Cardiac Electrophysiology: From Cell to Bedside: Expert Consult - Online and Print / Edition 5

Cardiac Electrophysiology: From Cell to Bedside: Expert Consult - Online and Print / Edition 5

by Douglas P. Zipes

ISBN-10: 1416059733

ISBN-13: 9781416059738

Pub. Date: 05/20/2009

Publisher: Elsevier Health Sciences

Completely revised to reflect developments in the field, the fourth edition of this comprehensive text continues to present a dual focus on the basic science of cardiac electrophysiology and its clinical applications. New chapters have been added on mechanisms of atrial fibrillation; the molecular and structural bases of HCN, stretch-activated, and inward rectifier…  See more details below


Completely revised to reflect developments in the field, the fourth edition of this comprehensive text continues to present a dual focus on the basic science of cardiac electrophysiology and its clinical applications. New chapters have been added on mechanisms of atrial fibrillation; the molecular and structural bases of HCN, stretch-activated, and inward rectifier channels; contraction-excitation feedback; nerve sprouting and arrhythmias; mechanisms of ventricular fibrillation; transgenic and knockout models of cardiac arrhythmias; Brugada syndrome; and catecholaminergic and short-coupled ventricular tachycardia. Each chapter begins with an outline and concludes with a list of references. Zipes is with the Indiana U. School of Medicine; Jalife, the SUNY Upstate Medical U. in Syracuse. There are over 200 contributors, most of them in the US, but many in Europe, and some in Asia. Annotation © 2004 Book News, Inc., Portland, OR

Product Details

Elsevier Health Sciences
Publication date:
Edition description:
New Edition
Product dimensions:
8.60(w) x 11.10(h) x 1.60(d)

Table of Contents

Color plates
Ch. 1Sodium channels1
Ch. 2Cardiac calcium channels10
Ch. 3Voltage-regulated potassium channels19
Ch. 4Intracellular signaling and regulation of cardiac ion channels33
Ch. 5Membrane pumps and exchangers42
Ch. 6Sarcoplasmic reticulum ion channels51
Ch. 7HCN channels : from genes to function59
Ch. 8Molecular organization and regulation of the cardiac gap junction channel Connexin4366
Ch. 9Biophysics of normal and abnormal cardiac sodium channel function77
Ch. 10Gating of cardiac delayed rectifier K[superscript +] channels88
Ch. 11Heart mechanoelectric transduction96
Ch. 12Pacemaker channels and normal automaticity103
Ch. 13Biophysical properties of inward rectifier potassium channels112
Ch. 14Homomeric and heteromeric gap junctions120
Ch. 15Pharmacology of the cardiac sodium channel127
Ch. 16Pharmacology of the L-type and T-type channels in the heart133
Ch. 17KCNQ1/KCNE1 macromolecular signaling complex : channel microdomains and human disease143
Ch. 18Drug-induced channelopathies151
Ch. 19Prospects for pharmacologic targeting of gap junction channels158
Ch. 20Heterogeneous expression of potassium channels in the mammalian myocardium169
Ch. 21Gap junction distribution and regulation in the heart181
Ch. 22Cellular mechanisms of sinoatrial activity192
Ch. 23Mechanisms of AV nodal excitability and propagation203
Ch. 24Intercellular communication and impulse propagation213
Ch. 25Cardiac tissue architecture determines velocity and safety of propagation222
Ch. 26Restitution, repolarization, and alternans as arrhythmogenic substrates232
Ch. 27Mechanoelectric transduction/feedback : prevalence and pathophysiology242
Ch. 28Ionic mechanisms of cardiac electrical activity : a theoretical approach255
Ch. 29Two-dimensional propagation in cardiac muscle267
Ch. 30Three-dimensional propagation in mathematical models : integrative model of the mouse heart273
Ch. 31Modeling cardiac defibrillation282
Ch. 32Molecular and cellular bases of [beta]-adrenergic and [alpha]-adrenergic modulation of cardiac rhythm291
Ch. 33Nerve sprouting and cardiac arrhythmias299
Ch. 34Cholinergic atrial fibrillation306
Ch. 35Theory of reentry317
Ch. 36Nonlinear dynamics of excitation and propagation in cardiac muscle327
Ch. 37Rotors and spiral waves in two dimensions336
Ch. 38Scroll waves in three dimensions345
Ch. 39Electrophysiology of the pulmonary veins : mechanisms of initiation of atrial fibrillation355
Ch. 40Mechanisms of maintenance of atrial fibrillation363
Ch. 41Electrical remodeling and chronic atrial fibrillation375
Ch. 42Mechanisms of initiation of ventricular tachyarrhythmias380
Ch. 43Dynamics and molecular mechanisms of ventricular fibrillation in normal hearts390
Ch. 44Mechanisms of ischemic ventricular fibrillation : who's the killer?399
Ch. 45Cellular mechanisms of defibrillation407
Ch. 46Global mechanisms of defibrillation417
Ch. 47Defibrillation waveforms426
Ch. 48Mouse models of cardiac arrhythmias433
Ch. 49Human molecular genetics and the heart444
Ch. 50Genetics of long QT, Brugada, and other channelopathies462
Ch. 51Pharmacogenomics of cardiac arrhythmias and impact on drug therapy471
Ch. 52Sinus rhythm abnormalities479
Ch. 53Atrioventricular block and atrioventricular dissociation485
Ch. 54Atrial flutter : mechanisms, clinical features, and management490
Ch. 55Atrial tachycardia500
Ch. 56Atrial fibrillation512
Ch. 57Junctional rhythms and junctional tachycardia523
Ch. 58Atrioventricular reentry and variants528
Ch. 59Electrophysiologic characteristics of atrioventricular nodal reentrant tachycardia : implications for the reentrant circuits
Ch. 60Atrial arrhythmias in congenital heart disease558
Ch. 61Ventricular tachycardia in patients with coronary artery disease569
Ch. 62Ventricular tachycardia in patients with dilated cardiomyopathy575
Ch. 63Ventricular tachycardia in arrhythmogenic right ventricular cardiomyopathies588
Ch. 64Ventricular arrhythmias in hypertrophic cardiomyopathy601
Ch. 65Ventricular tachycardia in patients with hypertrophy and heart failure608
Ch. 66Ventricular tachycardia in patients following surgery for congenital heart disease618
Ch. 67The Brugada syndrome625
Ch. 68Catecholaminergic polymorphic ventricular tachycardia and short-coupled torsades de pointes633
Ch. 69Arrythmias in patients with neurologic disorders640
Ch. 70Long QT syndrome - genotype-phenotype considerations651
Ch. 71Long QT syndrome : therapeutic considerations660
Ch. 72Ventricular tachycardia in patients with structurally normal hearts668
Ch. 73Bundle branch reentry683
Ch. 74Torsade de pointes687
Ch. 75Accelerated idioventricular rhythm and bidirectional ventricular tachycardia700
Ch. 76Ventricular fibrillation705
Ch. 77Prolonged repolarization and sudden infant death syndrome711
Ch. 78Sudden cardiac death720
Ch. 79Electrocardiographic manifestations of supernormal conduction, concealed conduction, and exit block733
Ch. 80Parasystole739
Ch. 81Differential diagnosis of wide QRS complex tachycardia747
Ch. 82Assessment of the patient with a cardiac arrhythmia759
Ch. 83Exercise-induced cardiac arrhythmias765
Ch. 84Use of long-term (holter) electrocardiographic recordings772
Ch. 85The use of implantable loop recorders793
Ch. 86High-resolution electrocardiography793
Ch. 87Body surface potential mapping803
Ch. 88Head-up tilt table testing812
Ch. 89Heart rate variability and baroreflex sensitivity823
Ch. 90Monophasic action potential recording831
Ch. 91T-wave alternans839
Ch. 92Neurocardiac imaging848
Ch. 93Mapping858
Ch. 94Wolff-Parkinson-White syndrome869
Ch. 95Sinus node dysfunction879
Ch. 96Syncope884
Ch. 97Results of clinical trials on atrial fibrillation895
Ch. 98Results of clinical trails of automatic external defibrillators and implantable cardioverter-defibrillators in patients at risk for sudden death901
Ch. 99Class I antiarrhythmic drugs : quinidine, procainamide, disopyramide, lidocaine, mexiletine, flecainide and propafenone911
Ch. 100[beta]-blockers and calcium channel blockers as antiarrhythmic drugs918
Ch. 101Class III antiarrhythmic drugs : amiodarone, ibutilide, and sotalol932
Ch. 102Adenosine and digoxin942
Ch. 103Impact of nontraditional antiarrhythmic drugs on sudden cardiac death950
Ch. 104New antiarrhythmic drugs959
Ch. 105Transthoracic cardioversion and defibrillation966
Ch. 106Implantable cardioverter-defibrillator : technical aspects970
Ch. 107Implantable cardioverter-defibrillators : clinical aspects980
Ch. 108Implantable atrial defibrillators for atrial fibrillation995
Ch. 109Implantable pacemakers1000
Ch. 110Newer applications of pacemakers1011
Ch. 111The biophysics and pathophysiology of lesion formation during radiofrequency catheter ablation1018
Ch. 112Catheter ablation of atrial fibrillation : triggers and substrate1028
Ch. 113Pulmonary vein isolation for atrial fibrillation1039
Ch. 114Catheter ablation of atrial flutter1053
Ch. 115Catheter ablation of atrial tachycardia1060

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