Cardiac Electrophysiology: From Cell to Bedside: Expert Consult - Online and Print / Edition 5

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2014 BMA Medical Book Awards Highly Commended in Cardiology category!

Cardiac Electrophysiology: From Cell to Bedside puts the latest knowledge in this subspecialty at your fingertips, giving you a well-rounded, expert grasp of every cardiac electrophysiology issue that affects your patient management. Drs. Zipes, Jalife, and a host of other world leaders in cardiac electrophysiology use a comprehensive, multidisciplinary approach to guide you through all of the most recent cardiac drugs, techniques, and technologies.

Get well-rounded, expert views of every cardiac electrophysiology issue that affects your patient management from preeminent authorities in cardiology, physiology, pharmacology, pediatrics, biophysics, pathology, cardiothoracic surgery, and biomedical engineering from around the world.
Visually grasp and easily absorb complex concepts through an attractive full-color design featuring color photos, tables, flow charts, ECGs, and more!

Integrate the latest scientific understanding of arrhythmias with the newest clinical applications, to select the right treatment and management options for each patient.
Stay current on the latest advancements and developments with sweeping updates and 52 NEW chapters - written by many new authors - on some of the hottest cardiology topics, such as new technologies for the study of the molecular structure of ion channels, molecular genetics, and the development of new imaging, mapping and ablation techniques.
Get expert advice from Dr. Douglas P. Zipes - a leading authority in electrophysiology and editor of Braunwald’s Heart Disease and the Heart Rhythm Journal - and Dr. Jose Jalife - a world-renowned leader and researcher in basic and translational cardiac electrophysiology.
Access the full text online at Expert Consult, including supplemental text, figures, tables, and video clips.

Your purchase entitles you to access the web site until the next edition is published, or until the current edition is no longer offered for sale by Elsevier, whichever occurs first. If the next edition is published less than one year after your purchase, you will be entitled to online access for one year from your date of purchase. Elsevier reserves the right to offer a suitable replacement product (such as a downloadable or CD-ROM-based electronic version) should online access to the web site be discontinued.

The book contains predominantly black-and-white illustrations, with some color illustrations.

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Editorial Reviews

Brian Olshansky
This second edition, edited by two internationally recognized experts and written by many contributors, purports to be a comprehensive, definitive text covering all of cardiac electrophysiology. A smaller first edition was published five years ago. The authors hope to provide a complete and authoritative book on cardiac electrophysiology. They include basic and clinical aspects of electrophysiology in this 14-section, 138-chapter book. The objectives are worthy and the book is needed. Generally, the authors meet their stated objectives. The authors do not indicate the intended audience. A small audience of cardiac electrophysiology fellows and clinical and basic electrophysiologists (MDs and PhDs) will benefit. General cardiologists, surgeons, internists, and medical residents are not the target audience. The editors and 173 contributors are credible authorities, among the best known in their field. The contributors generously illustrate this book with black-and-white graphs, tables, figures, and charts. Most are of excellent quality, but some are too small. The color illustrations will benefit only a few. Most chapters contain pertinent references (in large numbers) but most references are over two to three years old. The table of contents is adequate. Some subjects are included in more than one section. Some chapters are narrow in scope with abstruse titles. The index is difficult to use. The book is large and heavy, but impressive and highly attractive. This book is one of the most comprehensive texts ever written in cardiac electrophysiology. The new information is enough to justify replacement of the previous edition. It is a monumental, multiauthored, book with numerous chapters.The content and presentation of most chapters are simply excellent, but the quality, format, and references vary. Although this will be a definitive text in cardiac electrophysiology, the editors underemphasize important (often, clinically based) subjects at the expense of more narrow topics. The large number of chapters (many of them short) makes the work disjointed and significant overlap exists. Some chapters are not complete and provide biased information. Despite these shortcomings, this edition is needed and welcomed. I highly recommended it for cardiac electrophysiologists, libraries, and bookstores.
Doody's Review Service
Reviewer: Saima Karim, D.O.(Ochsner Clinic Foundation)
Description: This book reviews the basic cellular biology, biophysics, physiology, and pharmacogenomics of electrophysiology before moving on to the clinical aspects such as mechanisms, clinical features, pharmacogenomics, pharmacology, electrical therapy, and surgical treatment of arrhythmias.
Purpose: The objective is to educate scientists and clinicians interested in electrophysiology in the basic science and the clinical mechanisms, features, and management of arrhythmias.
Audience: This book appeals to a broad audience of basic scientists and clinicians in various stages of training and practice.
Features: It begins with a meticulous description of the cellular, molecular, biophysical, and genetic basis of normal and pathological impulse generation and propagation. After these basic science concepts, the book introduces clinical aspects of larger electrophysiological concepts before delving into pathophysiology, diagnosis, and treatment of arrhythmias. This book uniquely merges basic science concepts with practical clinical pearls. The illustrations are very helpful in understanding the physiology, pathology, diagnosis, and treatment of arrhythmias.
Assessment: This book uniquely provides a comprehensive review of basic science concepts of electrophysiology that are later translated into practical clinical terms. This edition includes the latest information on evolving concepts in the field.
From the Publisher
"This book uniquely provides a comprehensive review of basic science concepts of electrophysiology that are later translated into practical clinical terms. This edition includes the latest information on evolving concepts in the field."-Saima Karim, DO(Ochsner Clinic Foundation) Doody Review: 4 stars

3 Stars from Doody
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Product Details

  • ISBN-13: 9781416059738
  • Publisher: Elsevier Health Sciences
  • Publication date: 5/20/2009
  • Edition description: New Edition
  • Edition number: 5
  • Pages: 1184
  • Product dimensions: 8.60 (w) x 11.10 (h) x 1.60 (d)

Table of Contents

Color plates
Ch. 1 Sodium channels 1
Ch. 2 Cardiac calcium channels 10
Ch. 3 Voltage-regulated potassium channels 19
Ch. 4 Intracellular signaling and regulation of cardiac ion channels 33
Ch. 5 Membrane pumps and exchangers 42
Ch. 6 Sarcoplasmic reticulum ion channels 51
Ch. 7 HCN channels : from genes to function 59
Ch. 8 Molecular organization and regulation of the cardiac gap junction channel Connexin43 66
Ch. 9 Biophysics of normal and abnormal cardiac sodium channel function 77
Ch. 10 Gating of cardiac delayed rectifier K[superscript +] channels 88
Ch. 11 Heart mechanoelectric transduction 96
Ch. 12 Pacemaker channels and normal automaticity 103
Ch. 13 Biophysical properties of inward rectifier potassium channels 112
Ch. 14 Homomeric and heteromeric gap junctions 120
Ch. 15 Pharmacology of the cardiac sodium channel 127
Ch. 16 Pharmacology of the L-type and T-type channels in the heart 133
Ch. 17 KCNQ1/KCNE1 macromolecular signaling complex : channel microdomains and human disease 143
Ch. 18 Drug-induced channelopathies 151
Ch. 19 Prospects for pharmacologic targeting of gap junction channels 158
Ch. 20 Heterogeneous expression of potassium channels in the mammalian myocardium 169
Ch. 21 Gap junction distribution and regulation in the heart 181
Ch. 22 Cellular mechanisms of sinoatrial activity 192
Ch. 23 Mechanisms of AV nodal excitability and propagation 203
Ch. 24 Intercellular communication and impulse propagation 213
Ch. 25 Cardiac tissue architecture determines velocity and safety of propagation 222
Ch. 26 Restitution, repolarization, and alternans as arrhythmogenic substrates 232
Ch. 27 Mechanoelectric transduction/feedback : prevalence and pathophysiology 242
Ch. 28 Ionic mechanisms of cardiac electrical activity : a theoretical approach 255
Ch. 29 Two-dimensional propagation in cardiac muscle 267
Ch. 30 Three-dimensional propagation in mathematical models : integrative model of the mouse heart 273
Ch. 31 Modeling cardiac defibrillation 282
Ch. 32 Molecular and cellular bases of [beta]-adrenergic and [alpha]-adrenergic modulation of cardiac rhythm 291
Ch. 33 Nerve sprouting and cardiac arrhythmias 299
Ch. 34 Cholinergic atrial fibrillation 306
Ch. 35 Theory of reentry 317
Ch. 36 Nonlinear dynamics of excitation and propagation in cardiac muscle 327
Ch. 37 Rotors and spiral waves in two dimensions 336
Ch. 38 Scroll waves in three dimensions 345
Ch. 39 Electrophysiology of the pulmonary veins : mechanisms of initiation of atrial fibrillation 355
Ch. 40 Mechanisms of maintenance of atrial fibrillation 363
Ch. 41 Electrical remodeling and chronic atrial fibrillation 375
Ch. 42 Mechanisms of initiation of ventricular tachyarrhythmias 380
Ch. 43 Dynamics and molecular mechanisms of ventricular fibrillation in normal hearts 390
Ch. 44 Mechanisms of ischemic ventricular fibrillation : who's the killer? 399
Ch. 45 Cellular mechanisms of defibrillation 407
Ch. 46 Global mechanisms of defibrillation 417
Ch. 47 Defibrillation waveforms 426
Ch. 48 Mouse models of cardiac arrhythmias 433
Ch. 49 Human molecular genetics and the heart 444
Ch. 50 Genetics of long QT, Brugada, and other channelopathies 462
Ch. 51 Pharmacogenomics of cardiac arrhythmias and impact on drug therapy 471
Ch. 52 Sinus rhythm abnormalities 479
Ch. 53 Atrioventricular block and atrioventricular dissociation 485
Ch. 54 Atrial flutter : mechanisms, clinical features, and management 490
Ch. 55 Atrial tachycardia 500
Ch. 56 Atrial fibrillation 512
Ch. 57 Junctional rhythms and junctional tachycardia 523
Ch. 58 Atrioventricular reentry and variants 528
Ch. 59 Electrophysiologic characteristics of atrioventricular nodal reentrant tachycardia : implications for the reentrant circuits
Ch. 60 Atrial arrhythmias in congenital heart disease 558
Ch. 61 Ventricular tachycardia in patients with coronary artery disease 569
Ch. 62 Ventricular tachycardia in patients with dilated cardiomyopathy 575
Ch. 63 Ventricular tachycardia in arrhythmogenic right ventricular cardiomyopathies 588
Ch. 64 Ventricular arrhythmias in hypertrophic cardiomyopathy 601
Ch. 65 Ventricular tachycardia in patients with hypertrophy and heart failure 608
Ch. 66 Ventricular tachycardia in patients following surgery for congenital heart disease 618
Ch. 67 The Brugada syndrome 625
Ch. 68 Catecholaminergic polymorphic ventricular tachycardia and short-coupled torsades de pointes 633
Ch. 69 Arrythmias in patients with neurologic disorders 640
Ch. 70 Long QT syndrome - genotype-phenotype considerations 651
Ch. 71 Long QT syndrome : therapeutic considerations 660
Ch. 72 Ventricular tachycardia in patients with structurally normal hearts 668
Ch. 73 Bundle branch reentry 683
Ch. 74 Torsade de pointes 687
Ch. 75 Accelerated idioventricular rhythm and bidirectional ventricular tachycardia 700
Ch. 76 Ventricular fibrillation 705
Ch. 77 Prolonged repolarization and sudden infant death syndrome 711
Ch. 78 Sudden cardiac death 720
Ch. 79 Electrocardiographic manifestations of supernormal conduction, concealed conduction, and exit block 733
Ch. 80 Parasystole 739
Ch. 81 Differential diagnosis of wide QRS complex tachycardia 747
Ch. 82 Assessment of the patient with a cardiac arrhythmia 759
Ch. 83 Exercise-induced cardiac arrhythmias 765
Ch. 84 Use of long-term (holter) electrocardiographic recordings 772
Ch. 85 The use of implantable loop recorders 793
Ch. 86 High-resolution electrocardiography 793
Ch. 87 Body surface potential mapping 803
Ch. 88 Head-up tilt table testing 812
Ch. 89 Heart rate variability and baroreflex sensitivity 823
Ch. 90 Monophasic action potential recording 831
Ch. 91 T-wave alternans 839
Ch. 92 Neurocardiac imaging 848
Ch. 93 Mapping 858
Ch. 94 Wolff-Parkinson-White syndrome 869
Ch. 95 Sinus node dysfunction 879
Ch. 96 Syncope 884
Ch. 97 Results of clinical trials on atrial fibrillation 895
Ch. 98 Results of clinical trails of automatic external defibrillators and implantable cardioverter-defibrillators in patients at risk for sudden death 901
Ch. 99 Class I antiarrhythmic drugs : quinidine, procainamide, disopyramide, lidocaine, mexiletine, flecainide and propafenone 911
Ch. 100 [beta]-blockers and calcium channel blockers as antiarrhythmic drugs 918
Ch. 101 Class III antiarrhythmic drugs : amiodarone, ibutilide, and sotalol 932
Ch. 102 Adenosine and digoxin 942
Ch. 103 Impact of nontraditional antiarrhythmic drugs on sudden cardiac death 950
Ch. 104 New antiarrhythmic drugs 959
Ch. 105 Transthoracic cardioversion and defibrillation 966
Ch. 106 Implantable cardioverter-defibrillator : technical aspects 970
Ch. 107 Implantable cardioverter-defibrillators : clinical aspects 980
Ch. 108 Implantable atrial defibrillators for atrial fibrillation 995
Ch. 109 Implantable pacemakers 1000
Ch. 110 Newer applications of pacemakers 1011
Ch. 111 The biophysics and pathophysiology of lesion formation during radiofrequency catheter ablation 1018
Ch. 112 Catheter ablation of atrial fibrillation : triggers and substrate 1028
Ch. 113 Pulmonary vein isolation for atrial fibrillation 1039
Ch. 114 Catheter ablation of atrial flutter 1053
Ch. 115 Catheter ablation of atrial tachycardia 1060
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