Caracterizacion del Promotor del Gen Ehpgp1, de Entamoeba Histolytica

Overview

En este trabajo se estudio la participación de la región-234 y -196 pb del promotor del gen EhPgp1. El análisis estructural de esta región del promotor mostró la presencia de tres secuencias repetidas de 7 pb [R7(1), R7(2) y R7(3)] y dos secuencias repetidas de 9 pb [R9(1) y R9(2)], las cuales son secuencias consenso para diferentes factores de transcripción. Eliminando y mutando algunas de estas secuencias repetidas se vió que R9(2) es determinante para la actividad del promotor, ya que su eliminación produjo ...
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Overview

En este trabajo se estudio la participación de la región-234 y -196 pb del promotor del gen EhPgp1. El análisis estructural de esta región del promotor mostró la presencia de tres secuencias repetidas de 7 pb [R7(1), R7(2) y R7(3)] y dos secuencias repetidas de 9 pb [R9(1) y R9(2)], las cuales son secuencias consenso para diferentes factores de transcripción. Eliminando y mutando algunas de estas secuencias repetidas se vió que R9(2) es determinante para la actividad del promotor, ya que su eliminación produjo una reducción del 70 % en su actividad. La purificación parcial de las proteínas que se unen exclusivamente a R9(2), resultó en un complejo de entre 29 a 31 kDa y una banda de 63.6 kDa. La interacción de R9(2) con las proteínas parcialmente purificadas, produjo un complejo DNA-proteína específico, lo que nos sugiere que al menos una de las proteínas purificadas interactúa directamente con el DNA. Los resultados nos permiten ver que el control transcripcional del gen EhPgp1, está orquestado por diferentes secuencias entre las cuales se encuentran C/EBPI, C/EBPIII (Marchat y col., 2002) y R9(2), y por los factores de transcripción C/EBP-like y otros aun no identificados.
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Product Details

  • ISBN-13: 9783848466047
  • Publisher: AV Akademikerverlag GmbH & Co. KG.
  • Publication date: 7/10/2012
  • Language: Spanish
  • Pages: 128
  • Product dimensions: 6.00 (w) x 9.00 (h) x 0.30 (d)

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