Cancer Epigenetics

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During the past few decades, it has become increasingly apparent that heredity is not the sole determining factor in disease development, such as cancer. This landmark work covers a wide array of aspects in the relatively new area of epigenetics, ranging from its role in the basic mechanisms of tumorigenesis, to the newest epigenetic drugs being developed and used for cancer therapy.

Cancer Epigenetics presents in-depth discussions of DNA methylation alterations, histone and RNA modifications, and nucleosome remodeling, which are all intimately involved in the formation of tumors. It also analyzes metabolic influences on cancer epigenetics and advances in epigenetic cancer gene therapy.

Discusses the Latest Advances in the Role of Epigenetics in Tumor Initiation, Progression, and Metastasis

With stand-alone chapters written by research pioneers in the field, this definitive resource covers—

  • DNA methylation and cancer
  • Histone modifications in cancer
  • Emerging areas of cancer epigenetics
  • Epigenetics in the diagnosis, prognosis, and therapy of cancer
  • Future directions in epigenetic cancer research

Bringing together different topics into a single compilation, this text is a prime resource for those with interests ranging from the basic mechanisms of tumor biology to cancer therapy. It also serves as a core textbook for advanced courses with a focus on genetic diseases, molecular biology, and/or cancer. This seminal work answers the call for a thorough and authoritative reference that covers the critical and contemporary aspects of this revolutionary field.

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Product Details

  • ISBN-13: 9781420045796
  • Publisher: Taylor & Francis
  • Publication date: 9/8/2008
  • Pages: 472
  • Product dimensions: 7.20 (w) x 10.00 (h) x 1.10 (d)

Table of Contents

The Role of Epigenetics in Cancer, T.O. Tollefsbol
Section 1: DNA Methylation and Cancer
DNA Hypomethylation in Cancer, P.L. Molloy
DNA Hypermethylation in Oncogenesis, J.T. DeAngelis, J.B. Berletch, L.G. Andrews, and T.O. Tollefsbol
Imprinting Alterations in Tumorigenesis, J. Bernier-Latmani and P. Shaw
Proteins that Modulate DNA Methylation Aberrations in Cancer, S. L. Walthall, S.M.O. Phipps, L.G. Andrews, and T. O. Tollefsbol
The Role of DNA Methylation in Cancer Progression, S.-W. Choi and S. Friso
Section 2: Histone Modifications in Cancer
Alterations in Histone Acetylation in Tumorigenesis, S.N. Saldanha and T.O. Tollefsbol
Histone Methylation and the Initiation of Cancer, S. Huang
The Role of Sirtuins in Aging and Tumorigenesis, X. Zhang, T. I. Hseih, S. V. Nicosia, and W. Bai
Proteins that Alter Histone Modifications in Cancer, A. Ao and J. Lu
Dietary and Environmental Influences on Histone Modifications in Cancer, S.N. Saldanha, V. Nandakumar, A. Elgavish, and T. O. Tollefsbol
Section 3: Other Epigenetic Aspects of Cancer
Noncoding RNAs in Cancer, M. Szymanski and J. Barciszewski
Cancer-linked DNA Hyper- and Hypomethylation: Chromosome Positional Effects, M. Ehrlich
Chromatin Remodeling and Cancer, S. Pennings and R.R. Meehan
Poly-ADP-ribosylation in Cancer, R.N. Sharan
Polycomb Group Proteins in Tumorigenesis, H.E.C. Niessen and J.W. Voncken
Cancer and Aging: The Epigenetic Connection, C.A. Cooney
Section 4: Epigenetics in the Diagnosis, Prognosis and Therapy of Cancer
DNA Methylation in Tumor Diagnosis, K. Ramachandran, E. Gordian and R. Singal
DNA Methylation Profiles as Prognostic Markers for Cancer, S. Thiagalingam and P. Papageorgis
Diagnosing Cancer Using Histone Modification Analysis, M. Verma and D. Kumar
Histone Modifications in Cancer Biology and Prognosis, M.A. McBrian, D. B. Seligson, and S. K. Kurdistani
Histone Deacetylase Inhibitors in Cancer Therapy, A.M. Sargeant, S.K. Kulp, Y.-S. Lu, A.-L. Cheng, and C.-S. Chen
Methylation Changes in Neoplasia: Diagnostic and Therapeutic Implications, E. Hatzimichael, J. Stebbing, and T. Crook
Clinical Trials and Approved Drugs for Epigenetic Cancer Therapy, D.M.E.I. Hellebrekers and M. van Engeland
Section 5: Future Directions
Future Directions in Epigenetic Cancer Research , J. Peedicayil

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