The Carcinogenic Effects of Polycyclic Aromatic Hydrocarbons

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This book provides an overview on the molecular mode of action of carcinogenic polycyclic aromatic hydrocarbons (PAHs). PAHs are by-products arising from incomplete combustion of organic matter that are frequently released into our environment, and thus are ubiquitously detectable. Many PAHs are strong carcinogens in rodent bioassays and have been linked to increased incidences of various types of cancer in humans. The present book covers all aspects of PAH-induced carcinogenesis; it is a collection of articles written by some of the most recognizable PAH researchers, reviewing the present knowledge in this field.
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Product Details

  • ISBN-13: 9781860944178
  • Publisher: Imperial College Press
  • Publication date: 6/30/2005
  • Pages: 516
  • Product dimensions: 6.10 (w) x 9.00 (h) x 1.10 (d)

Table of Contents

In memoriam : Anthony Dipple (1940-1999)
1 Polycyclic aromatic hydrocarbon-induced carcinogenesis - an introduction 1
2 Metabolic activation and detoxification of polycyclic aromatic hydrocarbons 19
3 Biomonitoring of polycyclic aromatic hydrocarbons - human exposure 97
4 Macromolecular adducts as biomarkers of human exposure to polycyclic aromatic hydrocarbons 137
5 DNA damage and mutagenesis induced by polycyclic aromatic hydrocarbons 171
6 Mechanisms of repair of polycyclic aromatic hydrocarbon-induced DNA damage 211
7 Aberrant gene expression and cell signalling/epigenetic effects induced by polycyclic aromatic hydrocarbons 259
8 Indicator assays for polycyclic aromatic hydrocarbon-induced genotoxicity 283
9 Tumorigenicity of polycyclic aromatic hydrocarbons 315
10 Genetic susceptibility to polycyclic aromatic hydrocarbon-induced carcinogenesis 353
11 Polycyclic aromatic hydrocarbon-induced carcinogenesis - an integrated view 379
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