Cancer Biology / Edition 3

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Provides a clear, concise and authoritative introduction to the biological principles that underlie the causes and treatment of cancer. The authors draw on their extensive teaching experience to guide students through this complex subject, and knit together the diverse areas encompassed in the study of cancer. This third edition is updated to include areas of recent research which excite student interest.

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Product Details

  • ISBN-13: 9780131294547
  • Publisher: Benjamin Cummings
  • Publication date: 5/26/2006
  • Edition description: Revised Edition
  • Edition number: 3
  • Pages: 312
  • Product dimensions: 7.50 (w) x 9.70 (h) x 0.80 (d)

Table of Contents

Detailed contents


Preface to the second edition

Preface to the first edition


Basic science, terminology and abbreviations

1. What is cancer?


Carcinogenesis requires several cellular changes

Lifestyle and family influences on cancer

Changes continue to accumulate after cancer formation

Cancers are most common in epithelial cells

Cancer results from uncontrolled growth

Cancer genes

Invasion and metastasis

Some cancers are curable

Prevention, screening and treatment

Further reading


2. Natural history: the life of a cancer


Clonal origins of cancer

Experimental biology

Box2.1: Special mice used in cancer research

Clinical data

Linking laboratory and clinic

3. Pathology: defining a neoplasm


Box3.1: Classifying cancers




Molecular techniques

Further reading

4. Epidemiology: identifying causes for human cancers


Descriptive epidemiology

Box4.1: Epidemiological methods and terminology

Analytical epidemiology

Criteria required to establish causality


Molecular epidemiology

Factors that influence human carcinogenesis

Cancer prevention

Further reading

5. Oncogenes, tumour suppressor genes and viruses


Box5.1: Molecular terms relevant to genes and their regulation


Tumour suppressor genes

Oncogenes and tumour suppressors cooperate

Further reading

6. Chemical and radiation carcinogenesis


Chemical carcinogenesis

Radiation carcinogenesis

Consequences of DNA damage

Predicting the type of carcinogen by mutational spectrum analysis

Further reading

7. Mutations, DNA repair and genetic instability



Genetic instability

Types of DNA damage

Clinical evidence that links DNA repair and carcinogenesis

Repair mechanisms

Coordination of DNA repair, proliferation and apoptosis

Further reading

8. Familial cancers


Box8.1: Chromosome nomenclature and structure

Strong familial link

Weaker familial link

Connection with sporadic cancers

Further reading

9. Growth: a balance of cell proliferation, death and differentiation


Normal proliferation and its regulation

Box9.1: BNA synthesis and telomere length

Cancer cells

Senescence, cell mortality and telomerase

Cell death

Apoptosis and cancer

Integration of proliferation, apoptosis and DNA repair


Further reading

10. Responding to the environment: growth regulation and signal transduction

General features

Growth factors

Growth factor receptors

Growth factors: from membrane to nucleus

Nuclear events stimulated by growth factors

Cell adhesion molecules

Box10.1: How a cell interacts with its environment

Hydrophobic growth regulatory molecules

Cross-talk between signalling pathways

Further reading

11. Invasion and metastasis


General features

Escape from local control and invasion



Gene changes involved in metastasis

Further reading

12. Principles of cancer treatment


Principles behind the treatment of cancer


Hormone therapy

Immunotherapy/biological response modifier therapy

Photodynamic therapy

New forms of treatment

Further reading

13. Approaches to cancer prevention


Breast cancer, tamoxifen and anastrozole

Endometrial/ovarian cancer and the contraceptive pill

Coloncancer and non-steroidal anti-inflammatory drugs


Further reading

Appendix: Features of selected cancers



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