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Cardiac Drug Therapy / Edition 7

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This book addresses the pharmacology and therapeutic application of drugs used to treat heart diseases and hypertension. Additions and updates to the sixth edition include six new chapters on current controversies in cardiac drug therapy such as the beta blocker issue many cardiologists are presently grappling with. The book provides practical advice on how to manage cardiac diseases and addresses the choice of one particular cardiac agent vs. another.

The book contains predominantly black-and-white illustrations, with some two-color illustrations.

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Editorial Reviews

From the Publisher

From the reviews of the seventh edition:

"...summarizing the rapidly evolving pharmacologic options available for the treatment of cardiovascular disease." -Doody's Book Review, Weighted Numerical Score:92 - 4 Stars

"...a valuable clinical reference" -Doody's Book Review, Weighted Numerical Score:92 - 4 Stars

"This publication focuses on cardiac pharmacotherapy. The intended audience for this text includes cardiologists, internists, and medical residents. The author’s intent is to help physicians understand the pharmacotherapy of various diseases and the differences within cardiovascular drug classes that impact drug selection. … The references … are reasonably updated and predominantly use tertiary sources. … has many useful observations and more drug information than most physician-written books. … This is an interesting book that provides decent clinical and clinical trial observations … ." (C Michael White, The Annals of Pharmacotherapy, Vol. 41, 2007)

Doody's Review Service
Reviewer: Stan N Thornton, MD (Ochsner Clinic Foundation)
Description: This synopsis of current pharmacologic options available to the practitioner in the treatment of cardiovascular disease updates the previous edition of 2003.
Purpose: The purpose is to provide clinicians with the most current, evidence-based information available on pharmacotherapy for a broad spectrum of cardiovascular diseases.
Audience: This book is of great utility for primary care providers and cardiovascular specialists alike, in both the inpatient and outpatient settings. Sections on emergency cardiac care also make this a valuable reference for providers in emergency departments and critical care areas.
Features: The 22 chapters address pharmacologic treatment of specific clinical entities such as hypertension, congestive heart failure, and acute coronary syndromes. The final chapter is an overview of landmark clinical trials which serve as the basis for current treatment guidelines. This book benefits from strategically placed tables and diagrams that summarize key points, and complete references for all recommendations. Drugs are indexed by both generic and trade names and common pitfalls of therapy, including drug interactions, are presented.
Assessment: The author has achieved his goal of summarizing the rapidly evolving pharmacologic options available for the treatment of cardiovascular disease. This is a timely revision of this book, which has already established itself as a valuable clinical reference.
Marie A. Wadas
The fourth edition of this book begins with chapters reviewing the dosage, mechanism of action, clinical indications, adverse effects, and interactions of commonly used cardiac drugs. The latter chapters review recent literature and give advice in the management of hypertension, angina pectoris, acute myocardial infarction, heart failure, cardiac arrhythmias, endocarditis, and hyperlipidemias. The purpose is to provide physicians with information that will allow them to choose the best drug for a given clinical situation. These are worthy objectives, and the author met his objectives. This book is suitable for medical students, medical residents, family physicians, internists, cardiologists, nurses, and all other practitioners involved with the care of cardiac patients. The author is a credible authority in the subject matter of the book. This book contains an adequate number of charts and algorithms. The references are up-to-date and pertinent. The unique features of this book make it user-friendly. The appendix provides charts listing doses of drugs frequently used in coronary care units. The inside front cover lists cardiac arrest drugs and their recommended doses. The inside back cover provides algorithms for the management of AV nodal reentrant tachycardia and sustained ventricular tachycardia. The text uses bold print throughout the chapters for quick retrieval of vital information and a second color for the chapter titles and drug names. This book is highly recommended as an up-to-date guide for the management of cardiac problems with various cardiac drugs. This revised edition has expanded the chapters on the management of hypertension, angina, acute myocardialinfarction, heart failure, arrhythmias, hyperlipidemia, and thrombolytics. It also contains a new chapter on drug interactions with other cardiac drugs and noncardiac drugs.
New edition of a handbook on modern therapeutics in patients with every type of cardiovascular disease. Khan (cardiologist, The Ottowa Hospital, and professor of medicine, U. of Ottawa) has updated drug information to include beta blockers, angiotensin 11 receptor blockers and ACE inhibitors, anti-platelet agents and statins, management of hypertension, a review of the controversy surrounding digoxin, and an analysis of calcium antagonists. Also included are drug tables indicating how a drug is supplied and its dosage, followed by advice as to efficacy, comparison with other drugs, indications, adverse side effects and interactions. Contains a global table of generic drugs available worldwide. Annotation c. Book News, Inc., Portland, OR (

4 Stars from Doody
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Product Details

  • ISBN-13: 9781588299048
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 5/28/2007
  • Series: Contemporary Cardiology Series
  • Edition description: 7th ed. 2007
  • Edition number: 7
  • Pages: 420
  • Product dimensions: 7.20 (w) x 10.10 (h) x 0.90 (d)

Table of Contents


1 Beta-Blockers: The Cornerstone of Cardiac
Drug Therapy

Please LIST HEADINGS for all chapters

2. Beta blocker Controversies
3 Angiotensin-converting Enzyme Inhibitors and
Angiotensin II Receptor Blockers 53
Mechanism of Action, 55
ACE Inhibitors Versus Other Vasodilators, 57
Clinical Indications, 59
Contraindications, 64
Advice, Adverse Effects, Interactions, 65
Individual ACE Inhibitors, 67
Angiotensin II Receptor Blockers, 75

4. ACE Inhibitors Controversies

5 Calcium Antagonists (Calcium Channel
Blockers) 81
Mechanism of Action, 81
Major Calcium Antagonists, 83
When to Choose a Calcium Antagonist, 93
Indications for Calcium Antagonists in the New Millennium, 94
Which Calcium Antagonist to Choose, 96
Combination of Calcium Antagonists with Beta-Blockers,
Nitrates, or Digoxin, 98

6. Calcium Antagonists Controversies

7 Diuretics 103
Indications, 105
Thiazides, 106
Loop Diuretics, 106
Potassium-Sparing Diuretics, 112
Other Diuretics, 117

Potassium Chloride Supplements, 118
Important New Information from Clinical Trials, 123

8 Hypertension new headings to be up dated 127
Relevant Key Issues, 127
Definitions, 130
Nondrug Therapy, 133
Laboratory Work-Up, 134
Which Drugs to Choose, 134
Beta-Blockers, 148
Diuretics, 150
ACE Inhibitors and Angiotensin II Receptor Blockers, 155
Calcium Antagonists (Extended Release), 160
Centrally Acting Drugs, 163
Alpha1-Blockers, 164
Hypertensive Crisis, 166

9 . Hypertension Controversies

10 Management of Angina 179
Salient Clinical Features, 179
Treatment of Stable Angina, 180
Management of Unstable Angina, 194
Variant Angina (Prinzmetal's), 201
Recommendations, 203
11 Management of Acute Myocardial
Infarction 209
New Terminology, 209
Therapeutic Implications, 209
Coronary Care Therapeutics, 216
Limitation of Infarct Size and Increased Survival, 221
Thrombolytic Therapy, 222
Beta-Blockers, 233
Nitrates, 235
Ace Inhibitors, 236
Statins, 237
Magnesium, 237
Management of Complications of Infarction, 238
Management of Non-ST-Elevation Myocardial Infarction, 248

12 Management of Heart Failure

new headings to add 255
The Size of the Problem, 255
Diagnosis, 258
Basic Cause, 261
Factors Precipitating Heart Failure, 262
Pathophysiology, 263
Vasodilators, 265
Diuretics, 270
Beta-Blockers, 272

Inotropic Agents, 275
Drug Treatment of Systolic Heart Failure, 287 Management of Diastolic Heart Failure, 293 Management of Pulmonary Edema, 294

13. Heart Failure Controversies

14 Management of Cardiac Arrhythmias delete page numbers 301
Classification, 302
Diagnosis of Arrhythmias, 306
Management of Supraventricular Arrhythmias, 309
Ventricular Arrhythmias, 322
Ventricular Tachycardia, 324
Antiarrhythmic Agents, 328
Class IA, 328
Class IB, 333
Class IC, 337
Class II, 340
Class III, 342
15 Cardiac Arrest

new headings 353
16 Management of Infective Endocarditis 375

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