Cardiac Allograft Rejection / Edition 1

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Heart transplantation remains one of the major scientific achievements of twentieth century medicine. During the past four decades, it has evolved from an unproven experimental surgical technique to the most effective form of therapy for refractory end-stage heart disease. It has captured the public's imagination and expanded our understanding of fundamental immunologic mechanisms that are responsible for cellular and humorally-mediated immunity. Despite its successes, many clinical and scientific problems remain. One or more bouts of acute cellular or humoral (vascular) rejection will occur in over 75% of transplant recipients despite current immunosuppressive strategies. Further, rejection directly results in approximately 20% of post-transplant deaths and is believed to play a major role in the development of late allograft dysfunction and coronary vasculopathy.
This book by international experts in the fields of transplantation medicine, immunobiology and cardiac imaging provides the reader with an up-to-date, consise summary of the latest developments in the diagnosis and treatment of acute cardiac rejection. It is axiomatic that a more complete understanding of the pathogenic processes involved in rejection will ultimately lead to its prevention. This volume will be useful to transplant cardiologists, cardiovascular surgeons, cardiac pathologists and transplant scientists who seek to prolong the lifespan and improve the quality of life of their transplant recipients.
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Editorial Reviews

Doody's Review Service
Reviewer: Joseph G Rogers, M.D.(Washington University School of Medicine)
Description: This is a comprehensive review of the basic and clinical aspects of acute and chronic cardiac allograft rejection.
Purpose: The purpose is to define the immunologic principles that underlie the immune response to transplanted tissue and then translate these into the field of clinical transplantation. The editors have selected relevant topics as well as authors who have capably highlighted the state-of-the-art in cardiac rejection.
Audience: The book is best suited for individuals with either a basic or clinical interest in cardiac transplantation or the general principles responsible for rejection of transplanted solid organs.
Features: Chapters that comprehensively describe the basic functions of the immune system and the role of its various components in the development of the response to allografted tissue begin the book. Other interesting sections include the role of humoral immunity in the development of acute and chronic rejection, xenotransplantation, and the induction of tolerance to allografted tissue. The clinical aspects of human cardiac allograft rejection are covered in detail including discussions of current strategies for the detection and treatment of acute cellular and vascular rejection. A chapter from Randy Morris's laboratory focuses on the next generation of immunosuppressive agents. The final section reviews noninvasive strategies to diagnose rejection using electrocardiography, echocardiography, and nuclear scanning. There is a section of color images, many of which significantly enhance the written descriptions of observed histological changes. A few of the images, however, add little to the overall quality of the book. Readers who are less familiar with this field may have some difficulty with the early chapters that refer to varying severities of rejection without providing a reference scheme for its grading. Further, a detailed discussion of the diagnosis and management of chronic rejection is omitted.
Assessment: This is an excellent resource and review of the current knowledge base pertaining to cardiac allograft rejection. It is well written and well referenced and it should be included in the personal and academic libraries of individuals and institutions involved in cardiac transplantation.

4 Stars! from Doody
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Product Details

  • ISBN-13: 9780792373292
  • Publisher: Springer US
  • Publication date: 9/30/2001
  • Edition description: 2001
  • Edition number: 1
  • Pages: 434
  • Product dimensions: 67.50 (w) x 97.50 (h) x 1.00 (d)

Table of Contents

List of Contributors
Ch. 1 Histocompatibility Antigens and Transplant Rejection 3
Ch. 2 Immunology of Cellular and Humoral Rejection after Cardiac Transplantation 21
Ch. 3 Immunobiology of Chronic Cardiac Allograft Rejection 49
Ch. 4 Inflammatory Cell Infiltration, Cytokines and Mechanisms of Myocyte Necrosis in Cardiac Transplant Rejection 65
Ch. 5 Apoptosis in Cardiac Transplant Rejection 89
Ch. 6 Pathology of Cardiac Allograft Vascular (Microvascular) Rejection: Impact on Patient Outcomes 101
Ch. 7 Strategies for the Induction of Allograft Tolerance 127
Ch. 8 Xenotransplantation: Hyperacute and Delayed Xenograft Rejection 153
Ch. 9 Endomyocardial Biopsy Diagnosis of Cardiac Allograft Rejection 177
Ch. 10 Clinical Diagnosis and Management of Cardiac Allograft Rejection and Maintenance Immunosuppression 197
Ch. 11 New Immunosuppressive Agents 233
Ch. 12 Treatment of Acute Vascular Rejection in Cardiac Allografts 267
Ch. 13 Evolution of Noninvasive Testing for the Detection of Cardiac Allograft Rejection 287
Ch. 14 Echocardiographic Diagnosis of Acute Allograft Rejection 299
Ch. 15 The Use of Magnetic Resonance Imaging in Cardiac Transplantation Rejection 321
Ch. 16 Targets for Radionuclide Imaging of Cardiac Allograft Rejection 341
Ch. 17 Detection of Apoptosis for the Noninvasive Diagnosis of Cardiac Allograft Rejection 349
Ch. 18 Detection of Cardiac Allograft Rejection by Noninvasive Imaging of Lymphocyte Infiltration 359
Ch. 19 Detection of Cardiac Allograft Rejection by Targeting Expression of Accessory Molecules on Cardiac Myocytes 367
Ch. 20 Algorithms for Management of Heart Transplant Rejection Based on Surveillance of Myocardial Damage by Antimyosin Antibody Imaging 381
Color Plates 399
Subject Index 423
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