Cancer Chemotherapy and Biotherapy: Principles and Practice / Edition 3

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Overview

Updated to include the newest drugs and those currently in development, Cancer Chemotherapy and Biotherapy, Fifth Edition is a comprehensive reference on the preclinical and clinical pharmacology of anticancer agents. Organized by drug class, the book provides the latest information on all drugs and biological agents—their mechanisms of action, interactions with other agents, toxicities, side effects, and mechanisms of resistance. Chapters emphasize pharmacology and mechanisms of action at the molecular and cellular levels, followed by clinical activity and toxicity, both acute and delayed. The authors explain the rationale for use of drugs in specific schedules and combinations and offer guidelines for dose adjustment in particular situations.

This edition's introduction includes timely information on general strategies for drug usage, the science of drug discovery and development, economic and regulatory aspects of cancer drug development, and principles of pharmacokinetics. Eight new chapters have been added and more than twenty have been significantly revised.

A companion website includes the fully searchable text and an image bank.

The book contains predominantly black-and-white illustrations, with some color illustrations.

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Editorial Reviews

Claudia Tellez
This second edition is published as a follow-up to The Pharmacologic Principles of Cancer Treatment, originally released in 1982. It provides a comprehensive review of new and old chemotherapy and biologic agents, while also providing a discussion of other related topics such as potential long-term toxicities and routes of administration. The purpose of this book is to provide a detailed review of new and old chemotherapeutic and biologic agents, including the basis for their use, aspects of pharmacology, and guidelines for safe clinical use. A provocative role for the combination of chemotherapeutic and biologic agents is also presented. This publication is a very useful review, because the authors are highly successful at thoroughly presenting the topics. This textbook will appeal to a wide range of audiences from a student to a practitioner level. It may also be a useful reference for scientific investigators. Some chapters may even provide general information that could be used for patient education. All the authors are well known and respected clinicians and investigators. The text features numerous graphs, charts, and illustrations that appropriately assisted in the presentation of the material. The large number of references available at the end of each chapter are very current and may serve as a useful research tool. The appearance of the book is professional, and the layout of the topics is rational and easy to follow. This is a very useful book that will serve a diverse audience. The book would be appropriate for a library reference or for personal use. This book is the second edition and serves as a thorough and useful follow-up to the initialreview published in 1982.
From The Critics
Reviewer: Lili Wang, MD (Northwestern University Feinberg School of Medicine)
Description: This is a very useful reference book for clinical practitioners as well as residents and fellows who just enter the field.
Purpose: The book intends to provide information that can be used to form the starting point for the development of clinical skills. With a wealth of comprehensive information on cancer chemotherapy and biotherapy, the book lives up to its claimed objectives.
Audience: The book's intended audience is residents, fellows, and experienced practitioner, especially those in hematology/oncology specialty. The editors and contributing authors are highly credible authorities in their fields.
Features: This is one of the most comprehensive books on cancer therapies. Almost all major classes of anti-cancer drugs are covered from a brief history of drug discovery, to the mechanism of action, clinical pharmacology, application, and toxicity. The book contains the latest advances in anticancer therapies. As an added bonus, readers are treated with information on preclinical drug discovery and development, and regulatory issues in approving anticancer drugs. In addition, there is a dedicated chapter for new therapeutic targets that are being used for drug development. Even pharmacogenetics and its application in cancer treatment are covered.
Assessment: This is the 4th edition of the book. With emerging new therapies and drugs, the new edition is a timely revision to include the latest development. The book is well written and serves as a useful reference in many settings.

5 Stars! from Doody
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Product Details

  • ISBN-13: 9780781722698
  • Publisher: Lippincott Williams & Wilkins
  • Publication date: 8/28/2001
  • Edition description: Third Edition
  • Edition number: 3
  • Pages: 1152

Read an Excerpt

The skilled physicians treating patients with cancer have a daunting task in that they need to understand pharmacology, pharmacokinetics, pharmacogenetics, pharmacodynamics, drug metabolism, drug resistance, cancer cell biology, normal cell biology, and myriad drug interactions, in addition to considerations of alterations in physiology caused by the cancer or associated with concurrent disease or advanced age that influence these distinct facets that in turn influence drug action. In this book, we have attempted to incorporate relevant information that will assist the caregiver in planning the optimal treatment approach for each individual patient. It is our intention to keep the information in this text up to date through the addition of relevant information on newly approved drugs to the new online version of this book that appears at http://www.lwwoncology.com. We look forward to your feedback about how to make this book more useful to you.
—Bruce A. Chabner, M.D.,Dan L. Longo, M.D.
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Table of Contents

1 Clinical strategies for cancer treatment : the role of drugs 1
2 Preclinical aspects of cancer drug discovery and development 15
3 Pharmacokinetics 31
4 Infertility after cancer chemotherapy 45
5 Carcinogenesis of anticancer drugs 70
6 Antifolates 91
7 5-fluoropyrimidines 125
8 Cytidine analogues 183
9 Purine antimetabolites 212
10 Hydroxyurea 229
11 Antimicrotubule agents 237
12 Clinical and high-dose alkylating agents 283
13 Nonclassic agents 310
14 Cisplatin, carboplatin, and oxaliplatin 332
15 Bleomycin 344
16 Antitumor antibiotics 359
17 Topoisomerase I-targeting drugs 371
18 Anthracyclines and anthracenediones 414
19 Topoisomerase II inhibitors : the epipodophyllotoxins, acridines, and ellipticines 451
20 Asparaginase 476
21 Delivering anticancer drugs to brain tumors 484
22 Food and drug administration role in oncology product development 502
23 Central venous catheters : care and complications 516
24 Pharmacogenetics 529
25 New targets for anticancer therapeutics 549
26 Bisphosphonates 579
27 Thalidomide and its analogs for the treatment of hematologic malignancies, including multiple myeloma, and solid tumors 587
28 Inhibitors of tumor angiogenesis 605
29 Proteasome inhibitors 621
30 Molecular targeted drugs and growth factor receptor inhibitors 641
31 Antibody therapies of cancer 666
32 Interferons 699
33 Adoptive cellular therapies 718
34 Cancer vaccines 739
35 Hematopoietic growth factors 747
36 Interleukins 767
37 Hormonal therapy for breast cancer 809
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