Cardiac Allograft Rejection / Edition 1

Cardiac Allograft Rejection / Edition 1

by G. William Dec
     
 

Heart transplantation remains one of the major scientific achievements of twentieth century medicine. During the past four decades, it has evolved from an unproven experimental surgical technique to the most effective form of therapy for refractory end-stage heart disease. It has captured the public's imagination and expanded our understanding of fundamental… See more details below

Overview

Heart transplantation remains one of the major scientific achievements of twentieth century medicine. During the past four decades, it has evolved from an unproven experimental surgical technique to the most effective form of therapy for refractory end-stage heart disease. It has captured the public's imagination and expanded our understanding of fundamental immunologic mechanisms that are responsible for cellular and humorally-mediated immunity. Despite its successes, many clinical and scientific problems remain. One or more bouts of acute cellular or humoral (vascular) rejection will occur in over 75% of transplant recipients despite current immunosuppressive strategies. Further, rejection directly results in approximately 20% of post-transplant deaths and is believed to play a major role in the development of late allograft dysfunction and coronary vasculopathy.
This book by international experts in the fields of transplantation medicine, immunobiology and cardiac imaging provides the reader with an up-to-date, consise summary of the latest developments in the diagnosis and treatment of acute cardiac rejection. It is axiomatic that a more complete understanding of the pathogenic processes involved in rejection will ultimately lead to its prevention. This volume will be useful to transplant cardiologists, cardiovascular surgeons, cardiac pathologists and transplant scientists who seek to prolong the lifespan and improve the quality of life of their transplant recipients.

Read More

Product Details

ISBN-13:
9780792373292
Publisher:
Springer US
Publication date:
09/30/2001
Edition description:
2001
Pages:
434
Product dimensions:
67.50(w) x 97.50(h) x 1.00(d)

Related Subjects

Table of Contents

List of Contributors
Preface
Ch. 1Histocompatibility Antigens and Transplant Rejection3
Ch. 2Immunology of Cellular and Humoral Rejection after Cardiac Transplantation21
Ch. 3Immunobiology of Chronic Cardiac Allograft Rejection49
Ch. 4Inflammatory Cell Infiltration, Cytokines and Mechanisms of Myocyte Necrosis in Cardiac Transplant Rejection65
Ch. 5Apoptosis in Cardiac Transplant Rejection89
Ch. 6Pathology of Cardiac Allograft Vascular (Microvascular) Rejection: Impact on Patient Outcomes101
Ch. 7Strategies for the Induction of Allograft Tolerance127
Ch. 8Xenotransplantation: Hyperacute and Delayed Xenograft Rejection153
Ch. 9Endomyocardial Biopsy Diagnosis of Cardiac Allograft Rejection177
Ch. 10Clinical Diagnosis and Management of Cardiac Allograft Rejection and Maintenance Immunosuppression197
Ch. 11New Immunosuppressive Agents233
Ch. 12Treatment of Acute Vascular Rejection in Cardiac Allografts267
Ch. 13Evolution of Noninvasive Testing for the Detection of Cardiac Allograft Rejection287
Ch. 14Echocardiographic Diagnosis of Acute Allograft Rejection299
Ch. 15The Use of Magnetic Resonance Imaging in Cardiac Transplantation Rejection321
Ch. 16Targets for Radionuclide Imaging of Cardiac Allograft Rejection341
Ch. 17Detection of Apoptosis for the Noninvasive Diagnosis of Cardiac Allograft Rejection349
Ch. 18Detection of Cardiac Allograft Rejection by Noninvasive Imaging of Lymphocyte Infiltration359
Ch. 19Detection of Cardiac Allograft Rejection by Targeting Expression of Accessory Molecules on Cardiac Myocytes367
Ch. 20Algorithms for Management of Heart Transplant Rejection Based on Surveillance of Myocardial Damage by Antimyosin Antibody Imaging381
Color Plates399
Subject Index423

Read More

Customer Reviews

Average Review:

Write a Review

and post it to your social network

     

Most Helpful Customer Reviews

See all customer reviews >