Cancer Biology / Edition 4

Paperback (Print)
Buy Used
Buy Used from
(Save 34%)
Item is in good condition but packaging may have signs of shelf wear/aging or torn packaging.
Condition: Used – Good details
Used and New from Other Sellers
Used and New from Other Sellers
from $34.18
Usually ships in 1-2 business days
(Save 53%)
Other sellers (Paperback)
  • All (8) from $34.18   
  • New (4) from $65.96   
  • Used (4) from $34.18   


The fourth edition of this classic text provides a thorough yet concise, review of the cellular and molecular mechanisms involved in the transformation of normal into malignant cells, as well as the hallmarks of cancer cells' behavior in host tissues. It defines the fundamental pathophysiologic changes that occur in tumor tissue and in the host animal or patient. Each chapter discusses the historical development of a field, citing the key experimental advances to the present day, and evaluates the current evidence that best supports or rules out concepts of the molecular and cellular mechanisms regulating cancer cell behavior. For all the areas of fundamental cancer research, an effort has been made to relate basic research findings to the clinical disease states. Clearly written and well illustrated, there is also an extensive, up-to-date bibliography, making the book valuable to basic scientists, physicians, nurses, and students interested in the field. The topics covered include pathologic characterization of human tumors, epidemiology of human cancer, regulation of cell proliferation and differentiation, cellular and molecular genetic characteristics of the cancer cell, mechanisms of carcinogenesis, tumor initiation and promotion, viral carcinogenesis, oncogenes and oncogene products growth factors, chromosomal alterations in cancer, mechanisms of tumor metastasis, host-tumor interactions, fundamental aspects of tumor immunology, and the advances in cancer cell biology that will lead to improved diagnosis, treatment, and prevention of cancer in the future.

About the Author:
Raymond Ruddon's served as the Associate Director for Basic Science Research of theUniversity's Comprehensive Cancer Center

The book contains black-and-white illustrations.

Read More Show Less

Editorial Reviews

Doody's Review Service
Reviewer: Jill C. Pelling, PhD (Northwestern University Feinberg School of Medicine)
Description: This comprehensive book reviews the principles and mechanisms of carcinogenesis as well as the epidemiology of human cancer, cancer diagnosis, and cancer prevention. A wide spectrum of important topics are covered, including the characteristics of cancer, causes, epidemiology, cancer cell biochemistry and molecular genetics, tumor immunology, and cancer diagnosis, treatment, and prevention. All nine chapters have been updated from the third edition published in 1995.
Purpose: The purpose is to provide students, as well as basic and translational cancer researchers and clinical researchers, with a common framework of the fundamental concepts and pathways of carcinogenesis as well as perspectives on future directions and issues in the field of cancer biology. As with the previous three editions, a significant strength of this book is the discussion of key historical discoveries and advances in cancer research over the past 230 years. A laudable goal of this fourth edition is to educate graduate students who are beginning their training on the important discoveries made by the early pioneers in the fields of experimental, clinical, and epidemiological cancer research.
Audience: The author has targeted this book at advanced students and researchers in the fields of cancer biology and translational cancer research.
Features: Excellent chapters cover the major topics in cancer biology and include extensive bibliography sections. The black-and-white diagrams are for the most part clear and well executed. New to this edition are a series of color glossy figures that illustrate a number of signaling pathways as well as schematics that illustrate various methodologies such as dual-modality reporter gene imaging, MALDI-tof mass spectrometry, and microarray analysis by hierarchical clustering.
Assessment: Overall this is a well crafted book for graduate students and cancer researchers who wish to learn more about the key concepts and pathways involved in the rapidly advancing field of cancer biology.
From the Publisher

From reviews of previous editions: "Highly recommended for readers who wish to spend several hours with a well-written, well-selected, effectively illustrated, and well-integrated overview of the sciences that join to make up the field of tumor biology." --New England Journal of Medicine

"I can think of no better introduction for a graduate student to contemporary cancer research, especially at the cellular level." --The Times Higher Education Supplement

Read More Show Less

Product Details

  • ISBN-13: 9780195175448
  • Publisher: Oxford University Press, USA
  • Publication date: 3/15/2007
  • Edition description: REV
  • Edition number: 4
  • Pages: 568
  • Sales rank: 1,234,150
  • Product dimensions: 10.00 (w) x 7.00 (h) x 1.30 (d)

Table of Contents

1 Characteristics of human cancer 3
2 The epidemiology of human cancer 19
3 Genetic alterations in cancer cells 61
4 Phenotypic characteristics of cancer cells 96
5 Alterations of cellular differentiation in cancer 141
6 Causes of cancer 231
7 Oncogenes 277
8 Tumor suppressor genes 318
9 Growth factors and signal transduction mechanisms 341
10 Cell-cycle regulation and apoptosis 386
11 Biology of tumor metastasis 402
12 Host-tumor interactions: Tumor effects on the host 428
13 Tumor immunology: Immunologic approaches to the diagnosis and treatment of cancer 442
14 Gene-targeted therapy for cancer 476
15 Cancer prevention 497
Index 511
Read More Show Less

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star


4 Star


3 Star


2 Star


1 Star


Your Rating:

Your Name: Create a Pen Name or

Barnes & Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation


  • - By submitting a review, you grant to Barnes & and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Terms of Use.
  • - Barnes & reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)