The Carcinogenic Effects of Polycyclic Aromatic Hydrocarbons

The Carcinogenic Effects of Polycyclic Aromatic Hydrocarbons

by Andreas Luch
     
 

This book provides an overview on the molecular mode of action of carcinogenic polycyclic aromatic hydrocarbons (PAHs). PAHs are by-products arising from incomplete combustion of organic matter that are frequently released into our environment, and thus are ubiquitously detectable. Many PAHs are strong carcinogens in rodent bioassays and have been linked to increased… See more details below

Overview

This book provides an overview on the molecular mode of action of carcinogenic polycyclic aromatic hydrocarbons (PAHs). PAHs are by-products arising from incomplete combustion of organic matter that are frequently released into our environment, and thus are ubiquitously detectable. Many PAHs are strong carcinogens in rodent bioassays and have been linked to increased incidences of various types of cancer in humans. The present book covers all aspects of PAH-induced carcinogenesis; it is a collection of articles written by some of the most recognizable PAH researchers, reviewing the present knowledge in this field.

Product Details

ISBN-13:
9781860944178
Publisher:
Imperial College Press
Publication date:
06/30/2005
Pages:
516
Product dimensions:
6.10(w) x 9.00(h) x 1.10(d)

Table of Contents

In memoriam : Anthony Dipple (1940-1999)
1Polycyclic aromatic hydrocarbon-induced carcinogenesis - an introduction1
2Metabolic activation and detoxification of polycyclic aromatic hydrocarbons19
3Biomonitoring of polycyclic aromatic hydrocarbons - human exposure97
4Macromolecular adducts as biomarkers of human exposure to polycyclic aromatic hydrocarbons137
5DNA damage and mutagenesis induced by polycyclic aromatic hydrocarbons171
6Mechanisms of repair of polycyclic aromatic hydrocarbon-induced DNA damage211
7Aberrant gene expression and cell signalling/epigenetic effects induced by polycyclic aromatic hydrocarbons259
8Indicator assays for polycyclic aromatic hydrocarbon-induced genotoxicity283
9Tumorigenicity of polycyclic aromatic hydrocarbons315
10Genetic susceptibility to polycyclic aromatic hydrocarbon-induced carcinogenesis353
11Polycyclic aromatic hydrocarbon-induced carcinogenesis - an integrated view379

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