Cancer Stem Cells

Hardcover (Print)
Buy New
Buy New from BN.com
$120.00
Used and New from Other Sellers
Used and New from Other Sellers
from $5.00
Usually ships in 1-2 business days
(Save 95%)
Other sellers (Hardcover)
  • All (16) from $5.00   
  • New (8) from $5.00   
  • Used (8) from $17.75   

Overview

A remarkable paradigm shift has occurred in recent years regarding the biological origins of cancer. The cancer stem cell hypothesis has challenged the foundational notions of cancer, and the therapeutic implications have been profound. Compelling evidence indicates that errors in the development of a small subset of adult stem cells can lead to cancer. Only this small sub-population of cells has the inherent ability to form tumors and metastasize. This book discusses the emerging field of cancer stem cell research, with contributions from leading experts on the basic biology, genetic pathways, and potentials for therapeutic targeting of cancer stem cells. It also covers clinical challenges for these new discoveries, namely, that cancer stem cells might be resistant to conventional chemotherapeutic and radiological treatments and may be at the biological core of relapse and therapeutic resistance. This book is an essential concise guide to the latest discoveries and therapies in cancer research.

Read More Show Less

Editorial Reviews

Doody's Review Service
Reviewer: Luigi Strizzi, MD, PhD (Children's Memorial Research Center)
Description: This is a succinct analysis of the concept of cancer stem cells (CSCs) in the context of basic and clinical science. The book describes important areas of cancer stem cell research including such topics as isolation and purification of CSCs, signaling pathways involved during self renewal, and pluripotency of these cells, as well as molecular approaches that may be employed to potentially target these pathways.
Purpose: The purpose is to focus on the clinical and therapeutic implications of CSCs. By exploring the concepts derived from basic research and effectively projecting these into the realm of clinical science, the book illuminates the importance of targeting CSCs in order to improve the efficacy of present-day anticancer therapy.
Audience: The editor is an established authority in the field who has published numerous important observations in CSC research. His selection of the diverse areas of CSC research covered in the different chapters will satisfy not only the interests of basic and clinical scientists, but also help students understand the complexity involved in cancer therapy and appreciate how CSC research is shedding new light on alternative therapeutic strategies that may compliment present-day approaches.
Features: The book is well written and describes in a general fashion the concepts necessary for basic comprehension of the biology and clinical relevancy of CSCs research. Most of the color illustrations are clear and useful in summarizing the important aspects of CSC research discussed in the text. Some figures, however, have typos. For example, in figure 8-2 there is a typo for the symbol gamma-secretase. Also, it would have been intriguing to mention in the chapter on melanoma cancer stem cells some of the current issues associated with the debate on the actual scarcity of CSCs in melanoma. Finally, the chapter title, "Targeting the Notch Signaling Pathway in Cancer Stem Cells," seems to imply that the different approaches discussed have been tested on CSCs, but no specific examples of results describing the effects of targeting notch signaling pathways in CSCs are mentioned. This is important for understanding the potential for unwanted side effects in normal and somatic stem cells given the pleiotropic nature of notch signaling.
Assessment: "Although work is still needed to identify specific markers that can be employed to identify and/or target CSCs and much debate surrounds whether tumor growth is actually driven by a presumably small subgroup of cells that can be called CSCs, the book does address useful areas in CSC research. The authors are successful in describing in a comprehensive way many concepts such as characterization and isolation of CSCs, the role played by CSCs during tumorigenesis and propagation of cancer, how CSCs may be responsible for resistance to therapy and recurrence, and how future targeting of the molecular mechanisms responsible for these characteristics in CSCs may improve cancer therapy.
(Reviewer Note: The histological images on the cover of this book have been published previously as a color panel for chapter 8, figure 2 in Stem Cells and Cancer, Bagley and Teicher (Humana Press, 2009))"
Read More Show Less

Product Details

  • ISBN-13: 9780521896283
  • Publisher: Cambridge University Press
  • Publication date: 8/24/2009
  • Pages: 182
  • Product dimensions: 7.10 (w) x 10.10 (h) x 0.70 (d)

Meet the Author

William L. Farrar, PhD, is Head of the Cancer Stem Cell Section at the Laboratory of Cancer Prevention, National Cancer Institute, Frederick, Maryland.

Read More Show Less

Table of Contents

Preface William L. Farrar; 1. Purification and characterization of cancer stem cells Elaine M. Hurt and William L. Farrar; 2. Prostate cancer stem cells Collene R. Jeter and Dean G. Tang; 3. Melanoma cancer stem cells Alexander Roesch and Meenhard Herlyn; 4. Mammospheres and breast carcinoma Massimiliano Bonafe; 5. Preventative and therapeutic strategies for cancer stem cells Stewart Sell and Gennadi Glinsky; 6. Targeting AML stem cells Monica L. Guzman, Gerrit J. Schuurhuis, and Craig T. Jordan; 7. Plasticity of multi-potent tumor cells and ES cells Lynne-Marie Postovit, Naira V. Margaryan, Elisabeth A. Seftor, Luigi Strizzi, Richard E. B. Seftor, and Mary J. C. Hendrix; 8. Hedgehog and GLI signaling in cancer Fritz Aberger; 9. Targeting notch signaling pathway in cancer stem cells Joon T. Park, Ie-Ming Shih, and Tian-Li Wang; 10. WNT-Beta catenin signaling in cancer Stephen Byers, Michael Pishvaian, Lopa Mishra, and Robert Glazer.

Read More Show Less

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star

(0)

4 Star

(0)

3 Star

(0)

2 Star

(0)

1 Star

(0)

Your Rating:

Your Name: Create a Pen Name or

Barnes & Noble.com Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & Noble.com that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & Noble.com does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at BN.com or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation

Reminder:

  • - By submitting a review, you grant to Barnes & Noble.com and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Noble.com Terms of Use.
  • - Barnes & Noble.com reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & Noble.com also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on BN.com. It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

 
Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)