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Cancer Chemotherapy: Concepts, Clinical Investigations and Therapeutic Advances / Edition 1

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Editorial Reviews

Booknews
Focus of these articles is on new advances such as the current status of trimetrexate, the ability to modulate the action of alkylating agents and fluorinated pyrimidines to achieve greater sensitivity, and the genetics of multidrug resistance in human tumors. Also addressed are the role of the nurse investigator, and four evolving targets of chemotherapy. Annotation c. Book News, Inc., Portland, OR (booknews.com)
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Product Details

  • ISBN-13: 9780898383812
  • Publisher: Springer US
  • Publication date: 11/30/1988
  • Series: Cancer Treatment and Research Series , #42
  • Edition description: 1989
  • Edition number: 1
  • Pages: 252
  • Product dimensions: 9.21 (w) x 6.14 (h) x 0.63 (d)

Table of Contents

I. Concepts.- 1. Alkylating agents: Mechanisms and modulation.- 2. Reduced folates and fluoropyrimidine antitumor efficacy.- 3. Laboratory aspects of multidrug resistance.- II. Initial clinical investigations.- 4. Multidrug resistance: clinical findings and implications.- 5. Current status of trimetrexate, a folate antagonist with antineoplastic and antiprotozoal properties.- 6. Daunomycin and doxorubicin LYM-1-drug conjugates for the treatment of malignant lymphomas.- 7. Phase I trials: Role of the nurse investigator.- III. Therapeutic advances.- 8. The role of chemotherapy in the treatment of squamous cell tumors of the esophagus.- 9. Systemic chemotherapy of transitional cell carcinoma of the urothelium.- 10. Nasopharyngeal cancer, undifferentiated type: The medical oncologist’s viewpoint.- 11. Primary central nervous system lymphomas.

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