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Cancer Prevention: From the Laboratory to the Clinic: Implications of Genetic, Molecular, and Preventive Research

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Papers from a September 1994 conference explore recent advances in cancer prevention, highlighting the areas of genetics, molecular biology, screening, and preventive trials and emphasizing the prevention of breast, colon, and prostate cancer. Contains sections on targeting the susceptible population; controversies in early detection; experimental approaches to prevention; new frontiers in molecular biology; and preventive trials to reduce mortality. Poster papers discuss subjects including computer models for calculating cancer risk; cancer screening for low-income minority women; and chemoprevention. Of interest to physicians and researchers. No index. Annotation c. Book News, Inc., Portland, OR (
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Product Details

Table of Contents

Who Is Susceptible to Cancers of the Breast, Colon, and Prostate? 1
Family History of Cancer 12
The Contributions of Molecular Biology to Cancer Epidemiology 30
Psychosocial and Ethical Implications of Defining Genetic Risk for Cancers 41
Mammographic Screening in Women 40 to 49 Years Old 53
Can Mortality from Colorectal Cancer Be Reduced? 60
Changes in Early Detection of Prostate Cancer in the United States 68
What Are the Critical Attributes for Cancer Chemopreventive Agents? 73
How Can Carcinogenesis Be Inhibited? 82
The Role of Estrogen in Mammary Carcinogenesis 91
Molecular Genetics of Colorectal Cancer 101
The Spectrum of Mutations at the p53 Locus: Evidence for Tissue-specific Mutagenesis, Selection of Mutant Alleles, and a "Gain of Function" Phenotype 111
Preventive Clinical Trials: An Overview 129
An Overview of Considerations for the Testing of Tamoxifen as a Preventive for Breast Cancer 141
Retinoids in Cancer Chemoprevention: Clinical Trials with the Synthetic Analogue Fenretinide 148
The Potential Application of Finasteride for Chemoprevention of Prostate Cancer 163
Strategies for Colon Cancer Prevention 170
Indole-3-carbinol: A Novel Approach to Breast Cancer Prevention 180
Chemoprevention of Colon Cancer by Dietary Curcumin 201
Molecular Markers in Chemoprevention of Colon Cancer: Inhibition of Expression of ras-p21 and p53 by Sulindac during Azoxymethane-induced Colon Carcinogenesis 205
Inhibition of DNA Adduct Formation of 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) by Dietary Indole-3-carbinol (I3C) in the Mammary Gland, Colon, and Liver of the Female F-344 Rat 210
Chemoprevention of Mammary Preneoplasia: In Vitro Effects of a Green Tea Polyphenol 215
Effect of Retinoic Acid (RA) in MNU-induced Rat Mammary Tumors 223
Inhibition of Steroid 5[alpha]-Reductase Activity by Aliphatic Fatty Acids: Candidates for Chemoprevention of Prostate Cancer 227
Phenolic Antioxidants Induce UDP-glucuronosyltransferase in Rat Liver 231
Omeprazole Coinduces Multiple Xenobiotic-metabolizing Enzymes in the Rat 237
Activity of Maitake D-fraction to Inhibit Carcinogenesis and Metastasis 243
Inhibitory Effects of Chlorophyllin on Chemically Induced Mutagenesis and Carcinogenesis 246
The Association of Polymorphic N-Acetyltransferase (NAT2) with Breast Cancer Risk
Ovarian Cancer: A Model System to Study Cancer Genetics 253
Investigation of the Possible Role of WNT Genes in Human Breast Cancer 257
Developing a Role for Genetics within a Cancer Program 258
K-ras2 Mutation Spectrum, DNA Aneuploidy, and Epithelial Cell Proliferation in Colorectal Adenomas 261
Development of Murine (OC-147) and Human (H-106) Monoclonal Antibodies Reactive with a 53-kDa Ovarian Tumor-associated Antigen 264
A Case-Series Study of p53 Nuclear Overexpression in Early-Stage Stomach Cancer 269
Epidermal Growth Factor Receptor Status Correlates with Cell Proliferation-related 18A2/mtsl Gene Expression in Human Carcinoma Cell Lines 272
Low-Income, Minority Women: Barriers to Cancer Screening 277
Breast Cancer in African-American Families: Risk Perception, Cancer Worry, and Screening Practices of First-Degree Relatives 281
Head and Neck Screening Day for the Community 286
Involving Family Physicians in Education Programs for Cervical Cancer Screening 289
Adherence to Colorectal Cancer Screening: A Brief Overview 292
Planning The Next Step: A Screening Promotion and Nutrition Intervention Trial in the Work Site 296
Behavioral and Social Factors That Predict Participation in the Breast Cancer Prevention Trial 300
A Clinician-friendly Computer Program for Calculating Breast Cancer Risk Using the Gail and Claus Models 301
Object Class Networks (OCNs) for Interface-independent Calculation with Gail and Claus Models 308
Estrogen Metabolite Ratios and Risk Assessment of Hormone-related Cancers: Assay Validation and Prediction of Cervical Cancer Risk 312
The Strang National High Risk Registry: A Program for Delivery of Cancer Risk Information and a Resource for Research 317
Community Physician Willingness to Refer Cancer Patients for Treatment Education 323
Early Life Affects the Risk of Developing Breast Cancer 327
Changes in Serum Bile Acids in Normal Human Subjects following the Adoption of a Low-Fat Diet 331
Modulation of Tumor Necrosis Factor-[alpha] (TNF-[alpha]) Toxicity by the Pineal Hormone Melatonin (MLT) in Metastatic Solid Tumor Patients 334
Prospective Study on the Diagnosis and Prognosis of Lung Cancer by Using New Simultaneously Observed Seromarkers 337
Index of Contributors 341
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