial boards of Nutrition & Metabolism, Journal of Lipid Research, Neurochemical Research, and ASN Neuro.

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Table of Contents

Chapter 1. Images of Cancer

Chapter 2. Confusion surrounds the origin of cancer

Chapter 3. Cancer Models

Chapter 4. Energetics of normal cells and cancer cells

Chapter 5. Respiratory Dysfunction in Cancer Cells

Chapter 6. The Warburg Dispute

Chapter 7. Is Respiration Normal in Most Cancer Cells?

Chapter 8. Is Mitochondrial Glutamine Fermentation the Missing Link in the Metabolic Theory of Cancer?

Chapter 9. Genes, Respiration, Viruses, Cancer

Chapter 10. Respiratory Injury, the retrograde response, and the origin of cancer

Chapter 11. Mitochondria: The ultimate tumor suppressor

Chapter 12. Linking Abnormalities in Growth Control, Telomerase Activity

Chapter 13. Metastasis

Chapter 14. Mitochrondrial Respiratory Dysfunction and the Extrachromosomal Origin of Cancer

Chapter 15. Nothing in Cancer Biology Makes Sense Except in the Light of Evolution

Chapter 16. Cancer Treatment Strategies

Chapter 17. Metabolic management of cancer

Chapter 18. Implementation of Metabolic Therapies for Cancer Management

Chapter 19. Cancer Prevention

Chapter 20. Case Studies and Personal Experiences in Using the Ketogenic Diet for Cancer Management

Chapter 21. Conclusions

What People are Saying About This

From the Publisher

“This book offers a refreshing perspective for anyone wanting to get a comprehensive background on the newer emerging interest in targeting cancer metabolism for therapy.” (Doody’s, 11 January 2013)

“For the first time, an entire issue is being devoted to a review article based on a recent medical book. This is a departure from our usual format, but I think you will agree that this topic warrants the detailed treatment we have given it . . .This book should be required reading for all scientifically literate people who are involved in the cancer problem.” (Advances in Cancer Treatment, 1 October 2012)

Editorial Reviews

Reviewer: Mala Shanmugam, PhD. (Northwestern University Feinberg School of Medicine)
Description: This is a refreshing, comprehensive analysis of the importance of investigating cancer metabolism. The author aptly suggests through citation of pertinent literature how abnormal tumor metabolism may indeed be the driver of genomic instability and tumor progression.
Purpose: The purpose is to underscore and re-engage interest in the investigation of abnormal tumor cell metabolism as the basis of cancer evolution and progression. The book is indeed relevant, given the current resurgence of interest in this area.
Audience: Any biologist with a high school background on would find this informative.
Features: The author provides a basic overview of the state of cancer research, how abnormalites in cancer metabolism were discovered close to 100 years ago, how research is currently centered on investigating the genomic basis of cancer, and how we need to refocus our investigations into cancer metabolism to conquer cancer.
Assessment: This book offers a refreshing perspective for anyone wanting to get a comprehensive background on the newer emerging interest in targeting cancer metabolism for therapy.

Doody's Review Service

This book offers a refreshing perspective for anyone wanting to get a comprehensive background on the newer emerging interest in targeting cancer metabolism for therapy.”  (Doody’s, 11 January 2013)

“For the first time, an entire issue is being devoted to a review article based on a recent medical book. This is a departure from our usual format, but I think you will agree that this topic warrants the detailed treatment we have given it . . .This book should be required reading for all scientifically literate people who are involved in the cancer problem.”  (Advances in Cancer Treatment, 1 October 2012)

From the Publisher