Cannabis and Cannabinoids: Pharmacology, Toxicology, and Therapeutic Potential

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Study the latest research findings by international experts! This comprehensive volume presents state-of-the-art scientific research on the therapeutic uses of cannabis and its derivatives. All too often, discussions of the potential medical uses of this substance are distorted by political considerations that have no place in a medical debate. Cannabis and Cannabinoids: Pharmacology, Toxicology, and Therapeutic Potential features fair, equitable discussion of this emerging and controversial medical topic by the world's foremost researchers. Cannabis and Cannabinoids examines the benefits, drawbacks, and side effects of medical marijuana as a treatment for various conditions and diseases. This book discusses the scientific basis for marijuana's use in cases of pain, nausea, anorexia, and cachexia. It also explores its possible benefits in glaucoma, ischemia, spastic disorders, and migraine. Cannabis and Cannabinoids examines all facets of the medical use of marijuana, including: botany history biochemistry pharmacology clinical use toxicology side effects Cannabis and Cannabinoids is a reference work that will become indispensable to physicians, psychologists, researchers, biochemists, graduate students, and interested members of the public. No other book available offers this comprehensive, even-handed look at a deeply divisive subject.

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Editorial Reviews

From The Critics
Researchers from Europe, the US, Australia, and Brazil—most members of the International Cannabinoid Research Society—focus on the health aspects of the controversial plant, mentioning social and political dimensions only when required within the medicinal discussion. They consider botany, taxonomy, chemistry, and history; pharmacology and pharmacokinetics; indications for cannabis and THC; risks and side effects; other cannabinoids; and other constituents of cannabis. Annotation c. Book News, Inc., Portland, OR (
Doody's Review Service
Reviewer: Edward J. Otten, MD (University of Cincinnati College of Medicine)
Description: The authors have collected an enormous amount of material on cannabis and its potential for use in the clinical setting. The history, botany, pharmacology, toxicology, and therapeutic uses of cannabis and related natural and synthetic cannabinoids are discussed in depth. The internationally respected contributors bring a wealth of experience in clinical applications and research in this area to the book.
Purpose: The editors wish to clarify the body of knowledge on cannabis and its potential for medical therapy which, considering the controversy surrounding this subject in both the medical community and lay press, is a worthy goal. Unfortunately, despite the efforts of the contributors, there does not appear to be the scientific evidence necessary to support this goal.
Audience: This work is intended to be a resource for clinicians and researchers carrying out both animal studies and clinical trials. The contributors are recognized authorities in the areas of cannabinoid research, pharmacology and toxicology.
Features: The book's 38 chapters are grouped into six parts and arranged logically from botany and history to pharmacology, clinical indications, and risks. Although the history and pharmacology are quite interesting, the meat of the book is the discussion of the therapeutic effects and side effects of cannabinoids. Many of the authors stress the potential uses of cannabinoids based on animal studies and what the direction of future human and animal research should be. The black-and-white illustrations and tables are average for a book of this type and some would benefit from color enhancement.
Assessment: I was disappointed with the book as a whole. I expected some strong evidence for the use of cannabinoids in clinical medicine, but most of the conclusions were "there is not enough evidence," or "the side effects outweigh the benefits," or "the drug was not better than other standard treatments." Although this book is the best compilation of the available material on cannabis, it doesn't appear that enough scientific data exists to support many of the claims of its medical use.

2 Stars from Doody
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Product Details

  • ISBN-13: 9780789015082
  • Publisher: Taylor & Francis
  • Publication date: 8/28/2002
  • Pages: 478
  • Product dimensions: 6.00 (w) x 8.30 (h) x 1.30 (d)

Table of Contents

About the Editors
Definitions and Explanations
Pt. I Botany, Taxonomy, Chemistry, and History
Ch. 1 Botany of Natural Cannabis Medicines 3
Ch. 2 Taxonomy of Cannabinoids 15
Ch. 3 Chemical Constituents of Cannabis 27
Ch. 4 History of Cannabis in Western Medicine 37
Pt. II Pharmacology and Pharmacokinetics
Ch. 5 Effects of Cannabis and the Cannabinoids 55
Ch. 6 Pharmacokinetics 67
Ch. 7 Sites and Mechanisms of Action 73
Ch. 8 Mechanisms of Cannabinoid Analgesia 89
Ch. 9 Cannabinoids As Neuroprotectants Against Ischemia 101
Ch. 10 Possible Mechanisms in Autoimmune Diseases 111
Pt. III Indications for Cannabis and THC
Ch. 11 Review of Therapeutic Effects 123
Ch. 12 Medical Use of Cannabis: Experience in California 143
Ch. 13 Anorexia and Cachexia 153
Ch. 14 Antiemetic Effects of Cannabinoids 165
Ch. 15 Pain Therapy 181
Ch. 16 Migraine 187
Ch. 17 Spastic Disorders 195
Ch. 18 Movement Disorders 205
Ch. 19 Glaucoma and Cannabinoids 215
Ch. 20 Dependency and Cannabis 225
Pt. IV Risks and Side Effects
Ch. 21 Review of Unwanted Actions of Cannabis and THC 233
Ch. 22 Acute Effects of Cannabis and the Cannabinoids 249
Ch. 23 Cannabis and Dependence 257
Ch. 24 Pregnancy 269
Ch. 25 Immune System 279
Ch. 26 Hormonal System and Reproduction 289
Ch. 27 Long-Term Effects of Cannabis on Psyche and Cognition 299
Ch. 28 Cannabis and Alcohol in Motor Vehicle Accidents 313
Ch. 29 Respiratory Risks from Marijuana Smoking 325
Ch. 30 Contaminants and Adulterants in Herbal Cannabis 337
Ch. 31 Practical Hints 345
Pt. V Other Cannabinoids
Ch. 32 Overview of Cannabinoids Under Investigation 357
Ch. 33 Cannabidiol: Possible Therapeutic Application 359
Ch. 34 Anandamides: Potential Glaucoma Medicine? 371
Ch. 35 Therapeutic Potential of Ajulemic Acid (CT3) 381
Ch. 36 HU-211: A Cannabinoid Neuroprotective Agent 389
Pt. VI Other Constituents of Cannabis
Ch. 37 Noncannabinoid Components 401
Ch. 38 Hemp Seed and Hemp Oil 411
Resources 427
Index 429
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