Cancer Chemotherapy and Biotherapy: Principles and Practice / Edition 3

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Updated to include the newest drugs and those currently in development, Cancer Chemotherapy and Biotherapy, Fifth Edition is a comprehensive reference on the preclinical and clinical pharmacology of anticancer agents. Organized by drug class, the book provides the latest information on all drugs and biological agents—their mechanisms of action, interactions with other agents, toxicities, side effects, and mechanisms of resistance. Chapters emphasize pharmacology and mechanisms of action at the molecular and cellular levels, followed by clinical activity and toxicity, both acute and delayed. The authors explain the rationale for use of drugs in specific schedules and combinations and offer guidelines for dose adjustment in particular situations.

This edition's introduction includes timely information on general strategies for drug usage, the science of drug discovery and development, economic and regulatory aspects of cancer drug development, and principles of pharmacokinetics. Eight new chapters have been added and more than twenty have been significantly revised.

A companion website includes the fully searchable text and an image bank.

The book contains predominantly black-and-white illustrations, with some color illustrations.

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Editorial Reviews

Claudia Tellez
This second edition is published as a follow-up to The Pharmacologic Principles of Cancer Treatment, originally released in 1982. It provides a comprehensive review of new and old chemotherapy and biologic agents, while also providing a discussion of other related topics such as potential long-term toxicities and routes of administration. The purpose of this book is to provide a detailed review of new and old chemotherapeutic and biologic agents, including the basis for their use, aspects of pharmacology, and guidelines for safe clinical use. A provocative role for the combination of chemotherapeutic and biologic agents is also presented. This publication is a very useful review, because the authors are highly successful at thoroughly presenting the topics. This textbook will appeal to a wide range of audiences from a student to a practitioner level. It may also be a useful reference for scientific investigators. Some chapters may even provide general information that could be used for patient education. All the authors are well known and respected clinicians and investigators. The text features numerous graphs, charts, and illustrations that appropriately assisted in the presentation of the material. The large number of references available at the end of each chapter are very current and may serve as a useful research tool. The appearance of the book is professional, and the layout of the topics is rational and easy to follow. This is a very useful book that will serve a diverse audience. The book would be appropriate for a library reference or for personal use. This book is the second edition and serves as a thorough and useful follow-up to the initialreview published in 1982.
Doody's Review Service
Reviewer: Timothy M Kuzel, MD (Northwestern University Feinberg School of Medicine)
Description: This book provides a high-level overview of the current drugs, hormonal approaches, and biological therapies for cancer treatment. The chapters emphasize pharmacology and mechanisms of action at both the molecular and cellular level, and discuss clinical activity and side effects. The previous edition was published in 2009, but given the rapid pace of drug discovery with a molecular basis of action, frequent updates are required.
Purpose: The authors seek to impart the wisdom of widely recognized experts in the field of oncology and to provide a framework for informed clinical decision-making. They shy away from the use of algorithms, as no one choice of therapy in oncology is appropriate for all patients. The book provides updated information, relatively little of which cannot be gleaned from other books or even package inserts on specific therapies. Still, the rapid development of novel targeted agents requires books such as this to be published frequently on shorter turnaround times so as not be obsolete before they come on the market.
Audience: It is aimed at general oncologists or trainees in oncology. Much of the material is somewhat dry and, frankly, not relevant for clinical practitioners. The book reads more like a pharmacology text than an oncologic disease text. In an era of combination therapy, chapters focused on individual drugs are of basic interest, but again not particularly relevant in making informed treatment decisions.
Features: The book provides a single, relatively recent source of discussion of the individual agents used in oncology. It covers the basics regarding pharmacokinetics and mechanisms of action, clinical drug development leading to approval, and adverse events. Illustrations supporting the mechanisms of action are somewhat sparse, making the reading rather dry.
Assessment: Although it does serve as a single source of recent, updated information regarding the drugs used for oncology therapy, the book falls short of being a standalone "bible" for oncologists because of the lack of discussion of combinations routinely used for oncology patients in the United States and because of the less than thorough reporting of clinical benefits of the agents for treatment in a comprehensive way. More firm recommendations from the chapter authors regarding standard-of-care or state-of-the-art uses for the drugs would make the book somewhat more valuable to all readers.

5 Stars! from Doody
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Product Details

  • ISBN-13: 9780781722698
  • Publisher: Lippincott Williams & Wilkins
  • Publication date: 8/28/2001
  • Edition description: Third Edition
  • Edition number: 3
  • Pages: 1152

Read an Excerpt

The skilled physicians treating patients with cancer have a daunting task in that they need to understand pharmacology, pharmacokinetics, pharmacogenetics, pharmacodynamics, drug metabolism, drug resistance, cancer cell biology, normal cell biology, and myriad drug interactions, in addition to considerations of alterations in physiology caused by the cancer or associated with concurrent disease or advanced age that influence these distinct facets that in turn influence drug action. In this book, we have attempted to incorporate relevant information that will assist the caregiver in planning the optimal treatment approach for each individual patient. It is our intention to keep the information in this text up to date through the addition of relevant information on newly approved drugs to the new online version of this book that appears at We look forward to your feedback about how to make this book more useful to you.
—Bruce A. Chabner, M.D.,Dan L. Longo, M.D.
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Table of Contents

1 Clinical strategies for cancer treatment : the role of drugs 1
2 Preclinical aspects of cancer drug discovery and development 15
3 Pharmacokinetics 31
4 Infertility after cancer chemotherapy 45
5 Carcinogenesis of anticancer drugs 70
6 Antifolates 91
7 5-fluoropyrimidines 125
8 Cytidine analogues 183
9 Purine antimetabolites 212
10 Hydroxyurea 229
11 Antimicrotubule agents 237
12 Clinical and high-dose alkylating agents 283
13 Nonclassic agents 310
14 Cisplatin, carboplatin, and oxaliplatin 332
15 Bleomycin 344
16 Antitumor antibiotics 359
17 Topoisomerase I-targeting drugs 371
18 Anthracyclines and anthracenediones 414
19 Topoisomerase II inhibitors : the epipodophyllotoxins, acridines, and ellipticines 451
20 Asparaginase 476
21 Delivering anticancer drugs to brain tumors 484
22 Food and drug administration role in oncology product development 502
23 Central venous catheters : care and complications 516
24 Pharmacogenetics 529
25 New targets for anticancer therapeutics 549
26 Bisphosphonates 579
27 Thalidomide and its analogs for the treatment of hematologic malignancies, including multiple myeloma, and solid tumors 587
28 Inhibitors of tumor angiogenesis 605
29 Proteasome inhibitors 621
30 Molecular targeted drugs and growth factor receptor inhibitors 641
31 Antibody therapies of cancer 666
32 Interferons 699
33 Adoptive cellular therapies 718
34 Cancer vaccines 739
35 Hematopoietic growth factors 747
36 Interleukins 767
37 Hormonal therapy for breast cancer 809
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