Cancer Biology / Edition 3

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Overview

Provides a clear, concise and authoritative introduction to the biological principles that underlie the causes and treatment of cancer. The authors draw on their extensive teaching experience to guide students through this complex subject, and knit together the diverse areas encompassed in the study of cancer. This third edition is updated to include areas of recent research which excite student interest.

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Product Details

  • ISBN-13: 9780131294547
  • Publisher: Benjamin Cummings
  • Publication date: 5/26/2006
  • Edition description: Revised Edition
  • Edition number: 3
  • Pages: 312
  • Product dimensions: 7.50 (w) x 9.70 (h) x 0.80 (d)

Table of Contents

Detailed contents

Preface

Preface to the second edition

Preface to the first edition

Acknowledgements

Basic science, terminology and abbreviations

1. What is cancer?

Introduction

Carcinogenesis requires several cellular changes

Lifestyle and family influences on cancer

Changes continue to accumulate after cancer formation

Cancers are most common in epithelial cells

Cancer results from uncontrolled growth

Cancer genes

Invasion and metastasis

Some cancers are curable

Prevention, screening and treatment

Further reading

Websites

2. Natural history: the life of a cancer

Introduction

Clonal origins of cancer

Experimental biology

Box2.1: Special mice used in cancer research

Clinical data

Linking laboratory and clinic

3. Pathology: defining a neoplasm

Introduction

Box3.1: Classifying cancers

Histopathology

Cytology

Immunohistochemistry

Molecular techniques

Further reading

4. Epidemiology: identifying causes for human cancers

Introduction

Descriptive epidemiology

Box4.1: Epidemiological methods and terminology

Analytical epidemiology

Criteria required to establish causality

Biomarkers

Molecular epidemiology

Factors that influence human carcinogenesis

Cancer prevention

Further reading

5. Oncogenes, tumour suppressor genes and viruses

Introduction

Box5.1: Molecular terms relevant to genes and their regulation

Oncogenes

Tumour suppressor genes

Oncogenes and tumour suppressors cooperate

Further reading

6. Chemical and radiation carcinogenesis

Introduction

Chemical carcinogenesis

Radiation carcinogenesis

Consequences of DNA damage

Predicting the type of carcinogen by mutational spectrum analysis

Further reading

7. Mutations, DNA repair and genetic instability

Introduction

Mutations

Genetic instability

Types of DNA damage

Clinical evidence that links DNA repair and carcinogenesis

Repair mechanisms

Coordination of DNA repair, proliferation and apoptosis

Further reading

8. Familial cancers

Introduction

Box8.1: Chromosome nomenclature and structure

Strong familial link

Weaker familial link

Connection with sporadic cancers

Further reading

9. Growth: a balance of cell proliferation, death and differentiation

Introduction

Normal proliferation and its regulation

Box9.1: BNA synthesis and telomere length

Cancer cells

Senescence, cell mortality and telomerase

Cell death

Apoptosis and cancer

Integration of proliferation, apoptosis and DNA repair

Differentiation

Further reading

10. Responding to the environment: growth regulation and signal transduction

General features

Growth factors

Growth factor receptors

Growth factors: from membrane to nucleus

Nuclear events stimulated by growth factors

Cell adhesion molecules

Box10.1: How a cell interacts with its environment

Hydrophobic growth regulatory molecules

Cross-talk between signalling pathways

Further reading

11. Invasion and metastasis

Introduction

General features

Escape from local control and invasion

Intravasation

Angiogenesis

Gene changes involved in metastasis

Further reading

12. Principles of cancer treatment

Introduction

Principles behind the treatment of cancer

Chemotherapy

Hormone therapy

Immunotherapy/biological response modifier therapy

Photodynamic therapy

New forms of treatment

Further reading

13. Approaches to cancer prevention

Introduction

Breast cancer, tamoxifen and anastrozole

Endometrial/ovarian cancer and the contraceptive pill

Coloncancer and non-steroidal anti-inflammatory drugs

Diet

Further reading

Appendix: Features of selected cancers

Glossary

Index

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