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Updated to include the newest drugs and those currently in development, Cancer Chemotherapy and Biotherapy, Fifth Edition is a comprehensive reference on the preclinical and clinical pharmacology of anticancer agents. Organized by drug class, the book provides the latest information on all drugs and biological agents—their mechanisms of action, interactions with other agents, toxicities, side effects, and mechanisms of resistance. Chapters emphasize pharmacology and mechanisms of action at the molecular and cellular levels, followed by clinical activity and toxicity, both acute and delayed. The authors explain the rationale for use of drugs in specific schedules and combinations and offer guidelines for dose adjustment in particular situations.
This edition's introduction includes timely information on general strategies for drug usage, the science of drug discovery and development, economic and regulatory aspects of cancer drug development, and principles of pharmacokinetics. Eight new chapters have been added and more than twenty have been significantly revised.
A companion website includes the fully searchable text and an image bank.
The book contains predominantly black-and-white illustrations, with some color illustrations.
|1||Clinical strategies for cancer treatment : the role of drugs||1|
|2||Preclinical aspects of cancer drug discovery and development||15|
|4||Infertility after cancer chemotherapy||45|
|5||Carcinogenesis of anticancer drugs||70|
|12||Clinical and high-dose alkylating agents||283|
|14||Cisplatin, carboplatin, and oxaliplatin||332|
|17||Topoisomerase I-targeting drugs||371|
|18||Anthracyclines and anthracenediones||414|
|19||Topoisomerase II inhibitors : the epipodophyllotoxins, acridines, and ellipticines||451|
|21||Delivering anticancer drugs to brain tumors||484|
|22||Food and drug administration role in oncology product development||502|
|23||Central venous catheters : care and complications||516|
|25||New targets for anticancer therapeutics||549|
|27||Thalidomide and its analogs for the treatment of hematologic malignancies, including multiple myeloma, and solid tumors||587|
|28||Inhibitors of tumor angiogenesis||605|
|30||Molecular targeted drugs and growth factor receptor inhibitors||641|
|31||Antibody therapies of cancer||666|
|33||Adoptive cellular therapies||718|
|35||Hematopoietic growth factors||747|
|37||Hormonal therapy for breast cancer||809|